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% Document Info
\author{ravenchan}
\pdfinfo{
  /Title (unfinished-hemostasis-and-coagulation.pdf)
  /Creator (Cheatography)
  /Author (ravenchan)
  /Subject ((UNFINISHED) Hemostasis and Coagulation Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{(UNFINISHED) Hemostasis and Coagulation Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{ravenchan} via \textcolor{DarkBackground}{\uline{cheatography.com/181990/cs/42649/}}}
\end{tabulary}
\end{multicols}}

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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}ravenchan \\
  \uline{cheatography.com/ravenchan} \\
  \end{tabulary}
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\begin{tabulary}{5.8cm}{L}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 7th March, 2024.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{BLOOD VESSEL}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{CONNECTIVE TISSUE:}} & Fibroblasts \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Smooth Muscle Cells \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & {\emph{These cells secrete COLLAGEN - a negatively charged substance; platelet agonist}} \tn 
% Row Count 7 (+ 4)
% Row 3
\SetRowColor{white}
{\bf{BASEMENT MEMBRANE:}} & Collagen-rich {\emph{(from CT)}} \tn 
% Row Count 9 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Serves as support of endothelial lining \tn 
% Row Count 11 (+ 2)
% Row 5
\SetRowColor{white}
{\bf{ENDOTHELIAL LINING:}} & Secretes {\bf{Heparan Sulfate}} \tn 
% Row Count 13 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & {\emph{- an natural anticoagulant to keep blood flowing without turbulence in intact subendothelium}} \tn 
% Row Count 17 (+ 4)
% Row 7
\SetRowColor{white}
 & {\emph{- heparan sulfate is inactivated by {\bf{B-thromboglobulin and Platelet Factor 4}} for hemostasis to proceed}} \tn 
% Row Count 22 (+ 5)
% Row 8
\SetRowColor{LightBackground}
 & {\emph{- {\bf{Zeta potential}} is also responsible for keeping platelets from touching the subendothelium}} \tn 
% Row Count 26 (+ 4)
% Row 9
\SetRowColor{white}
{\bf{Zeta Potential:}} & Platelets: Phospholipids \seqsplit{(phosphotidylethanolamine)} \tn 
% Row Count 29 (+ 3)
% Row 10
\SetRowColor{LightBackground}
 & Endothelial Lining: Collagen (from CT) \tn 
% Row Count 31 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\emph{- A platelet is a negatively charged cell (from phospholipids) that can be activated by negatively-charged substances called {\bf{PLATELET AGONISTS}}}}}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{PLATELET FUNCTIONS}}  \tn
% Row 0
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\mymulticolumn{1}{x{8.4cm}}{{\bf{1. ADHESION:}}} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Adhered Platelets: single-layer of platelets} \tn 
% Row Count 2 (+ 2)
% Row 1
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\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Collagen-stimulated adhesion} \tn 
% Row Count 3 (+ 1)
% Row 2
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\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}{\bf{Platelet \textgreater{} GP Ib/IX \textgreater{} vWF \textgreater{} Collagen}}} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}(Platelets have a GP Ib/IX binding site on their membrane that von Willebrand Factor attaches to, to form a bridge between platelets and collagen — found on the subendothelium)} \tn 
% Row Count 8 (+ 4)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{2. SECRETION:}}} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Adhered platelets secrete DENSE GRANULES} \tn 
% Row Count 10 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}ADP (from dense granules) recruit \& activate surrounding inert platelets} \tn 
% Row Count 12 (+ 2)
% Row 6
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\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}(Adhered platelets are REactivated by {\bf{thromboxane A2}} to secrete granules thru OCS)} \tn 
% Row Count 14 (+ 2)
% Row 7
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\mymulticolumn{1}{x{8.4cm}}{{\bf{3. AGGREGATION:}}} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}ADP-stimulated Platelets expose {\bf{GP IIb/IIIa}}} \tn 
% Row Count 16 (+ 2)
% Row 8
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\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Fibrinogen attaches to GP IIb/IIIa} \tn 
% Row Count 17 (+ 1)
% Row 9
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\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}{\bf{Primary Platelet Plug}} is formed (loose clot)} \tn 
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% Row 10
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\mymulticolumn{1}{x{8.4cm}}{} \tn 
\mymulticolumn{1}{x{8.4cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}(Fibrinogen bridges the GP IIb/IIIa binding sites of each platelet to create {\bf{long spiny projections}} that indicate activation, and lead to aggregation)} \tn 
% Row Count 23 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\emph{- Platelet functions {\bf{always}} have to be enumerated in order}} \newline {\emph{- The 3 functions comprise the events of {\bf{PRIMARY HEMOSTASIS}}, meaning its output is a {\bf{primary platelet plug}}}}}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.76 cm} x{4.24 cm} }
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{PLATELET AGONISTS}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{ARACHIDONIC ACID}} & {\bf{{\emph{- strongest platelet agonist}}}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & {\emph{without this, secretion cannot happen = no ADP-stimulated platelets, and no primary platelet plug formation}} \tn 
% Row Count 8 (+ 6)
% Row 2
\SetRowColor{LightBackground}
{\bf{THROMBOXANE A2}} & {\bf{{\emph{- stimulates secretion}}}} \tn 
% Row Count 10 (+ 2)
% Row 3
\SetRowColor{white}
 & {\emph{it reactivates the adhered platelets to secrete granules}} \tn 
% Row Count 13 (+ 3)
% Row 4
\SetRowColor{LightBackground}
{\bf{ADENOSINE DIPHOSPHATE}} & {\bf{{\emph{- stimulates aggregation}}}} \tn 
% Row Count 15 (+ 2)
% Row 5
\SetRowColor{white}
 & {\emph{from dense granules; causes the aggregation of platelets to form a primary platelet plug = {\bf{ADP-stimulated Platelets}}}} \tn 
% Row Count 21 (+ 6)
% Row 6
\SetRowColor{LightBackground}
{\bf{THROMBIN (agonist \& Factor IIa)}} & {\bf{{\emph{- most important protease enzyme}}}} \tn 
% Row Count 23 (+ 2)
% Row 7
\SetRowColor{white}
{\bf{COLLAGEN}} & {\bf{{\emph{- electronegativity in connective tissue}}}} \tn 
% Row Count 26 (+ 3)
% Row 8
\SetRowColor{LightBackground}
 & *source of negative charge in connective tissue -\textgreater{} epithelial lining \tn 
% Row Count 30 (+ 4)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{8.4cm}{x{3.76 cm} x{4.24 cm} }
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{PLATELET AGONISTS (cont)}}  \tn
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\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{EPINEPHERINE}}} \tn 
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\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{THROMBOXANE A2 AND ARACHIDONIC ACID PATHWAY}}  \tn
\SetRowColor{LightBackground}
\mymulticolumn{1}{p{8.4cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/ravenchan_1709811233_IMG_0467.jpeg}}} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\emph{This pathway shows what happens upon injury to blood vessel}}}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}