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% Document Info
\author{sam219}
\pdfinfo{
  /Title (anti-hypertensives.pdf)
  /Creator (Cheatography)
  /Author (sam219)
  /Subject (Anti-hypertensives Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
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    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Anti-hypertensives Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{sam219} via \textcolor{DarkBackground}{\uline{cheatography.com/201893/cs/42782/}}}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}sam219 \\
  \uline{cheatography.com/sam219} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 8th May, 2024.\\
   Page {\thepage} of \pageref{LastPage}.
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{x{1.08602 cm} x{1.04425 cm} x{1.00248 cm} x{1.04425 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{5.377cm}}{\bf\textcolor{white}{Renal tubular inhibitory diuretics}}  \tn
% Row 0
\SetRowColor{LightBackground}
CAI & Thiazide or \seqsplit{thiazide-like} diuretics & Loop \seqsplit{diuretics} & K sparring diuretics \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
Decreases H+ and Na ion exchange so Na remians in lumen and gets excreted with HCO3- and water. & In mild HTN alone or in edema caused by nephritic syndrome, liver cirrhosis, HF &  & Excrete Na \& Cl without K, which may lead to hyperkalemia-{}-caridac risk. \tn 
% Row Count 14 (+ 10)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{4}{x{5.377cm}}{Drug design concept originates from anti-bacterial {\bf{sulfanilamide}} (weak CAI)} \tn 
% Row Count 16 (+ 2)
% Row 3
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\mymulticolumn{4}{x{5.377cm}}{Two groups:} \tn 
% Row Count 17 (+ 1)
% Row 4
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1. \seqsplit{Heterocyclic} \seqsplit{sulfonamides;} {\bf{Acetazolamide, Methazolamide}} & {\bf{Hydrochlorothiazide}} or {\bf{Indapamide}}; thiazide like & \seqsplit{Furosemide;} \seqsplit{Azosemide;} \seqsplit{Ethacrynic} acid & \seqsplit{Spironolactone;} hormonal SE; \seqsplit{Amiloride:} less hormonal SE; \seqsplit{Triametrine} \tn 
% Row Count 24 (+ 7)
% Row 5
\SetRowColor{white}
\mymulticolumn{4}{x{5.377cm}}{2. Metadisulfamoyl benz deriv.;  Dichlorphenamide, Chloraminophenamide} \tn 
% Row Count 26 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\SetRowColor{LightBackground}
\mymulticolumn{4}{x{5.377cm}}{NOT given to sulpha-allergic patients: CAI- Thiazide Diuretics- Loop diuretics except ethacrynic a'}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}----}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Osmotic diuretics}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{Given in high concentrations to increase osmotic pressure in urine and increase its secretion into urine along with water.} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Decreases IOP} \tn 
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\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{1. Glycerine/glycerol} \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{2. Mannitol:{\bf{ Taken IV}}; Safe on kidney so for renal function diagnosis, acute renal failure or cerebral edema} \tn 
% Row Count 8 (+ 3)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{3. Sorbitol (D-glucitol)/Isosorbide} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Vasodilators}}  \tn
% Row 0
\SetRowColor{LightBackground}
Hydralazine HCl & Sodium \seqsplit{nitroprusside} & K channel agonists \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Best in combination to avoid individual increase in dose leading to unwanted SE. & Indicated for hypertensive emergencies (very potent VD) & Diazoxide: IV for emergency BP lowering in hospitalized pt. \tn 
% Row Count 9 (+ 7)
% Row 2
\SetRowColor{LightBackground}
 &  & Minoxidil: for severe HTN and alopecia. \tn 
% Row Count 12 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.89126 cm} x{3.08574 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Sympatholytic}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\emph{Affects central nerves:}} & {\emph{Affects peripheral nerves:}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
a-methyl dopa & Reserpine, guanethidine; deplete NT store \tn 
% Row Count 4 (+ 2)
% Row 2
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Clonidine & Prazosin: a1 antagonist \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
 & Propranolol, atenolol: B blockers \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{RAS inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
ACEI & ARBS \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Captopril: thiol gp attaches to Zn of the metalloenzyme and responsible for SE urticaria or rash & Candesartan: Prodrug that gives free acid from hydrolysis of ethyl ester \tn 
% Row Count 6 (+ 5)
% Row 2
\SetRowColor{LightBackground}
Gen2 (prodrugs): Lisinopril, Quinapril, Enalapril & Losartan (non-peptide imidazole): Orally active, potent, selective to AT1 on angiotensin II receptor. \tn 
% Row Count 12 (+ 6)
% Row 3
\SetRowColor{white}
{\bf{No thiol gp.}} . Long acting ACEI. & Valsartan \tn 
% Row Count 14 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}