Lung Physiology
Ventilation |
• To lower PaCO2, one must either increase RR or increase tidal volume. • Minute ventilation = RR x VT**. |
Oxygenation |
• Monitored by O2 saturation and PaO2. • To increase PaO2 in the ventilated patient, one must either increase FiO2 or PEEP. • Can also extend inspiratory time fraction. • Can improve oxygen delivery by increasing CO or hemoglobin. • Can decrease oxygen requirements by decreasing work of breathing, agitation or fever. • Remove pulmonary vasodilators like nitroprusside. |
Key Terms
Minute Ventilation |
• RRxVT. Should be adjusted to achieve baseline PaCO2. • Initial VT of 8-10mL/kg is appropriate in most cases (lower in ARDS and COPD). • A rate of 10-12 breaths/min is appropriate. |
FiO2 |
• Initially should be 100%. • Quickly titrate down and use the lowest possible level to maintain a PaO2 of 50-60 or higher. • Avoid oxygen toxicity with FiO2<60% if possible. • If FiO2 of 0.5 does not result in adequate PaO2, add PEEP or CPAP (allow reduction in FiO2). |
Inspiratory/expiratory ratio |
• Duration of time allotted to inspiration compared to expiration in one delivered breath. Duarte of each breath is determined by set RR. Increased time in inspiration will proportionally decrease tie-in expiration. 1:2 is usually used. |
PEEP |
• Positive pressure maintained at the end of passive exhalation to keep alveoli open. • 2.5-10cm H2O is the initial setting. • Can be added to any mode of ventilation and used mostly in hypoxic respiratory failure. • Increases lung compliance and oxygenation (improves gas exchange). • Prevents alveolar collapse and atelectasis. • Can cause barotrauma or low CO (due to decreased venous return and increased PVR, esp. with hypovolemia). |
|
|
Mechanical Ventilation
Indications |
• Significant respiratory distress or respiratory arrest. • Impaired or reduced level of consciousness with inability to protect the airway (absent gag or cough reflex). • Metabolic acidosis without adequate compensation. • Respiratory muscle fatigue. • Significant hypoxemia (PaO2<70mmHg) or hypercapnia (PaCo2>50mmHg). • Respiratory acidosis (pH<7.2) with hypercapnia. |
Complications
Complications |
• Anxiety and discomfort treated with sedation. • Tracheal secretions need regular suction. • Nosocomial pneumonia (if >72 hours), accidental extubation, • Barotrauma (high P) • Oxygen toxicity (if FiO2>60% for >2 days). • Hypotension (high intrathoracic pressure decreases VR). • Tracheomalacia (softening of cartilage) due to prolonged ETT. Prevent with tracheostomy if >2weeks. • Laryngeal damage, GI effects (stress ulcers, cholestasis). |
Complications
Complications |
• Anxiety and discomfort treated with sedation. • Tracheal secretions need regular suction. • Nosocomial pneumonia (if >72 hours), accidental extubation, • Barotrauma (high P) • Oxygen toxicity (if FiO2>60% for >2 days). • Hypotension (high intrathoracic pressure decreases VR). • Tracheomalacia (softening of cartilage) due to prolonged ETT. Prevent with tracheostomy if >2weeks. • Laryngeal damage, GI effects (stress ulcers, cholestasis). |
|
|
Modes
Assisted Controlled Ventilation |
• Initial mode used in respiratory failure. • Guarantees a "backup" minute ventilation. • The ventilator delivers a breath of predetermined tidal volume when the patient initiates a breath. • If the patient does not initiate a breath, the ventilator takes control and delivers a breath at a predetermined rate. • All breaths are deviled by the ventilator. • The patient can go over the determined rate but not under, and every breath is a determined TV. |
Synchronous Intermittent Mandatory Ventilation |
• Patients can breath above the mandatory rate without help from the ventilator. • The tidal volume of extra breaths is not determined by the ventilator. • When the patient breathes spontaneously, there is no preset volume, but the patient has a guaranteed predetermined rate. • Delivers the mandatory breath in synchrony with patient's initiated spontaneous breath (so they do not overlap). • Good for support of ventilation and weaning. |
Continuous Positive Airway Pressure (CPAP) |
• Positive pressure (0-20cm H2O) is delivered continuously during expiration and inspiration, but no volume breaths are delivered. • The patient breaths on their own. • The only parameters to set are PEEP and pressure support. • If the patient is being weaned, CPAP can be used to assess whether they can be extubated. |
Pressure Support Ventilation |
• Mostly during weaning trials. • Pressure is delivered with an initiated breath to assist breathing. • Pressure is not continuous and only responds to initiated breaths. • It enhances respiratory efforts made by the patient. • PEEP may be added. |
|