\documentclass[10pt,a4paper]{article}

% Packages
\usepackage{fancyhdr}           % For header and footer
\usepackage{multicol}           % Allows multicols in tables
\usepackage{tabularx}           % Intelligent column widths
\usepackage{tabulary}           % Used in header and footer
\usepackage{hhline}             % Border under tables
\usepackage{graphicx}           % For images
\usepackage{xcolor}             % For hex colours
%\usepackage[utf8x]{inputenc}    % For unicode character support
\usepackage[T1]{fontenc}        % Without this we get weird character replacements
\usepackage{colortbl}           % For coloured tables
\usepackage{setspace}           % For line height
\usepackage{lastpage}           % Needed for total page number
\usepackage{seqsplit}           % Splits long words.
%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
%\usepackage[english,german,french,spanish,italian]{babel}              % Languages

% Document Info
\author{sam219}
\pdfinfo{
  /Title (anti-biotics.pdf)
  /Creator (Cheatography)
  /Author (sam219)
  /Subject (anti biotics Cheat Sheet)
}

% Lengths and widths
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\setlength{\tabcolsep}{0.2cm} % Space between columns
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\renewcommand{\footrulewidth}{0pt} % Remove footer line
\renewcommand{\headrulewidth}{0pt} % Remove header line
\renewcommand{\seqinsert}{\ifmmode\allowbreak\else\-\fi} % Hyphens in seqsplit
% This two commands together give roughly
% the right line height in the tables
\renewcommand{\arraystretch}{1.3}
\onehalfspacing

% Commands
\newcommand{\SetRowColor}[1]{\noalign{\gdef\RowColorName{#1}}\rowcolor{\RowColorName}} % Shortcut for row colour
\newcommand{\mymulticolumn}[3]{\multicolumn{#1}{>{\columncolor{\RowColorName}}#2}{#3}} % For coloured multi-cols
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\newcommand{\tn}{\tabularnewline} % Required as custom column type in use

% Font and Colours
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\definecolor{FootBackground}{HTML}{666666}
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\definecolor{DarkBackground}{HTML}{A3A3A3}
\definecolor{LightBackground}{HTML}{F3F3F3}
\renewcommand{\familydefault}{\sfdefault}
\color{TextColor}

