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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
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% Document Info
\author{shivamm2007}
\pdfinfo{
  /Title (repro-endocrine-review.pdf)
  /Creator (Cheatography)
  /Author (shivamm2007)
  /Subject (Repro/Endocrine Review Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Repro/Endocrine Review Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{shivamm2007} via \textcolor{DarkBackground}{\uline{cheatography.com/182952/cs/38071/}}}
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\noindent
\begin{multicols}{3}
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  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}shivamm2007 \\
  \uline{cheatography.com/shivamm2007} \\
  \end{tabulary}
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  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 4th April, 2023.\\
   Page {\thepage} of \pageref{LastPage}.
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{p{0.58478 cm} x{1.08602 cm} x{1.00248 cm} x{1.50372 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{5.377cm}}{\bf\textcolor{white}{Cushings Disease}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Decreased} ACTH & Exogenous \seqsplit{glucocorticoids} &  &  \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Adrenal Tumor &  &  \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Increased} ACTH & High dose \seqsplit{dexamethasone} & \seqsplit{Increased} ACTH & Ectopic ACTH suppression \tn 
% Row Count 8 (+ 3)
% Row 3
\SetRowColor{white}
 & High dose \seqsplit{dexamethasone} & \seqsplit{Decreased} ACTH & Cushings \seqsplit{Disease(Pituitary} Adenoma) \tn 
% Row Count 11 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & CRH \seqsplit{Stimulation} & Increase \seqsplit{ACTH/Cortisol} & Cushings \seqsplit{Disease(Pituitary} Adenoma) \tn 
% Row Count 14 (+ 3)
% Row 5
\SetRowColor{white}
 & CRH \seqsplit{Stimulation} & No change \seqsplit{ACTH/Cortisol*} & Ectopic ACTH secretion. \tn 
% Row Count 17 (+ 3)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{4}{x{5.377cm}}{*Dexamethasone should suppress ACTH and cortisol- if it doesn't then ectopic cause} \tn 
% Row Count 19 (+ 2)
% Row 7
\SetRowColor{white}
\mymulticolumn{4}{x{5.377cm}}{**CRH should increase ACTH- if it doesn't then ACTH is being secreted from ectopic cause} \tn 
% Row Count 21 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Congenital Adrenal Hyperplasia}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Deficiency}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{17a-hydroxylase}}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 2 (+ 0)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{21-hydroxylase}}} \tn 
% Row Count 3 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 3 (+ 0)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{11B-hydroxylase}}} \tn 
% Row Count 4 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 4 (+ 0)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{3B-hydroxysteroid dehydrogenase}}} \tn 
% Row Count 5 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 5 (+ 0)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 5 (+ 0)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Heavy Menses}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Adenomyosis} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Endometriosis} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Leiomyoma (Fibroids)} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Endometrial Hyperplasia} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Endometrial Cancer} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.14471 cm} x{3.83229 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Male Genitalia}}  \tn
% Row 0
\SetRowColor{LightBackground}
DHT & External Male Genitalia+ Prostate \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{Testosterone} & Internal Male Genitalia(SEED= Seminal Vesicles, Epididymis, Ejaculatory Duct, Ductus Deferens) \tn 
% Row Count 6 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{*if female internal genitalia is present in a male then think {\bf{Anti Mullerian Hormone deficiency}}} \tn 
% Row Count 8 (+ 2)
% Row 3
\SetRowColor{white}
Estrogen & Breast development \tn 
% Row Count 9 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\seqsplit{Aromatase} & Converts testosterone-{}-\textgreater{} estrogen \tn 
% Row Count 11 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{0.96071 cm} x{1.21133 cm} x{1.21133 cm} p{0.79363 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{5.377cm}}{\bf\textcolor{white}{Vaginitis}}  \tn
% Row 0
\SetRowColor{LightBackground}
If there is vaginal \seqsplit{inflammation} & Think {\bf{Trichomoniasis}} or {\bf{Candida vaginitis}} &  &  \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
\seqsplit{Bacterial} \seqsplit{vaginosis} & fishy odor, clue \seqsplit{cells(squamous} epithelial cells), (+) whiff test & Due to antibiotic use & Treat with \seqsplit{metronidazole} \tn 
% Row Count 11 (+ 6)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Trichmoniasis} & frothy, \seqsplit{yellow-green} discharge, motile \seqsplit{trichomonads}, & Due to hx of STIs & Treat with \seqsplit{metronidazole} \tn 
% Row Count 16 (+ 5)
% Row 3
\SetRowColor{white}
Candida & cottage cheese, \seqsplit{pseudohyphae} & Due to OCP use, \seqsplit{antibiotics}, \seqsplit{immunosuppression}, diabetes & Treat with {\bf{fluconazole}} \tn 
% Row Count 22 (+ 6)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.24425 cm} x{3.73275 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Ovarian Tumor}}  \tn
