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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
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% Document Info
\author{sam219}
\pdfinfo{
  /Title (anti-neoplastic-anti-cancer.pdf)
  /Creator (Cheatography)
  /Author (sam219)
  /Subject (Anti-neoplastic/anti-cancer Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Anti-neoplastic/anti-cancer Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{sam219} via \textcolor{DarkBackground}{\uline{cheatography.com/201893/cs/45447/}}}
\end{tabulary}
\end{multicols}}

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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}sam219 \\
  \uline{cheatography.com/sam219} \\
  \end{tabulary}
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\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 14th January, 2025.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{x{1.87657 cm} x{1.8308 cm} x{0.86963 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Alkylating agents}}  \tn
% Row 0
\SetRowColor{LightBackground}
Sulfur mustard\{\{ac\}\} & Nitrogen mustard/ 1)Meclorethamine\{\{ac\}\} & Nitrosurea\{\{ac\}\} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Given IV. & Streptoazocin\{\{ac\}\} \tn 
% Row Count 6 (+ 3)
% Row 2
\SetRowColor{LightBackground}
is converted into {\bf{episulfonuim ion}} attacked by nucleophile from cells and becomes alkylated biopolymer. & Becomes the unstable {\bf{aziridinuim ion}} and then gives alkylated biopolymer. &  \tn 
% Row Count 13 (+ 7)
% Row 3
\SetRowColor{white}
 & 2) Chlorambucil \{\{ac\}\} &  \tn 
% Row Count 15 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Relatively stable; given oral. &  \tn 
% Row Count 17 (+ 2)
% Row 5
\SetRowColor{white}
 & Least toxic, long-acting. &  \tn 
% Row Count 19 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & 3) Cyclophosamide\{\{ac\}\} &  \tn 
% Row Count 21 (+ 2)
% Row 7
\SetRowColor{white}
 & Active orally and parenterally. &  \tn 
% Row Count 23 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{5.377cm}}{Both sulfur and nitrogen mustard are converted into unstable 3-membered (onium) intermediates that they act by.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Plant products}}  \tn
% Row 0
\SetRowColor{LightBackground}
Vinca alkaloids\{\{ac\}\} & Ixabepilone \{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Include vincristine, vinblastine, vinrosidine, vinleurosine & semisynthetic amide analogue of the spindle poison, Epothilone B. \tn 
% Row Count 6 (+ 4)
% Row 2
\SetRowColor{LightBackground}
1) Paclitaxel (taxol) & Has lactam in its structure providing increased {\emph{invivo}} stability. \tn 
% Row Count 10 (+ 4)
% Row 3
\SetRowColor{white}
MOA: spindle poison inhibiting mitosis. & Uses: Metastatic breast cancer \tn 
% Row Count 12 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Uses: ttt of breast, ovarian \& {\bf{aids-related kaposi sarcoma}}.} \tn 
% Row Count 14 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Signal transduction (PK) inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
Imatinib mesylate\{\{ac\}\} & Sorafenib tosylate\{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
MOA: Competitive inhibition of TK-{}-\textgreater{} inducing {\bf{apoptosis or non-dividing cells.}} & MOA: Broad spectrum kinase inhibitor \tn 
% Row Count 7 (+ 5)
% Row 2
\SetRowColor{LightBackground}
Uses: CML, GIST, acute lymphoblastic leukemia (+ve philadelphia chromosomes) & Uses: renal cell carcinoma and colon cancer \tn 
% Row Count 11 (+ 4)
% Row 3
\SetRowColor{white}
SE: thrombocytopenis, skin rash, N/V, pulmonary edema. & SE: Skin rash, HTN, fatigue, increased risk of bleeding \& wound healing time. \tn 
% Row Count 15 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Advantage: Orally administered, better patient tolerability. \newline Disadvantage: Cardiotoxicity \newline  \newline {\bf{Resistance to tyrosine kinase forms}}: \newline - Altering amino a' to stop binding \newline - Increasing kinase levels \newline - Drug is substrate to efflux transporter, BCRP.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Anti-metabolites}}  \tn
% Row 0
\SetRowColor{LightBackground}
Pyrimidine \seqsplit{antimetabolites} & Purine \seqsplit{antimetabolites} & Folic a' \seqsplit{antimetabolites} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
1) 5-FU\{\{ac\}\} & 1) 6-MP\{\{ac\}\} & 1) Methotrexate\{\{ac\}\} \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
MOA: thymidylate synthase inhibitor or incorporated into RNA \& DNA. & Is {\emph{invivo}} converted into \seqsplit{6-thionosinate}. & MOA: \seqsplit{dihydrofolate} reductase inhibitor \tn 