% Header and Footer
\pagestyle{fancy}
\fancyhead{} % Set header to blank
\fancyfoot{} % Set footer to blank
\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
    }
\end{tabulary}
\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{anti biotics Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{sam219} via \textcolor{DarkBackground}{\uline{cheatography.com/201893/cs/44448/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}sam219 \\
  \uline{cheatography.com/sam219} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 26th October, 2024.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
  \SetRowColor{white}
  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{1.8 cm} x{1.8 cm} x{1.8 cm} x{1.8 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{8.4cm}}{\bf\textcolor{white}{Penicillin}}  \tn
% Row 0
\SetRowColor{LightBackground}
Natural \{\{ac\}\} & \seqsplit{Semisynthetic} \{\{ac\}\} & \seqsplit{Ampicillin} \seqsplit{ester/prodrug} & Active agansit \seqsplit{pseudomonas} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
1.{\bf{ Benzyl \seqsplit{penicillin} \seqsplit{(penicillin} G)}} & 1. {\bf{Ampicillin \& Amoxycillin}} & {\bf{Bacampicillin}} & {\bf{Carbenicillin-Ticaricillin-Sulbenicillin}} \tn 
% Row Count 8 (+ 5)
% Row 2
\SetRowColor{LightBackground}
Not suitable orally; \seqsplit{Resistance} occurs; narrow spectrum to G+ & Orally active due to EWG on acylamino side chain. & Ester from COOH prevents its ionization-{}-\textgreater{}increased \seqsplit{apsorption} & Have COOH \seqsplit{(acidic/polar)gp} that increases G- activity. \tn 
% Row Count 15 (+ 7)
% Row 3
\SetRowColor{white}
Can be in salts with organic amines to have longer duration but only IM: & 2. {\bf{Methicillin-Nafcillin-oxacillin}} & Broken down into active form in bacteria by estrase. & Ester prodrugs can be formed to increase oral activity. \tn 
% Row Count 23 (+ 8)
% Row 4
\SetRowColor{LightBackground}
Procaine \seqsplit{penicillin:} 12 Hr & \seqsplit{B-lactamase} resistant \seqsplit{penicillin} by R being a bulky gp that stearic hindrance \seqsplit{preventing} \seqsplit{attachment} of \seqsplit{B-lactamase}. &  &  \tn 
% Row Count 35 (+ 12)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{8.4cm}{x{1.8 cm} x{1.8 cm} x{1.8 cm} x{1.8 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{8.4cm}}{\bf\textcolor{white}{Penicillin (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
\seqsplit{Benzathine} \seqsplit{penicillin:} 2-3 weeks & \seqsplit{Methicillin} \& \seqsplit{Nafcillin:} Orally inactive. &  &  \tn 
% Row Count 5 (+ 5)
% Row 6
\SetRowColor{white}
 & \seqsplit{Oxacillin(s):} \seqsplit{B-lactamase} resistant + orally active &  &  \tn 
% Row Count 11 (+ 6)
% Row 7
\SetRowColor{LightBackground}
 & \seqsplit{Temocillin:} strong \seqsplit{B-lactamase} \seqsplit{resistance} but only parentral route. &  &  \tn 
% Row Count 18 (+ 7)
% Row 8
\SetRowColor{white}
 & 3. {\bf{Ampicillin \& amoxicillin}} &  &  \tn 
% Row Count 22 (+ 4)
% Row 9
\SetRowColor{LightBackground}
 & Broad spectrum (on G- too) because of a-amino gp as EWG and \seqsplit{increasing} \seqsplit{hydrophilicty.} &  &  \tn 
% Row Count 31 (+ 9)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{B-lactamase inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Clauvulinic acid-sulbactam} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Have a B-lactam ring but irreversibly alkylate the B-lactamase enzyme in a mechanism based inhibition.} \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Augmentin: Amoxicillin + Clavulinic acid} \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Unacyn: Ampicillin + sulbactam} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.016 cm} x{1.944 cm} x{1.296 cm} x{1.944 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{8.4cm}}{\bf\textcolor{white}{Tetracyclines}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Sancycline}} & {\bf{Democlocycline}} & {\bf{Minocycline}} & {\bf{Rolitetracycline}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
Natural parent compound; no clinical benefit & Natural, stable & \seqsplit{Semisynthetic} & Prodrug of N-mannich base of \seqsplit{tetracycline} \tn 
% Row Count 8 (+ 5)
% Row 2
\SetRowColor{LightBackground}
 & Starting compound for \seqsplit{minocycline} \seqsplit{semi-synthesis} & -For \seqsplit{red-bumbs} and \seqsplit{pimples} & \seqsplit{Semisynthsis} with \seqsplit{tetracycline} in a mannich reaction. \tn 
% Row Count 14 (+ 6)
% Row 3
\SetRowColor{white}
 &  & -For \seqsplit{bacterial} \seqsplit{infections} & - More soluble and less \seqsplit{irritating} than others so suitable as IV and IM \tn 
% Row Count 22 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Glycylcyclines}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{New class; lack the clinical resistance issues of tetracyclines} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Tigecycline "tygacil"}}: broad spectrum} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{used for complicated intra-abdominal infections} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Macrolide antibiotics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Large lactone ring of 12-17 atoms (macrolide) with 2 characteristic sugars attached to a 14-membered ring.} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Erythromycin:}} Given as a film coated tablet to avoid GI acid causing hemiketal formation. can also be given in iral suspension as erythromycin stearate salt.} \tn 
% Row Count 7 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Clarithromycin}}: more acid stability.} \tn 
% Row Count 8 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Azithromycin/Azalide}}: from semi-synthetic ring expansion of erythromycin in a Beckmann rearrangement.} \tn 
% Row Count 11 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{p{0.792 cm} x{2.592 cm} x{1.296 cm} x{2.52 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{8.4cm}}{\bf\textcolor{white}{Cephalosporins}}  \tn
% Row 0
\SetRowColor{LightBackground}
Gen 1 & Gen 2 & Gen 3 & Gen 4 \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Cepalexin}} & {\bf{Cefaclor}} & {\bf{Ceftibuten}} & {\bf{Cefpirome \& Cefepime}} \tn 
% Row Count 6 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{7-ADCA} \seqsplit{deriv.} & 7-ADCA deriv. & 7-ADCA & -{}- \tn 
% Row Count 10 (+ 4)
% Row 3
\SetRowColor{white}
\seqsplit{Orally} \seqsplit{active} & Orally active & Orally active & Parenteral only \tn 
% Row Count 14 (+ 4)
% Row 4
\SetRowColor{LightBackground}
 & {\bf{Cefuroxime}} & \seqsplit{B-lactamase} \seqsplit{resistant} & B-lactamse resistant \tn 
% Row Count 17 (+ 3)
% Row 5
\SetRowColor{white}
 & 7-ACA deriv. &  & Broad spectrum activity including p.aueroginosa, G+ and G-. \tn 
% Row Count 22 (+ 5)
% Row 6
\SetRowColor{LightBackground}
 & Not orally active (parenteral) &  &  \tn 
% Row Count 25 (+ 3)
% Row 7
\SetRowColor{white}
 & {\bf{Prodrug: Cefuroxime axetil}} &  &  \tn 
% Row Count 28 (+ 3)
% Row 8
\SetRowColor{LightBackground}
 & COOH becomes an ester with axetil gp that increases lipophilicty-{}-\textgreater{} better oral \seqsplit{bioavialability} &  &  \tn 
% Row Count 35 (+ 7)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Carbapenems}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Thienamycin}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{B-lactamase resistant: Alpha-hydroxyethyl side chain at position 6.} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Natural, broad spectrum, B-lactamase resistant and inhibitor} \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Unstable; Susceptible to in-vivo deactivation by DHP-1 (t1/2=30sec)} \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
% Row Count 7 (+ 0)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{\seqsplit{Aminoglycosides/aminocyclitols}}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{protein synthesis inhibitors.} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Water-soluble that must be given parenteral for systemic effect but can be given orally for a local GIT anti-septic effect.} \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Streptomycin}}} \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Drug-drug interaction: \{\{ac\}\}} \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Aminoglycosides + B-lactam= inactive compound that results in hearing loss, ototoxicity \& nephrotoxicity.} \tn 
% Row Count 9 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}