% Row 0
\SetRowColor{LightBackground}
Struma Ovarii & Germ cell tumor \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Associated with thyrotoxicosis (since it can secrete thyroid hormone) \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & Gross: Oily cystic mass \tn 
% Row Count 6 (+ 1)
% Row 3
\SetRowColor{white}
 & Microscopic: thyroid follicles filled with colloid and surrounded by ovarian storm \tn 
% Row Count 9 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.34379 cm} x{3.63321 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Ducts}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Paramesonephric} & form internal female genitalia (fallopian tubes, uterus, upper vagina, cervix) \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\seqsplit{Mesonephric} & In females= degenerate to form Gartner duct \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & In males= epididymis, seminal vesicles, ductus deferens, ejaculatory ducts \tn 
% Row Count 8 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{3.18528 cm} x{1.79172 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Genital Ulcers}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Painful}} & {\bf{Painless}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Chancroid (H.Ducreyi) & Chlamydia \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
HSV & Syphilis \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.28942 cm} x{2.68758 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Staging/ Gleason Score}}  \tn
% Row 0
\SetRowColor{LightBackground}
High Gleason score & poorly differentiated \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Higher Staging & metastasis \tn 
% Row Count 2 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.83689 cm} x{2.14011 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Lymph Nodes}}  \tn
% Row 0
\SetRowColor{LightBackground}
Para-Aortic & Ovaries/ Testes \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Superficial Inguinal & Scrotum \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
Deep Inguinal & Glans Penis \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anorexia and Amenorrhea}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Due to hypothalamic suppression of GnRH} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.73735 cm} x{2.23965 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Hypertension in Pregnancy}}  \tn
% Row 0
\SetRowColor{LightBackground}
Think Pre-Eclampsia/ Eclampsia & New-onset HTN \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Proteinuria \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & End-organ dysfunction \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
 & (+ seizures in eclampsia) \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.94103 cm} x{3.03597 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Vaginal Bleeding during Pregnancy}}  \tn
% Row 0
\SetRowColor{LightBackground}
Placenta Accreta (Painful) & Due to absence of endometrial decide basalts \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Or previous uterine scarring (prior C-section) \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Molar Pregnancy (Painful)} \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
 & Partial Mole- has fetal tissue \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Complete Mole- NO fetal tissue \tn 
% Row Count 9 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Ectopic Pregnancy (Mild Pain)} \tn 
% Row Count 10 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Abruptio Placentae (Painful)} \tn 
% Row Count 11 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Placenta Previa (Painless bleeding)} \tn 
% Row Count 12 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Cervicitis (PID)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Neisseria Gonorrhoeae} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Chlamydia Trachomatis} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{*if antibiotic coverage remains incomplete then can lead to infertility} \tn 
% Row Count 4 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.94103 cm} x{3.03597 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Combination Therapy}}  \tn
% Row 0
\SetRowColor{LightBackground}
Buserelin and Bicalutamide & Buserelin- continuous stimulation of pituitary gland to down-regulate GnRH-{}-\textgreater{} decrease LH-{}-\textgreater{}decrease testosterone \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
 & Bicalutamide- helps prevent the initial testosterone surge effect from the buserelin administration \tn 
% Row Count 10 (+ 5)
% Row 2
\SetRowColor{LightBackground}
Leuprolide and Flutamide & Leuprolide-long acting GnRH antagonist- causes a transient increase in LH-{}-\textgreater{}testosterone levels \tn 
% Row Count 14 (+ 4)
% Row 3
\SetRowColor{white}
 & Flutamide-competitive testosterone receptor blocker-counteracts the initial surge of testosterone \tn 
% Row Count 19 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.14471 cm} x{3.83229 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Drugs for pregnancy termination}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Mifepristone} & -partial progesterone agonist-{}-\textgreater{}causes placental separation and uterine contraction \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\seqsplit{Misoprostol} & E1 agonist-{}-\textgreater{} stimulates uterine contractions \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Methotrexate} & Folic acid antagonist-{}-\textgreater{}destroys proliferating fetal cells \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.44333 cm} x{3.53367 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Mullein Agencies vs Androgen Insensitivity}}  \tn
