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Bugs to Drugs Comprehensive Guide

Gram (+) Organisms

Cocci
Aerobic
(Cluster)
↣ Staph. aureus
↣ Staph. epider­midis
↣ Staph. saprop­hyticus
 
Aerobic
(Pair/­Chain)
↣ Strep. pneumoniae
↣ Strep. pyogenes (Grp A)
↣ Strep. agalactiae (Grp B)
↣ Viridans strept­ococci
↣ Entero­coccus faecium
↣ Entero­coccus faecalis
 
Anaerobic
↣ Peptoc­occus
↣ Peptos­tre­pto­coccus
Bacilli
Aerobic
↣ Coryne­bac­terium
↣ Listeria (facul­tative aerobic & anaerobic)
↣ Lactob­acillus
↣ Gardne­rella
↣ Bacillus
 
Anaerobic
↣ Clostr­idium
↣ Lactob­acillus
↣ Actino­myces
↣ Propio­nib­act­erium
Gram-p­ositive bacteria, identi­fiable by their thick cell walls staining purple, are targeted by antibi­otics like penici­llin, glycop­eptides (e.g., vancom­ycin), and lipope­ptides (e.g., daptom­ycin) that disrupt cell wall synthesis or membrane integrity, depending on the bacter­ium's resistance and infection site.

Pneumonia (PNA): Pathogens

Commun­ity­-ac­quired PNA (CAP)
(+) Strep. pneumoniae
(–) Haemop­hilus influenzae
(–) Moraxella catarr­halis
(A) Mycoplasma pneumoniae
(A) Legionella species
(A) Chlamydia pneumoniae
Hospit­al-­acq­uired PNA (HAP)
Ventil­ato­r-a­cquired PNA (VAP)
(+) MRSA
(–) Pseudo­monas aeruginosa
(–) Acinet­obacter species
(–) Entero­bac­ter­iaceae family
Aspiration
(–) Entero­bac­ter­iaceae family
(+/–) Anaerobic organisms
Pneumonia (PNA) is the infectious disease of the Lower Respir­atory Tract. The 3 main routes of inocul­ation are inhaled, bloods­tream, and aspira­tion.

Skin & Soft Tissue Infections (SSTI)

Cellulitis
Follic­ulitis
 
Furuncles, Carbun­cles, Abscesses
S. aureus is the most common cause
 
Diffuse cellulitis (Erysi­pelas)
Group A Strep (GAS; S. pyogenes) is the most common cause
 
Impetigo
Strep pyogenes -or- S. aureus are the most common cause
 
Necrot­izing SSTIs
Strept­ococcus pyogenes (GAS)
Mixed infection (Gram +/- and anaerobes
Clostr­idium species
Diabetic Foot Infections
Begin as skin ulcera­tion, can spread into deeper tissue and bone
S. aureus
Strep species
Entero­bac­ter­iaceae
Anaerobes
Surgical Site Infections
(Develop >48 hrs post-op)
Staph. aureus
Strep species
Immuno­com­pro­mised
HIV, hemato­log­y/o­ncology
Common or unusual bacteria
 

Gram (-) Organisms

Bacilli
Anaerobic
↣ Bacter­oides
↣ Prevotella
↣ Fusoba­cterium
 
Aerobic
(Ferme­nters)
Entero­bac­ter­iaceae:
↣ Proteus
↣ E. coli
↣ Klebsiella
↣ Entero­bacter
↣ Serratia
↣ Salmonella
↣ Shigella
↣ Citrob­acter
Other (Vibri­o/A­ero­monas)
 
Aerobic
(Non-f­erm­enters)
↣ Pseudo­monas
↣ Acinet­obacter
↣ Stenot­rop­homonas
↣ Burkho­lderia
 
Aerobic
(Fasti­dium)
↣ Haemop­hilus influenzae
↣ Helico­bacter pylori
↣ Campyl­obacter
↣ Bartonella
↣ HACEK group
Cocci
 
↣ Neisseria
↣ Moraxella
Gram-n­egative bacteria have thin cell walls with an outer membrane, staining red in the Gram stain process. They are treated with antibi­otics such as aminog­lyc­osides, cephal­osp­orins, and fluoro­qui­nol­ones, which target protein synthesis, cell wall synthesis, and DNA replic­ation, respec­tively, adapting to their unique outer membrane and resistance mechan­isms.

Urinary Tract Infect­ions: Pathogens

Uncomp­licated UTIs
(–) PEK (E. coli, Klebsiella pneumo­niae, Proteus)
(+) Entero­cocci
(+) Staph. saprop­hyticus
Compli­cated UTIs
The above pathogens + MDR pathogens in those with frequent UTIs and nosocomial UTIs (S. aureus, Pseudo­mona)
Urinary Tract Infections can be acquired via Ascending (urethral coloni­zation with fecal flora) or Descending (blood­stream → kidneys).
Uncomp­licated is defined as UTI in young, otherwise healthy females.
Compli­cated is defined as everyone else (e.g. Pyelon­eph­ritis, Prosta­titis, Cathet­er/­Nos­ocomial related UTIs, and Renal stones)
 

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