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Disruption of TCA cycle may cause health issue
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phosphatase deficiency
pyruvate dehydrogenase is always phosphorylated and thus inactive. |
Consequently, glucose is processed to lactate rather than acetyl CoA. |
This condition results in unremitting lactic acidosis—high blood levels of lactic acid. |
. In such an acidic environment, many tissues malfunction, most notably the central nervous system. |
Nausea,Vomiting,Abdominal pain,Anxiety... |
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Summary
Pyruvate Dehydrogenase Links Glycolysis to the Citric Acid Cycle |
Oxidative decarboxylation, from pyruvate to acetyl CoA, Mt |
The Citric Acid Cycle Oxidizes Two-Carbon Units |
8 steps, 3 irreversible steps, 3 NADH, 1 FADH2, 1 ATP, 2 CO2 |
Entry to the Citric Acid Cycle and Metabolism Through It Are Controlled |
PDH, isocitrate dehydrogenase, alpha-Ketoglutarate dehydrogenase |
The Citric Acid Cycle Is a Source of Biosynthetic Precursors |
Citrate, alpha-ketoglutarate, succinyl CoA, oxaloacetate |
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