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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
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% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
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% Document Info
\author{rachelk}
\pdfinfo{
  /Title (rheumatoid-arthritis.pdf)
  /Creator (Cheatography)
  /Author (rachelk)
  /Subject (Rheumatoid Arthritis Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
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    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Rheumatoid Arthritis Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{rachelk} via \textcolor{DarkBackground}{\uline{cheatography.com/164180/cs/34396/}}}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}rachelk \\
  \uline{cheatography.com/rachelk} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 28th September, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
\raggedright
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% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Overview of RA}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Definition}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Complex systemic inflammatory condition manifesting initially as symmetric swollen and tender joints of the hands and/or feet} \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{\{\{bl=3\}\}RA effects \textasciitilde{}1\% of the worlds population} \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{\{\{bl=3\}\}RA arises from an immunologic reaction} \tn 
% Row Count 6 (+ 1)
% Row 4
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\mymulticolumn{1}{x{5.377cm}}{\{\{bl=3\}\}May be in response to genetic or infectious antigen} \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Managing established RA}}  \tn
% Row 0
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\mymulticolumn{2}{x{5.377cm}}{} \tn 
% Row Count 0 (+ 0)
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Risk factors}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{Female gender (3:1 female to males)} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Increasing age (peak onset 35-50 years of age)} \tn 
% Row Count 2 (+ 1)
% Row 2
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\mymulticolumn{1}{x{5.377cm}}{Current tobacco smoking} \tn 
% Row Count 3 (+ 1)
% Row 3
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\mymulticolumn{1}{x{5.377cm}}{Family history of RA} \tn 
% Row Count 4 (+ 1)
% Row 4
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\mymulticolumn{1}{x{5.377cm}}{Potential environmental exposures} \tn 
% Row Count 5 (+ 1)
% Row 5
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\mymulticolumn{1}{x{5.377cm}}{Drugs - oral contraceptive use, high ingestion of vitamin D} \tn 
% Row Count 7 (+ 2)
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Managing Early RA}}  \tn
% Row 0
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\mymulticolumn{2}{x{5.377cm}}{} \tn 
% Row Count 0 (+ 0)
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Normal Joints vs RA Joints}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Normal Joints}} & {\bf{RA Joints}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Normal, thin synovium surrounding joint space & Synovial thickening, leading to panes formation \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
Intact tendons and ligaments & Loosening of tendon sheath and other periarticular structures, leading to joint deformities \tn 
% Row Count 9 (+ 5)
% Row 3
\SetRowColor{white}
Well-defined joint space & Joint space narrowing \tn 
% Row Count 11 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Smooth, intact cartilage surfaces providing protection to bone & Erosion of articular surfaces, leading t bone erosion and osteoporosis \tn 
% Row Count 15 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Biologic DMARDs}}  \tn
% Row 0
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% Row Count 0 (+ 0)
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\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Non-biologic DMARDs}}  \tn
% Row 0
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% Row Count 0 (+ 0)
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\begin{tabularx}{5.377cm}{p{0.4577 cm} x{1.96811 cm} x{2.15119 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{Comorbidities \& Impact on Morbidity/Mortality}}  \tn
% Row 0
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\mymulticolumn{3}{x{5.377cm}}{Cardiovascular disease} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
 & \{\{bl=3\}\} 1/2 of RA deaths are cardiac in nature &  \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & \{\{bl=3\}\} Inflammation happens in places other than joints, including blood vessels &  \tn 
% Row Count 9 (+ 5)
% Row 3
\SetRowColor{white}
\mymulticolumn{3}{x{5.377cm}}{Infections} \tn 
% Row Count 10 (+ 1)
% Row 4
\SetRowColor{LightBackground}
 & \{\{bl=3\}\} RA leads to changes in cellular immunity and increases in infection risk &  \tn 
% Row Count 15 (+ 5)
% Row 5
\SetRowColor{white}
\mymulticolumn{3}{x{5.377cm}}{Malignancy} \tn 
% Row Count 16 (+ 1)
% Row 6
\SetRowColor{LightBackground}
 & \{\{bl=3\}\} Patients with RA have increase risk of cancer &  \tn 
% Row Count 20 (+ 4)
% Row 7
\SetRowColor{white}
 &  & Lymphoma, leukemia, multiple myeloma \tn 
% Row Count 22 (+ 2)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{5.377cm}}{Osteoporosis} \tn 
% Row Count 23 (+ 1)
% Row 9
\SetRowColor{white}
 & \{\{bl=3\}\} RA causes increase in osteoclastic activity &  \tn 
% Row Count 27 (+ 4)
% Row 10
\SetRowColor{LightBackground}
 &  & Leads to bone loss \tn 
% Row Count 28 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}