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Progesterone is used as a contraceptive, protection for clients on HRT, endometriosis, Dysfunctional uterine bleeding, and palliative treatment for advanced uterine cancer.
Drug Class: Progesterone
Prototype Med |
Medroxyprogesterone Acetate |
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Provera |
Other Meds |
norethindrone (Micronor) |
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Megestrol acetate (Megace) |
Action: Antagonize estrogen influenced tissue growth in the uterine endometrium, thus prevent hyperplasia or an overgrowth of the lining of the uterus
Therapeutic Use
Treatment of endometriosis |
Treatment of dysfunctional uterine bleeding |
Treatment of endometrial carcinoma |
Adverse Drug Reactions
Thromboembolism/Breast cancer |
Breakthrough bleeding and other menstrual irregularities |
Nausea/Edema |
Nursing Interventions
Monitor for and report any indications of deep vein thrombosis, pulmonary embolism, myocardial infarction, and cerebrovascular accident. |
Encourage clients who smoke to quit. |
Recommend mammograms and breast examinations at appropriate intervals. |
Discontinue the drug for any indications of breast cancer. |
Monitor the pattern and amount of any reported bleeding. |
Inform clients that this effect diminishes with time. |
Monitor weight. |
Administration
Give orally daily or cyclically or via IM injection. |
Expect amenorrhea and other menstrual irregularities. |
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Patient Education
Report leg or chest pain, leg edema, sudden change in vision, severe head- ache, or shortness of breath. |
Do not smoke. |
Stop taking at least 4 weeks before any surgery that increases the risk of thromboembolic events. |
Perform breast self-examination every month. |
Obtain a mammogram and breast examination at the recommended intervals. |
Report any unusual breakthrough bleeding or spotting or changes in menstru- al patterns. |
Take oral forms with food. Take at bedtime. |
Contrindications
Pregnancy - teratogenic effects |
History of or high risk for thromboembolic events |
Undiagnosed vaginal bleeding |
Liver disease |
Cervical, uterine, vaginal, or breast cancer |
Precautions
Asthma/Siezures/Migraines |
Cerebrovascular accident |
Cardiac or kidney dysfunction |
Interactions
Rifampin (Rifadin), ritonavir (Norvir), phenobarbital (Luminal), carbamazepine (Tegretol), primidone (Mysoline), phenytoin (Dilantin), and St. John’s wort can reduce the effectiveness of progesterones. |
Progesterones may require adjustments in the dosage of hypoglycemic drugs. |
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