% Row 0
\SetRowColor{LightBackground}
Mullein Genesis & Stage 4: breast; Stage 4: pubic hair \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
AIS & Stage 4: breast; Stage 2: pubic hair \tn 
% Row Count 4 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.79632 cm} x{4.18068 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Phases of Meiosis}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Female} & Prophase I until ovulation \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
 & Metaphase 2 until fertilization \tn 
% Row Count 2 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Postmenopausal bleeding}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Think Endometrial Hyperplasia or Cancer} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Testicular Torsion}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Has absent cremasteric reflex} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Physiologic Changes in Pregnancy}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Increase CO} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Increase Plasma Volume} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Decrease SVR} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Increase Response Tidal Volume} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Decrease FRC} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Increase GFR} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Chronic hypoventilation (-{}-\textgreater{}respiratory alkalosis)} \tn 
% Row Count 7 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Congenital Rubella}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{I heart ruby earrings:} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{I("eye")-{}-\textgreater{} cataracts} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Heart-{}-\textgreater{}PDA} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Ruby-{}-\textgreater{} Rubella (enveloped, single-stranded, positive-sense RNA virus)} \tn 
% Row Count 5 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Earrings-{}-\textgreater{} sensorineural hearing loss} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.33919 cm} x{2.63781 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Hypoglycemic Episodes}}  \tn
% Row 0
\SetRowColor{LightBackground}
More common with {\bf{Sulfonylureas}}: & Inhibits K+ channel to allow for Ca2+ influx \tn 
% Row Count 3 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{SGLT-2 Inhibitors (-glifozin)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{decrease renal absorption of glucose and sodium} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.64078 cm} x{1.3731 cm} x{2.56312 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Insulin (Endogenous vs Exogenous)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Endogenous} & insulin+{\bf{C-peptide}} & endopeptidases in secretory granules cleave proinsulin into insulin and C-peptide \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
 &  & Sulfonylureas and Meglitinides are the only ones that stimulate endogenous insulin production \tn 
% Row Count 9 (+ 5)
% Row 2
\SetRowColor{LightBackground}
 &  & Insulin producing tumors \tn 
% Row Count 11 (+ 2)
% Row 3
\SetRowColor{white}
\seqsplit{Exogenous} & insulin only &  \tn 
% Row Count 13 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.44333 cm} x{3.53367 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Congenital Hypothyroidism}}  \tn
% Row 0
\SetRowColor{LightBackground}
high TSH; low T4 & {\emph{Initially asymptomatic}} because of the presence of material thyroxine \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Need levothyroxine treatment otherwise can lead to neurocognitive dysfunction \tn 
% Row Count 6 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{SIADH}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Think Euvolemic Hyponatremia} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Neonatal Hypoglycemia}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Mother had gestational diabetes-{}-\textgreater{} hyperglycemia in mother-{}-\textgreater{}hyperglycemia in baby-\textgreater{} so baby was producing high levels of insulin to counteract high glucose-{}-\textgreater{} pancreatic B cell hyperplasia since it is working extra-{}-\textgreater{} once born then not receiving high levels of glucose from mother but still producing a lot of insulin=neonatal hypoglycemia} \tn 
% Row Count 7 (+ 7)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.64701 cm} x{4.32999 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{MEN Syndromes}}  \tn
% Row 0
\SetRowColor{LightBackground}
MEN 1 & Pituitary (Usually a Prolactinoma) \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
 & Pancreas (Usually Zollinger Ellison syndrome) \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & Parathyroid \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{} \tn 
% Row Count 4 (+ 0)
% Row 4
\SetRowColor{LightBackground}
Men 2A & Parathyroid \tn 
% Row Count 6 (+ 2)
% Row 5
\SetRowColor{white}
 & {\bf{Medullary}} thyroid carcinoma \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
 & Pheochromocytoma \tn 
% Row Count 8 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{} \tn 
% Row Count 8 (+ 0)
% Row 8
\SetRowColor{LightBackground}
MEN 2B & {\bf{Medullary}} thyroid carcinoma \tn 
% Row Count 10 (+ 2)
% Row 9
\SetRowColor{white}
 & Pheochromocytoma \tn 
% Row Count 11 (+ 1)
% Row 10
\SetRowColor{LightBackground}
