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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
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% Document Info
\author{RUUUU (ruuuu538)}
\pdfinfo{
  /Title (alzheimer-disease.pdf)
  /Creator (Cheatography)
  /Author (RUUUU (ruuuu538))
  /Subject (Alzheimer Disease Cheat Sheet)
}

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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Alzheimer Disease Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{RUUUU (ruuuu538)} via \textcolor{DarkBackground}{\uline{cheatography.com/180027/cs/38049/}}}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}RUUUU (ruuuu538) \\
  \uline{cheatography.com/ruuuu538} \\
  \end{tabulary}
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\columnbreak
\begin{tabulary}{5.8cm}{L}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 1st April, 2023.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
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% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{4}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Etiology}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{•	Cortical atrophy and loss of neurons} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Risk Factors}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{•	{\bf{Age: }}prevalence doubles for every decade after age 60 \newline % Row Count 2 (+ 2)
•	{\bf{Family history:}} genetic mutations \newline % Row Count 3 (+ 1)
•	{\bf{Gender: }}more common in women \newline % Row Count 4 (+ 1)
•	{\bf{Exposures: }}head trauma, high cholesterol, lack of mental stimulation% Row Count 6 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Pathogenesis}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{•	Neurofibrillary tangles and amyloid plaques \newline % Row Count 1 (+ 1)
•	Amyloid plaques form from imbalance of production and removal of amyloid beta \newline % Row Count 3 (+ 2)
•	Decreased cholinergic transmission \newline % Row Count 4 (+ 1)
           o	Decreased acetylcholine production \newline % Row Count 5 (+ 1)
•	Results in the noticeable atrophy% Row Count 6 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{p{0.65825 cm} p{0.65825 cm} p{0.65825 cm} p{0.65825 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{3.833cm}}{\bf\textcolor{white}{Manifestations}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{4}{x{3.833cm}}{Alzheimer disease has also been described using four words that begin with A:} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Amnesia & Aphasia & Apraxia & Agnosia \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\SetRowColor{LightBackground}
\mymulticolumn{4}{x{3.833cm}}{•	Loss of short-term memory \newline •	Difficulty with language \newline •	Behavioral changes \newline •	7 stages of progressive degenerative changes}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
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\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Complications}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{•	Related to declining cognitive function \newline % Row Count 1 (+ 1)
•	Bowel and bladder incontinence \newline % Row Count 2 (+ 1)
•	Depression \newline % Row Count 3 (+ 1)
•	Falls {[}hip fractures @ high risk{]} \newline % Row Count 4 (+ 1)
•	Infections \newline % Row Count 5 (+ 1)
•	Malnutrition and dehydration {[}forgetting to eat \& drink{]}% Row Count 7 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
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\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Diagnosis}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{•	Not definitive until after death \newline % Row Count 1 (+ 1)
~ Requires a brain biopsy or autopsy \newline % Row Count 2 (+ 1)
•	{\bf{Presumptive diagnosis based on:}} \newline % Row Count 3 (+ 1)
~ Review of symptoms with patient and family \newline % Row Count 4 (+ 1)
~ Cognitive tests (MMSE, mini-cog, etc.) \newline % Row Count 5 (+ 1)
~ Imaging: CT, MRI, PET \newline % Row Count 6 (+ 1)
~ To rule out other pathology% Row Count 7 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{3.833cm}{X}
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\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Treatment}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{•	No definitive treatment or cure \newline % Row Count 1 (+ 1)
•	Medications may slow progression \newline % Row Count 2 (+ 1)
•	Other meds to control some symptoms (depression, sleep disturbances, agitation)% Row Count 4 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{3.833cm}{p{0.7899 cm} x{1.3165 cm} p{0.2633 cm} p{0.2633 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{3.833cm}}{\bf\textcolor{white}{Stages of Alzheimer Disease Progression}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Preclinical:}} changes in brain that do not result in noticeable \seqsplit{signs/symptoms} & {\bf{Stage 1 (mild)}} detected w/ screening tool &  &  \tn 
% Row Count 7 (+ 7)
% Row 1
\SetRowColor{white}
{\bf{Stage 2 (moderate)  }} pronounced changes & {\bf{Stage 3 (Severe)}} &  &  \tn 
% Row Count 11 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
