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% Document Info
\author{schat}
\pdfinfo{
  /Title (npb-101-smooth-muscles.pdf)
  /Creator (Cheatography)
  /Author (schat)
  /Subject (NPB 101 Smooth Muscles Cheat Sheet)
}

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\begin{multicols}{3}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{NPB 101 Smooth Muscles Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{schat} via \textcolor{DarkBackground}{\uline{cheatography.com/213611/cs/46510/}}}
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\noindent
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}schat \\
  \uline{cheatography.com/schat} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 28th May, 2025.\\
   Page {\thepage} of \pageref{LastPage}.
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  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Smooth Muscle Features}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Location: Walls of hollow organs and tubes, structures that change in volume. (ex-intestines).} \tn 
% Row Count 2 (+ 2)
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\mymulticolumn{1}{x{5.377cm}}{Non-striated. \newline Uninuclear. \newline Spindle-shaped cells (dia = 2-10 μm, l = 50-400 μm). \newline Divide lifelong. \newline Thick filaments = myosin. \newline Thin filaments = actin, anchored to the plasma membrane or dense bodies. \newline Filaments are not organized into myofibrils, no sarcomeres. \newline No troponin, calmodulin instead! \newline Tropomyosin present. \newline Contract by sliding-filament mechanism. \newline No T-tubules. \newline Sarcoplasmic reticulum present.}  \tn 
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Activation of Smooth Muscle Contraction by Ca\textasciicircum{}+2\textasciicircum{}}}  \tn
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Single Unit Smooth Muscle}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 0 (+ 0)
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\mymulticolumn{1}{x{5.377cm}}{Cells respond to stimuli as a single unit due to connections via gap junctions = functional syncytium.  \newline Capable of generating pacemaker activity.  \newline Spontaneous AP from pacemaker SMC can propogate to non-pacemaker SMC due to gap junctions.  \newline Experience pacemaker potential and slow-wave potential. \newline Ex- GI tract walls, reproductive tract walls, urinary tract walls, walls of small blood vessels.}  \tn 
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\mymulticolumn{1}{x{5.377cm}}{SMCs that are activated by neuronal input.  \newline Cells respond to stimuli independently and contain few gap junctions.  \newline Ex- Walls of large blood vessels, large airways to lungs, muscles of the eye that adjust the lens, iris of the eye, base of hair follicles.}  \tn 
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Pacemaker vs. Slow-Wave Potential}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Excitation/Contraction Coupling in SMCs}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{Self or neuron excitation leads to Ca2+ entry from the extracellular space via VG channels.} \tn 
% Row Count 2 (+ 2)
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\mymulticolumn{1}{x{5.377cm}}{Ca2+ entry triggers internal release of Ca2+ from SR. \newline Ca2+ binds to calmodulin in cytosol. \newline Ca2+-calmodulin complex activates light chain myosin kinase (phosphorylates light chain of myosin).  \newline Phosphorylated myosin light chain binds to actin = activated cross-bridges.  \newline Removal of Ca2+ desphosphorylates myosin, dissociating it from actin.  \newline Gap junctions allow rapid spread of excitation between connected cells. \newline Contraction strength is directly proportional to cytosolic {[}Ca2+{]}.}  \tn 
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\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}