 & {\bf{Oral Ganglioneuromas}} \tn 
% Row Count 12 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{SIADH}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Think Euvolemic Hyponatremia} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{TBG Deficiency}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{low total T4, normal free T4, normal TSH} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.51041 cm} x{1.64772 cm} x{1.41887 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Adrenal Gland Secretions}}  \tn
% Row 0
\SetRowColor{LightBackground}
Adrenal Cortex & Zona Glomerulosa & Aldosterone \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Zona Fasiculata & Cortisol \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & Zona Reticularis & Sex Hormones \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
Adrenal Medulla &  & \seqsplit{Catecholamines} \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Ketone Bodies}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Can't be utilize by RBCs since they lack mitochondria} \tn 
% Row Count 2 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Symptomatic Relief of Thyrotoxicosis}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{B-blockers} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.64701 cm} x{4.32999 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Diabetes}}  \tn
% Row 0
\SetRowColor{LightBackground}
Type 1 & Due to autoimmune response against beta cells-{}-\textgreater{} loss of insulin production \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & More susceptible to DKA \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & Younger patients \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
Type 2 & Due to insulin resistance \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Older patients \tn 
% Row Count 8 (+ 1)
% Row 5
\SetRowColor{white}
 & Pancreatic islet amyloid deposition \tn 
% Row Count 10 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.44333 cm} x{3.53367 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Antihyperlipidemic drugs}}  \tn
% Row 0
\SetRowColor{LightBackground}
Statins & Primarily lowers cholesterol \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Ezetimibe & Lowers cholesterol and LDL \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
Fibrates & Lowers triglycerides \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
Niacin & Lowers triglyceride and LDL, Increases HDL \tn 
% Row Count 5 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Bile acid resins & Lowers LDL \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.14471 cm} x{3.83229 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Glucose Transporters}}  \tn
% Row 0
\SetRowColor{LightBackground}
GLUT-4 & Insulin Dependent-{}-\textgreater{} expression increases with insulin concentration \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Muscle cells, Adipocytes \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
GLUT 1,2,3,5 & Insulin-Independent-{}-\textgreater{} does NOT increase with insulin concentration \tn 
% Row Count 7 (+ 3)
% Row 3
\SetRowColor{white}
 & Brain, Kidney, Intestine, RBCs, Liver \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Bone Formation/ Loss}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{PTH-{}-\textgreater{} osteoblast-{}-\textgreater{}Bone formation} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{PTH-{}-\textgreater{}RANK(osteoblasts)+RANK-L/NFkB-L (osteoclasts)-{}-\textgreater{}net bone loss} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{OPG-bind competitively to RANK-L to prevent bone loss} \tn 
% Row Count 5 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.9862 cm} x{1.9908 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Insulin Drugs}}  \tn
% Row 0
\SetRowColor{LightBackground}
Long-acting (Glargine, detemir, degludec) & mimic regular insulin \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Short-acting (Lispro, aspart, glulisine) & mimics postprandial insulin \tn 
% Row Count 4 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Permissive Effect of Cortisol on Ne/Epi}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Cortisol indirectly acts Ne/Epi receptors to upregulate them-{}-\textgreater{} this then makes them available for the the catecholamines to bind to them} \tn 
% Row Count 3 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Turner syndrome (45, XO)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Widely spaced nipples} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Ovarian dysgenesis (streak ovaries)} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Horseshoe kidney} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Short} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Webbed neck} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Coarctation of aorta} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Aortic Dissection} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Bicuspid Aortic valve} \tn 
% Row Count 8 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Cystic Hygroma in neck} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Klinefelter (47, XXY)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Decreased inhibin levels} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Learning disabilities} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Gynecomastia} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Small, firm testes} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Tall} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Edwards syndrome}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Hypertonia} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Clenched fists} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Rocker bottom feet} \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Down syndrome}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Upslanting palpebral fissures} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Epicanthal folds} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Single palmer crease} \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Drugs and common AE}}  \tn