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\par\addvspace{1.3em}

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\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{•	Preclinical}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{changes in brain that do not result in noticeable signs/symptoms} \tn 
% Row Count 2 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{o	can last for years}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Stage 1 (mild)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{Can be detected w/ the use of screening tools} \tn 
% Row Count 1 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{o	Coming up with the right word or name. \newline o	Remembering names when introduced to new people. \newline o	Having difficulty performing tasks in social or work settings. \newline o	Forgetting material that was just read. \newline o	Losing or misplacing a valuable object. \newline o	Experiencing increased trouble with planning or organizing. \newline o	If identified, this is the stage where they should be placing things in order in the event it progresses fast \newline 	Financial situation, POA, medical directives, living situation, etc.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
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\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Stage 2 (moderate)}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{o	Being forgetful of events or personal history. \newline % Row Count 1 (+ 1)
o	Feeling moody or withdrawn, especially in socially or mentally challenging situations. \newline % Row Count 3 (+ 2)
o	Being unable to recall information about themselves like their address or telephone number, and the high school or college they attended. \newline % Row Count 6 (+ 3)
o	Experiencing confusion about where they are or what day it is. \newline % Row Count 8 (+ 2)
o	Requiring help choosing proper clothing for the season or the occasion. \newline % Row Count 10 (+ 2)
o	Having trouble controlling their bladder and bowels. \newline % Row Count 12 (+ 2)
o	Experiencing changes in sleep patterns, such as sleeping during the day and becoming restless at night. \newline % Row Count 15 (+ 3)
o	Showing an increased tendency to wander and become lost. \newline % Row Count 17 (+ 2)
o	Demonstrating personality and behavioral changes, including suspiciousness and delusions or compulsive, repetitive behavior like hand-wringing or tissue shredding.% Row Count 21 (+ 4)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Stage 3 (Severe)}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{o	Require around-the-clock assistance with daily personal care. \newline % Row Count 2 (+ 2)
o	Lose awareness of recent experiences as well as of their surroundings. \newline % Row Count 4 (+ 2)
o	Experience changes in physical abilities, including walking, sitting and, eventually, swallowing \newline % Row Count 6 (+ 2)
o	Have difficulty communicating. \newline % Row Count 7 (+ 1)
o	Become vulnerable to infections, especially pneumonia.% Row Count 9 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Drugs Used to Treat Alzheimer Disease}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{} \tn 
% Row Count 0 (+ 0)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
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\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Cholinesterase Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{Prototype:{\bf{ Donepezil}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{prevent the breakdown of the neurotransmitter acetylcholine} \tn 
% Row Count 3 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{o	Reversible cholinesterase inhibitor that causes elevated levels of acetylcholine (ACh) in the cerebral cortex which slows the neuronal degradation of Alzheimer disease \newline o	Not a cure it ONLY improves cognition \& memory \newline o	Slows effects of Alzheimer's but will NOT stop the disease \newline o	Adverse effects: insomnia, fatigue, rash, N/V/D, dyspepsia, abdominal pain, muscle cramps}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{N-Methyl-D-aspartate (NMDA) Antagonist}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{Protype: {\bf{Memantine}} \newline % Row Count 1 (+ 1)
o	Memantine is used to treat moderate-to-severe Alzheimer's disease, especially for people who are intolerant of or have a contraindication to cholinesterase inhibitors \newline % Row Count 5 (+ 4)
o	A dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is hypothesized to be involved in the etiology of Alzheimer disease.  \newline % Row Count 9 (+ 4)
Adverse effects: \newline % Row Count 10 (+ 1)
o	Confusion \newline % Row Count 11 (+ 1)
o	Dizziness \newline % Row Count 12 (+ 1)
o	Drowsiness \newline % Row Count 13 (+ 1)
o	Headache \newline % Row Count 14 (+ 1)
o	Insomnia \newline % Row Count 15 (+ 1)
o	Agitation \newline % Row Count 16 (+ 1)
o	Hallucinations \newline % Row Count 17 (+ 1)
o	Less common adverse effects include vomiting, anxiety, hypertonia, cystitis, and increased libido.% Row Count 19 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{antagonizes (inhibits) NMDA (glutamate) receptors}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}