This is a draft cheat sheet. It is a work in progress and is not finished yet.
blood cell development
begins with pluripotent stem cells |
involves formation of blasts which morphologically have a high nucleocytoplasmic ratio, prominent nucleus, open chromatin configuration, basophilic cytoplasm |
blasts mature in a lineage specific manner in response to growth factors & the end result is effector cells |
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bone marrow architecture
E3-E4 = different stages of red cell development; Ly – lymphocyte; Mega – megakaryocyte; Promy – promyelocyte, my – myelocyte, meta – metamyelocyte, band -band form; SC – stromal cell, Seg – segmented neutrophil
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haemopoietic sites
development stage |
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site |
embryo |
0-2 months |
yolk, sac |
foetus |
2-7 months |
liver, spleen |
foetus |
5-9 months |
bone marrow |
infants |
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all bones - bone marrow |
adults |
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vertebrae, ribs, sternum, skull, sacrum, pelvis, proximal ends of femur |
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