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Cheatography

Phosphodiesterase Inhibitors Cheat Sheet (DRAFT) by

Drugs for HF (Module 2 - Pharmacology)

This is a draft cheat sheet. It is a work in progress and is not finished yet.

PHOSPH­ODI­EST­ERASE INHIBITORS

Block enzyme phosph­odi­est­erase
Increase calcium for myocardial contra­ction
Cause positive inotropic response and vasodi­lation
Increase contra­ctility and decrease afterload
Short-term therapy only

PROTOTYPE DRUG

milrinone
(Primacor)
 

MECHANISM OF ACTION

To block enzyme phosph­odi­est­erase in cardiac & smooth muscle, increasing myocardial contra­ction force and cardiac output

PRIMARY USE

as a short-term therapy of advanced HF

ADVERSE EFFECTS

Hypoka­lemia
Hypote­nsion
Ventri­cular dysrhy­thmias
 

NURSE'S ROLE

ASSESS:
 
- potassium levels
 
- for renal impairment
 
- for dysrhy­thmias
Monitor for hypote­nsion
IV:
Monitor for ventri­cular dysrhy­thmias
 
PATIENT TEACHING:
 
Report irregular or rapid heart rate
 
Report fever of 101 F or higher
 
Report increase in chest pain
If given IV:
Report fever of 101 F or higher or pain/s­welling at infusion site.