% Row Count 10 (+ 6)
% Row 3
\SetRowColor{white}
2) Uracil mustard & MOA: inhibits the \seqsplit{rate-limiting} step during purine synthesis. & Uses: remission in leukaemia and breast cancer management. \tn 
% Row Count 15 (+ 5)
% Row 4
\SetRowColor{LightBackground}
Alkylating agent. & Uses: &  \tn 
% Row Count 17 (+ 2)
% Row 5
\SetRowColor{white}
MOA: Damages DNA that in take in uracil. & - with methotraxate for lymphocytic leukemia. &  \tn 
% Row Count 21 (+ 4)
% Row 6
\SetRowColor{LightBackground}
Uses: Non-hodgkins lymphoma & - \seqsplit{Immunosuppressive} for UC, psoriatic arthirits, systemic lopus \seqsplit{erythromatosis}. &  \tn 
% Row Count 28 (+ 7)
% Row 7
\SetRowColor{white}
 & Allopurinol potentiates its effect by inhibiting its metabolism. &  \tn 
% Row Count 33 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Miscellaneous compounds}}  \tn
% Row 0
\SetRowColor{LightBackground}
Platinum complexes\{\{ac\}\} & Synthetic retinoid analog\{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
1) Cisplatin & 1) Bexarotene \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
MOA: Cross-links DNA causing DNA conformational changes. & MOA: binds to activated retinoid X receptors in skin. \tn 
% Row Count 6 (+ 3)
% Row 3
\SetRowColor{white}
Uses: {\bf{with bleomycin \& vinblastine}} for metastatic testicular tumors. & Use: cutaneous T-cell lymphoma \tn 
% Row Count 10 (+ 4)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{2) Carboplatin} \tn 
% Row Count 11 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.46464 cm} x{1.55618 cm} x{1.55618 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Immunotherapy/monoclonal antibodies}}  \tn
% Row 0
\SetRowColor{LightBackground}
**Block\{\{ac\}\} & **Flag\{\{ac\}\} & **Deliver\{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
1) Trastuzumab & 1) Rituximab & 1) Brentuximab vedotin \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Blocks HER-2 receptors to stop growth. & chimeric (hybrid) monoclonal antibody. & Delivers chemotherapy drugs inside tumor cells. \tn 
% Row Count 8 (+ 4)
% Row 3
\SetRowColor{white}
2) Bevacizumab & Flag malignant B lymphocytes with CD20 receptor for the immune cells. &  \tn 
% Row Count 14 (+ 6)
% Row 4
\SetRowColor{LightBackground}
Blocks VEGF-{}-\textgreater{} no new blood vessels. & Use: Non-Hodgkins B-cell lymphoma. &  \tn 
% Row Count 17 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{5.377cm}}{MOA: targeted therapy by {\bf{selective binding on receptor to-{}-}}**}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Antibiotics}}  \tn
% Row 0
\SetRowColor{LightBackground}
Anthracyclines\{\{ac\}\} & Actinomycin\{\{ac\}\} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
1) Danorubicin HCl & 1) Bleomycin \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
MOA: intercalates into DNA causing indirect inhibition of topoisomerase II-{}-\textgreater{} decreased RNA \& DNA synthesis. & Has multiple heterocyclic rings and cytotoxic glycosides. \tn 
% Row Count 8 (+ 6)
% Row 3
\SetRowColor{white}
SE: Cardiotoxicity, release of hydroxyl and superoxide radicals. & MOA: Fragmentation of DNA. \tn 
% Row Count 12 (+ 4)
% Row 4
\SetRowColor{LightBackground}
2) Doxorubicin HCl & 2) Mitomycin C \tn 
% Row Count 13 (+ 1)
% Row 5
\SetRowColor{white}
Uses: Acute leukaemia, Hodgkins's disease & 3 anti-cancer functional gps: Quinone + Aziridine + Carbamate. \tn 
% Row Count 17 (+ 4)
% Row 6
\SetRowColor{LightBackground}
 & MOA: cross-links double helical DNA \tn 
% Row Count 19 (+ 2)
% Row 7
\SetRowColor{white}
 & Unreactive in natural state-{}-reduction-{}-\textgreater{} Indol-hydroquinone (bifunctional alkylating agent) \tn 
% Row Count 24 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Hormones}}  \tn
% Row 0
\SetRowColor{LightBackground}
Testolactone\{\{ac\}\} & Tamoxifen\{\{ac\}\} & Letrozole\{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
MOA: Aromatase inhibitor stopping estrogen synthesis from \seqsplit{testosterone.} & \seqsplit{Non-steroidal} agent with \seqsplit{anti-estrogen} properties. & MOA: Aromatase inhibitor \tn 
% Row Count 8 (+ 6)
% Row 2
\SetRowColor{LightBackground}
Uses: Breast cancer in \seqsplit{post-menopausal} women. & MOA: binds to estorgen receptors resulting in decreased DNA \seqsplit{transcription}. & Uses: locally advanced or metastatic breast cancer. \tn 
% Row Count 14 (+ 6)
% Row 3
\SetRowColor{white}
 & Uses: breast cancer in \seqsplit{post-menopausal} women. &  \tn 
% Row Count 18 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}