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\usepackage{seqsplit}           % Splits long words.
%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
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% Document Info
\author{sam219}
\pdfinfo{
  /Title (adrenergic-drugs-ans.pdf)
  /Creator (Cheatography)
  /Author (sam219)
  /Subject (Adrenergic drugs(ANS) Cheat Sheet)
}

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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Adrenergic drugs(ANS) Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{sam219} via \textcolor{DarkBackground}{\uline{cheatography.com/201893/cs/42828/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}sam219 \\
  \uline{cheatography.com/sam219} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 8th May, 2024.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
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\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{x{1.00248 cm} x{1.08602 cm} x{1.04425 cm} x{1.04425 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{5.377cm}}{\bf\textcolor{white}{Alpha agonists}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{-Phenylephrine-} & \seqsplit{-Imidazolines} \seqsplit{(Naphazoline;} \seqsplit{Xylometazoline)-} & \seqsplit{-Clonidine-} & -a-methyl dopa- \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
\seqsplit{Selective} a1 \seqsplit{agonist...VC} & Safe nasal \seqsplit{decongestant} (doesn't cross BBB) & Acts on brain a2 receptors to cause \seqsplit{long-phase} \seqsplit{hypotension} & Becomes a-methyl NE and acts on a2 receptors to decrease release of NE from brain. \tn 
% Row Count 14 (+ 9)
% Row 2
\SetRowColor{LightBackground}
Used as nasal \seqsplit{decongestant}, \seqsplit{mydriatic} &  & Centrally acting \seqsplit{antihypertensive} agent & \seqsplit{Sympatholytic} used as \seqsplit{antihypertensive} agent. \tn 
% Row Count 19 (+ 5)
% Row 3
\SetRowColor{white}
\mymulticolumn{4}{x{5.377cm}}{Orally active.} \tn 
% Row Count 20 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{B2 agonists}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Terbutaline} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Not metabolized by COMT or MAO} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 2 (+ 0)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{} \tn 
% Row Count 2 (+ 0)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{All are bronchodilators used for treatment of asthma. \newline Long acting b2 agonist should not be given as monotherapy.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{B agonist}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{-Isoproterenol- \{\{ac\}\}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{acts on B1 \& B2 receptors.} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{B1: positive cardiotropic side effect} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{B2: {\bf{Bronchodilation}}} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{As inhalation, injection or {\emph{sublingual}}} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.3731 cm} x{1.64772 cm} x{1.55618 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Catecholamines biosynthesis inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Metyrosine}}(a-methyl tyrosine) & {\bf{Reserpine}} "{\emph{Rawlfia alk.}}" & {\bf{Guanethidine \& Guanadrel}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
Inhibits tyrosine hydroxylase & Inhibits neuronal reuptake of NE \& Seretonin & Inhibit U2 of NE \tn 
% Row Count 7 (+ 4)
% Row 2
\SetRowColor{LightBackground}
 & Passes BBB & Don't pass BBB (due to high polarity) \tn 
% Row Count 10 (+ 3)
% Row 3
\SetRowColor{white}
 & Used for VD & Used for VD \tn 
% Row Count 11 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{5.377cm}}{Side effects:} \tn 
% Row Count 12 (+ 1)
% Row 5
\SetRowColor{white}
 & 1. Mental depression & no CNS side effects \tn 
% Row Count 14 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & 2. Impotence &  \tn 
% Row Count 15 (+ 1)
% Row 7
\SetRowColor{white}
 & 3. Breast cancer &  \tn 
% Row Count 17 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{SAR of direct acting sympathomimetics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{B-OH group: in NE \& E makes the molecule {\bf{chiral}} and thus, {\bf{the (-)(R) enantiomer is the most potent }}due to attachment of the OH on 3 receotor binding sites instead of 2.} \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Phenolic OH\{\{ac\}\}} \tn 
% Row Count 5 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Resorcinol (such in metaproterenol) increases B2 selectivity and results in longer activity duration.} \tn 
% Row Count 8 (+ 3)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Replacing one phenolic OH with CH2OH results in albuterol/salbutamol, which increases B2 selectivity and longer action duration.} \tn 
% Row Count 11 (+ 3)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Removal of the para-OH, such as in phenylephrine, results in a1 agonist.} \tn 
% Row Count 13 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{N-atom\{\{ac\}\}} \tn 
% Row Count 14 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Essential for alpha receptor activity.} \tn 
% Row Count 15 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Bulky gp on N-atom results in decreased a-activity.} \tn 
% Row Count 17 (+ 2)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{alpha-carbon substitution\{\{ac\}\}} \tn 
% Row Count 18 (+ 1)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Decreases direct receptor agonist activity, but increases a2 and B2 selectivity if a-methyl gp.} \tn 
% Row Count 20 (+ 2)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Increases oral absorption, duration and CNS activity.} \tn 
% Row Count 22 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Beta Blockers}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{-Propranolol {\emph{arlyoxypropanol amine}} - for treatment of HTN, angina and arrythmia-but it is {\bf{non-cardio selective}} (acts on B1 \& B2)} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-Timolol-treatment to glaucoma} \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{both may have SE broncho-constriction due to non-selectivity. \{\{bb\}\}} \tn 
% Row Count 6 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Cardio selective BB (B1 blockers): Atenolol, Acebutolol}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{a1 antagonists: Quinazolines}}  \tn
% Row 0
\SetRowColor{LightBackground}
-Prazocin-\{\{ac\}\} & -Tamsulosin- \{\{ac\}\} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Structure has NH2 gp on quinazoline ring responsible for a1 receptor antagonism. & Relaxes muscles of prostate. \tn 
% Row Count 5 (+ 4)
% Row 2
\SetRowColor{LightBackground}
Used for HTN and BPH. & Used for BPH, {\bf{chronic prostatitis}}, for passage of kidney stones. \tn 
% Row Count 9 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{a2 antagonists are indole alkaloids.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}