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Autacoids Cheat Sheet (DRAFT) by

Autacoids, Purines, Histamine, Serotonin

This is a draft cheat sheet. It is a work in progress and is not finished yet.

Purines

 

Purines

Adenosine
ADP (Adenosine Diphos­phate)
ATP (Adenosine Tripho­sphate)
- Formed from the breakdown of ATP.
- Plays a critical role in platelet aggreg­ation.
- Acts via P2 receptors (P2X and P2Y)
- Acts via adenosine receptors (A1, A2A, A2B, A3)
- Released during tissue injury -> binds to P2Y12 receptors on platelets
- Mediates pain, inflam­mation and immune response
- Functions include: Vasodi­lation, Sedative effects in brain, Inhibition of neurot­ran­smitter release, Antinf­lmm­atory
- Promotes clot formation
- Can trigger cell death pathways or survival signalling