\documentclass[10pt,a4paper]{article}

% Packages
\usepackage{fancyhdr}           % For header and footer
\usepackage{multicol}           % Allows multicols in tables
\usepackage{tabularx}           % Intelligent column widths
\usepackage{tabulary}           % Used in header and footer
\usepackage{hhline}             % Border under tables
\usepackage{graphicx}           % For images
\usepackage{xcolor}             % For hex colours
%\usepackage[utf8x]{inputenc}    % For unicode character support
\usepackage[T1]{fontenc}        % Without this we get weird character replacements
\usepackage{colortbl}           % For coloured tables
\usepackage{setspace}           % For line height
\usepackage{lastpage}           % Needed for total page number
\usepackage{seqsplit}           % Splits long words.
%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
%\usepackage[english,german,french,spanish,italian]{babel}              % Languages

% Document Info
\author{sam219}
\pdfinfo{
  /Title (anti-fungals.pdf)
  /Creator (Cheatography)
  /Author (sam219)
  /Subject (Anti-fungals Cheat Sheet)
}

% Lengths and widths
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\renewcommand{\headrulewidth}{0pt} % Remove header line
\renewcommand{\seqinsert}{\ifmmode\allowbreak\else\-\fi} % Hyphens in seqsplit
% This two commands together give roughly
% the right line height in the tables
\renewcommand{\arraystretch}{1.3}
\onehalfspacing

% Commands
\newcommand{\SetRowColor}[1]{\noalign{\gdef\RowColorName{#1}}\rowcolor{\RowColorName}} % Shortcut for row colour
\newcommand{\mymulticolumn}[3]{\multicolumn{#1}{>{\columncolor{\RowColorName}}#2}{#3}} % For coloured multi-cols
\newcolumntype{x}[1]{>{\raggedright}p{#1}} % New column types for ragged-right paragraph columns
\newcommand{\tn}{\tabularnewline} % Required as custom column type in use

% Font and Colours
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\renewcommand{\familydefault}{\sfdefault}
\color{TextColor}

% Header and Footer
\pagestyle{fancy}
\fancyhead{} % Set header to blank
\fancyfoot{} % Set footer to blank
\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
    }
\end{tabulary}
\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Anti-fungals Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{sam219} via \textcolor{DarkBackground}{\uline{cheatography.com/201893/cs/44925/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}sam219 \\
  \uline{cheatography.com/sam219} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 14th January, 2025.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
  \SetRowColor{white}
  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Agansit cell wall {\bf{Polyenes/macrocyclic lactone}}}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Nyastatin/Mycostatin} \{\{ac\}\} & Amphotericin B\{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
No oral \seqsplit{absorptiob/toxicity.} & {\bf{broadest spectrum}} of all antifungals. \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
Uses: GIT candidiasis. DOC for vaginal or cutaneous candidiais. & Uses: DOC for deep fungal infection \tn 
% Row Count 9 (+ 4)
% Row 3
\SetRowColor{white}
 & SE/toxicity: Phlebitis, nephrotoxicity. \tn 
% Row Count 11 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{MOA: integrate within cell wall ergosterols, causing leakage of small molecules. \newline Have higher affinity to fungal ergosterols than mammalian sterols.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Against fungal nucleus}}  \tn
% Row 0
\SetRowColor{LightBackground}
Griseofulvin \{\{ac\}\} & 5-fluorocytosine (Flucytosine) \{\{ac\}\} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Natural. Oral intake since topically inactive. & Synthetic pyrimidine analogue. \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
MOA: stops mitosis/M-phase & MOA: get incorporated into RNA, thus ruining protein synthesis. \tn 
% Row Count 9 (+ 4)
% Row 3
\SetRowColor{white}
{\bf{SAR:}} Has 2 stereocenters( Cl and C-O-CH3) & Prodrug activated by {\bf{fungal cytosine deaminase}} \tn 
% Row Count 12 (+ 3)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{-Cl can be replaced by fluorine only.} \tn 
% Row Count 13 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{-{\bf{Increased activity}}: if Methoxy becomes propoxy or butoxy {\emph{invitro}} due to increased lipophilicity. - {\bf{Decreased activity:}} if methoxy becomes NH2.} \tn 
% Row Count 17 (+ 4)
% Row 6
\SetRowColor{LightBackground}
Uses: agansit mycelial fungi only; fungistatic for growing dermatophytes (ringworm,tinea) & Uses: systemic fungal and candida infections. \tn 
% Row Count 22 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Affecting ergosterol biosynthesis}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Thiocarbamates\{\{ac\}\}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{MOA: inhibit squalene epoxidase.} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Tolnaftate\{\{ac\}\}} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Uses: topical for dermatophytes, Tinea cure, for skin mycoses such as athletes foot.} \tn 
% Row Count 5 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Not very effective for nail \& scalp mycoses.} \tn 
% Row Count 6 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
% Row Count 6 (+ 0)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
% Row Count 6 (+ 0)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
% Row Count 6 (+ 0)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}