Antibody Cheat Sheet (DRAFT) by Carsonmccall

MOLECULES THAT BIND AG
MHC (on APCs)	binds peptides from protein Ag and presents to T-cells
TCR (on T-cells)	binds a specific Ag in context of MHC (processed Ag!)
BCR (on B-cells)	binds a specific Ag in **FREE solution (UNpro­cessed Ag!)
AB REGIONS
F(ab) region	determines Ag specif­icity
	binds Ag at its variable region
Fc region	determines Ab class
	binds to the host cells via its constant region
	determines the Ab class' biological activity

DETERM­INATION OF:
1.	Pathogen exposure
2.	Vaccine effect­iveness
3.	Level and kind of Ab response
4.	Sufficient passive transfer of Ab
DETECTION OF AB LEVEL/­CLASS IN:
>	serum
>	CSF
>	joint fluid