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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
%\usepackage[english,german,french,spanish,italian]{babel}              % Languages

% Document Info
\author{sam219}
\pdfinfo{
  /Title (antivirals.pdf)
  /Creator (Cheatography)
  /Author (sam219)
  /Subject (Antivirals Cheat Sheet)
}

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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Antivirals Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{sam219} via \textcolor{DarkBackground}{\uline{cheatography.com/201893/cs/45436/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}sam219 \\
  \uline{cheatography.com/sam219} \\
  \end{tabulary}
\vfill
\columnbreak
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  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 13th January, 2025.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
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% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anti-DNA viruses: Polymerase inhibitors.}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Nucleoside analogues with modified sugars.\{\{ac\}\}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{1) Acyclovir (Zovirax)} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Synthetic analog of deoxguanosine with an {\bf{acyclic sugar part.}}} \tn 
% Row Count 4 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Prodrug activated into triphosphate becoming a {\bf{competitive inhibitor to viral DNA polymerase}}.} \tn 
% Row Count 6 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Widely effective even to {\bf{Herpes virus}}.} \tn 
% Row Count 7 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{2) Famciclovir} \tn 
% Row Count 8 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Prodrug with enhanced bioavailability.} \tn 
% Row Count 9 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Approved for {\bf{herpes simplex \& herpes zoster. }}} \tn 
% Row Count 10 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Interfere with viral nucleic acid replication.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anti-DNA viruses: Polymerase inhibitors.}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Nucleoside analogues with heterocyclic basic moiety.\{\{ac\}\}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{1) Ribavirin} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Prodrug, broad spectrum {\bf{(against DNA \& RNA viruses)}}} \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Phosphorylated by kinases into triphospate-{}-\textgreater{} inhibits viral specific RNA, mRNA-{}-\textgreater{} No nucleic acid synthesis.} \tn 
% Row Count 8 (+ 3)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Less selective than acyclovir.}}} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anti-DNA viruses: translation inhibitors.}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{1) Interferon alfa} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Cellular glycoproteins. Broad spectrum antivirals and immunomodulatory.} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{MOA: bind to specific cell-surface receptors on infected cells, inhibiting transcription and translation.} \tn 
% Row Count 6 (+ 3)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Tested for {\bf{DNA virus infections and RNA HCV.}}} \tn 
% Row Count 7 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{\seqsplit{Anti-reteroviruses/Anti-HIV} agents}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{Nucleoside RT inhibitor} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{\{\{ac\}\} Zidovudine (ZDV, retrivir)} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Structurally related to deoxythymidine.} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Prodrug activated/converted by {\bf{cellular thymidine kinase}} into 5' triphosphate.} \tn 
% Row Count 5 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{MOA: Direct RT inhibition \& prevetns DNA chain elongation by attachment.} \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{\seqsplit{Anti-reteroviruses/Anti-HIV} agents}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{Non-nucleoside RT inhibitors} \tn 
% Row Count 1 (+ 1)
% Row 1
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\mymulticolumn{1}{x{5.377cm}}{Nevirapine (dipyrido-diazepine deriv.)\{\{ac\}\}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{MOA: binds to (hydrophobic) allosteric site on RT enzyme, thus disrupting the activity of the active site.} \tn 
% Row Count 5 (+ 3)
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{\seqsplit{Anti-reteroviruses/Anti-HIV} agents}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{HIV protease inhibitors.} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Saquinavir \{\{ac\}\}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{MOA: by HIV protease inhibition 1) prevents post-translation processing 2) releases immature viral particles.} \tn 
% Row Count 5 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{\seqsplit{Anti-reteroviruses/Anti-HIV} agents}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{HCV RNA-dependent RNA-polymerase inhibitor (NS5B inhibitor)} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Sofosbuvir (sovaldi)} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Prodrug for {\bf{HCV ttt}} (12 weeks)} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{MOA: activated in liver into triphospahte then inhibits NS5B protein RNA-dep. RNA polymerase which affects viral replication.} \tn 
% Row Count 7 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Anti-influenza agents}}  \tn
% Row 0
\SetRowColor{LightBackground}
Inhibitors of virus attachment, penetration \& uncoating. & Neuroaminidase inhibitors. \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
Amantadine \& Rimantadine \{\{ac\}\} & Oseltamivir (Tamiflu) \{\{ac\}\} \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
MOA: Inhibits penetration of viral particles and uncoating of the genetic material. & Prodrug activated in liver; usually a phosphate salt. \tn 
% Row Count 10 (+ 5)
% Row 3
\SetRowColor{white}
For {\bf{prophylaxis \& ttt of influenza A virus.}} & Inhibits the removal of sialic acid from the surface viral glycoprotein enzyme, neuraminidase. thus, decreases infective level of virus \& improves viral inactivation by respiratory mucus. \tn 
% Row Count 20 (+ 10)
% Row 4
\SetRowColor{LightBackground}
Tricyclic primary amines. & {\bf{Prophylaxis \& ttt of inflenza.}} \tn 
% Row Count 22 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}