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% Most of the following are not required for the majority
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% Document Info
\author{ryhussein}
\pdfinfo{
  /Title (pharmacology-lec-1.pdf)
  /Creator (Cheatography)
  /Author (ryhussein)
  /Subject (pharmacology lec 1 Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{pharmacology lec 1 Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{ryhussein} via \textcolor{DarkBackground}{\uline{cheatography.com/165684/cs/34687/}}}
\end{tabulary}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}ryhussein \\
  \uline{cheatography.com/ryhussein} \\
  \end{tabulary}
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\columnbreak
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  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 15th October, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{nature of the drug}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- appropriate size} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- electrical charge} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{-shape} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{-atomic composition} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{pharmacokinetics (ADME)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{A}}bsorption} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{D}}istribution} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{M}}etabolism} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{E}}xcretion} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.2 cm} x{4.8 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{oral route}}  \tn
% Row 0
\SetRowColor{LightBackground}
advantages** & {\bf{disadvantages}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
easy & slow effect \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
safe & destruction by GIT \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
self use & first pass effect \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
convenient & food-drug interaction \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
cheap & drug-drug interaction \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
no need for sterilization & not suitable for uncurious, emergency \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.12 cm} x{4.88 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{sublingual administration}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{advantages}} & {\bf{disadvantages}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
rapid effect & not for irritant drugs \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{no first pass metabolism} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{high bioavailability} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{no GIT destruction} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{bo food-drug interaction} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4.8 cm} x{3.2 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{parental administration}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Advantages}} & {\bf{Disadvantages}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
high bioavailability & infectious \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
rapid action & sterilization \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
no first pass metabolism & pain \tn 
% Row Count 5 (+ 1)
% Row 4
\SetRowColor{LightBackground}
no food-drug interactions & need skill \tn 
% Row Count 7 (+ 2)
% Row 5
\SetRowColor{white}
no gastric interaction & anaphylaxis \tn 
% Row Count 8 (+ 1)
% Row 6
\SetRowColor{LightBackground}
suitable for emergency & expensive \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.68 cm} x{4.32 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{inhalation}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Advantages}} & {\bf{Disadvantages}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Rapid absorption area) & Only few drugs can be used \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Rapid effects as IV bolus} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{Provide local action} \tn 
% Row Count 5 (+ 1)
% Row 4
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\mymulticolumn{2}{x{8.4cm}}{Minor systemic effect} \tn 
% Row Count 6 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{low bioavailability} \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Less side effects.} \tn 
% Row Count 8 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{No first pass effect} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Dosage form: Aerosol, Nebulizer}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.92 cm} x{4.08 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{rectal administration}}  \tn
% Row 0
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{\bf{Advantages}} & {\bf{Disadvantages}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Vomiting \& children. \&unconsciousness & Irregular absorption \& bioavailability \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
irritant and bad tasting drugs & Irritation of rectal mucosa \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
less first pass metabolism & Not a well accepted route \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{dosage form: suppository or enema}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{transdermal administration}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Advantages}} & {\bf{Disadvantages}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
bypass first pass effect & allergy to patches \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
convenient and painless & drugs must be highly lipophilic \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
ideal for drugs that are lipophilic and have poor oral bioavailability & delayed delivery of drugs \tn 
% Row Count 9 (+ 4)
% Row 4
\SetRowColor{LightBackground}
 & limited to drugs taken in small daily dosages \tn 
% Row Count 12 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{topical application}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{rate of absorption depends on: physical characteristics of skin at site of application and lipid solubility of the drug% Row Count 3 (+ 3)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{mechanisms of drug absoption}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{simple diffusion= passive diffusion} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{active transport} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{facilitated diffusion} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{pinocytosis (endocytosis)} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{simple or passive diffusion characters}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{common} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{occurs along conc gradient} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{non selective} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{not saturable} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{low structural specificity} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{no energy} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{no carrier is needed} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{depends on lipid solubility} \tn 
% Row Count 8 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{depends on pKa of drug- pH medium} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{active transport characters}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{unusual} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{occurs against conc gradient} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{selective} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{saturable} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{require energy} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{carrier is needed (protein)} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{iron absorption} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{uptake of levodopa by brain} \tn 
% Row Count 8 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{facilitated diffusion characters}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{occurs along conc gradient} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{selective} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{saturable} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{no energy is required} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{carrier is needed (protein)} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{factors influencing aborption}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. Effect of pH on drug absorption \newline % Row Count 1 (+ 1)
2. Blood flow to the absorption site \newline % Row Count 2 (+ 1)
3. Total surface area available for absorption 4. Contact time at the absorption surface \newline % Row Count 4 (+ 2)
5. Expression of P-glycoprotein; transmembrane transporter protein. transport drugs from tissue to blood% Row Count 7 (+ 3)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}