% Row 0
\SetRowColor{LightBackground}
Levothyroxine & Atrial fibrillation \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
PTU, methimazole & Agranulocytosis (Nuetropenia) \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & PTU- Hepatotoxic (But preferred drug in last two trimesters) \tn 
% Row Count 6 (+ 3)
% Row 3
\SetRowColor{white}
 & \seqsplit{Methimazole-Teratogenic} in FIRST trimester \tn 
% Row Count 9 (+ 3)
% Row 4
\SetRowColor{LightBackground}
Sulfonyureas & Hypoglycemia \tn 
% Row Count 10 (+ 1)
% Row 5
\SetRowColor{white}
HIV HAART therapy & Lipodystrophy \tn 
% Row Count 11 (+ 1)
% Row 6
\SetRowColor{LightBackground}
B-Blockers & Mask Hypoglycemic episodes \tn 
% Row Count 13 (+ 2)
% Row 7
\SetRowColor{white}
Estrogen & ischemic stoke (therefore don't give in migraines since they already have an increased baseline for an ischemic stroke) \tn 
% Row Count 19 (+ 6)
% Row 8
\SetRowColor{LightBackground}
Metformin & Lactic acidosis (CI in renal insufficiency) \tn 
% Row Count 22 (+ 3)
% Row 9
\SetRowColor{white}
Tamoxifen & Gynecomastia \tn 
% Row Count 23 (+ 1)
% Row 10
\SetRowColor{LightBackground}
Glucocorticoids & Osteoporosis \tn 
% Row Count 24 (+ 1)
% Row 11
\SetRowColor{white}
GLP-1 agonists \seqsplit{(exenatide/liraglutide)} & Weight loss \tn 
% Row Count 26 (+ 2)
% Row 12
\SetRowColor{LightBackground}
Trazadone & Priapism \tn 
% Row Count 27 (+ 1)
% Row 13
\SetRowColor{white}
Bile acid resins (Cholestyramine, Cholestipol, Colesevelam) & Hypertriglceridemia \tn 
% Row Count 30 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.73735 cm} x{2.23965 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Intracellular Pathways}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Pathway}} & {\bf{Hormones}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Bind activated receptors to DNA to modify transcription & Steroid and thyroid hormones \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
Adenylyl cyclase converts ATP to cyclic amp-{}-\textgreater{} activates protein kinase A & PTH, ACTH, TSH, ADH(V2), glucagon \tn 
% Row Count 8 (+ 4)
% Row 3
\SetRowColor{white}
Bind G protein coupled receptor that activate PLC & GnRH, TRH, Ang II, AHDH(V1) \tn 
% Row Count 11 (+ 3)
% Row 4
\SetRowColor{LightBackground}
PLC activates PIP3-{}-\textgreater{} DAG+IP3 to then activate PKC & GnRH, TRH, Ang II, AHDH(V1) \tn 
% Row Count 14 (+ 3)
% Row 5
\SetRowColor{white}
JAK-STAT Pathway & GH \tn 
% Row Count 15 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.09034 cm} x{2.88666 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Familial Hyperlipoproteinemia (Type 1)}}  \tn
% Row 0
\SetRowColor{LightBackground}
deficiency of LPL or Apo C-2: & Hypertriglyceridemia \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & recurrent acute pancreatitis \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & milky appearing retinal vasculature (lipemia retinals) \tn 
% Row Count 7 (+ 3)
% Row 3
\SetRowColor{white}
 & yellow populates on extensor surfaces (eruptive xanthomas) \tn 
% Row Count 10 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.24425 cm} x{3.73275 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Keep-it-Simple Concepts}}  \tn
% Row 0
\SetRowColor{LightBackground}
PTH & increase Ca+ (Primary regulator of PTH-if low then PTH increases to increase Ca2+ levels) \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & decrease PO4- \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & increase Vitamin D (by upregulating 1-a-hydroxylase) \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Ca2+} \tn 
% Row Count 7 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\seqsplit{Calcitonin} & counteracts Ca2+ \tn 
% Row Count 8 (+ 1)
% Row 5
\SetRowColor{white}
Insulin & decreases glucose (bloodstream-{}-\textgreater{} adipose tissue/skeletal muscle) \tn 
% Row Count 11 (+ 3)
% Row 6
\SetRowColor{LightBackground}
 & counteracts glucagon \tn 
% Row Count 12 (+ 1)
% Row 7
\SetRowColor{white}
Glucagon & increases glucose (adipose tissue/skeletal muscle-{}-\textgreater{}bloodstream) \tn 
% Row Count 15 (+ 3)
% Row 8
\SetRowColor{LightBackground}
Vitamin D & increase Ca+ \tn 
% Row Count 16 (+ 1)
% Row 9
\SetRowColor{white}
 & increase PO4- \tn 
% Row Count 17 (+ 1)
% Row 10
\SetRowColor{LightBackground}
Leydig cells & LH-{}-\textgreater{}secrete testosterone \tn 
% Row Count 19 (+ 2)
% Row 11
\SetRowColor{white}
Sertoli cells & FSH-{}-\textgreater{}spermatogenesis and increase inhibin \tn 
% Row Count 21 (+ 2)
% Row 12
\SetRowColor{LightBackground}
 & increases glucose by glycogenolysis and gluconeogenesis in the {\emph{liver}} \tn 
% Row Count 24 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.4931 cm} x{3.4839 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Neimann-Pick vs Tay-Sachs}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Neimann-Pick} & \seqsplit{Hepatomegaly/Splenomegaly} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Tay-Sachs & NO \seqsplit{hepatomegaly/splenomegaly} \tn 
% Row Count 2 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}