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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
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% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
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% Document Info
\author{olkimmilo}
\pdfinfo{
  /Title (protein-synthesis-inhibitors.pdf)
  /Creator (Cheatography)
  /Author (olkimmilo)
  /Subject (PROTEIN SYNTHESIS INHIBITORS Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{PROTEIN SYNTHESIS INHIBITORS Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{olkimmilo} via \textcolor{DarkBackground}{\uline{cheatography.com/42456/cs/12777/}}}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}olkimmilo \\
  \uline{cheatography.com/olkimmilo} \\
  \end{tabulary}
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\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 11th September, 2017.\\
   Updated 11th September, 2017.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{TETRACYCLINES}}  \tn
% Row 0
\SetRowColor{LightBackground}
Indications \{\{nobreak\}\} & Rickettsial infections (rocky mountain spotted fever), chlamydia, lyme disease, mycoplasmal infections, chronic severe acne, cholera, gastric/duodenal ulcer caused by H. pylori \tn 
% Row Count 8 (+ 8)
% Row 1
\SetRowColor{white}
PK & Excreted in bile, urine, breast milk, undergo enterohepatic circulation \tn 
% Row Count 11 (+ 3)
% Row 2
\SetRowColor{LightBackground}
GI & GI, deposition of drug in bones and teeth, liver failure, phototoxicity, vertigo, avoid in pregnant \tn 
% Row Count 15 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.14 cm} x{2.736 cm} x{3.724 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{TETRACYCLINES}}  \tn
% Row 0
\SetRowColor{LightBackground}
SHORT & \seqsplit{CHLORTETRACYCLINE} \{\{nobreak\}\} &  \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & TETRACYCLINE &  \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & \seqsplit{OXYTETRACYCLINE} \{\{nobreak\}\} &  \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
\seqsplit{INTERMEDIATE} & \seqsplit{DEMECLOCYCLINE} \{\{nobreak\}\} & treats SIADH \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & METHACYCLINE &  \tn 
% Row Count 9 (+ 1)
% Row 5
\SetRowColor{white}
LONG & DOXYCYCLINE & treat infections in pts with anuria (eliminates via bile, feces) \tn 
% Row Count 13 (+ 4)
% Row 6
\SetRowColor{LightBackground}
 & MINOCYCLINE & achieves high CNS concentrations in the absence of inflammation, metabolized in liver \tn 
% Row Count 18 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.12 cm} x{4.88 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{MACROLIDES/KETOLIDES}}  \tn
% Row 0
\SetRowColor{LightBackground}
AZITHROMYCIN \{\{nobreak\}\} & show cross-resistance with erythromycin \{\{nl\}\} longest t1/2 \{\{nl\}\} \{\{nl\}\} {\bf{Advantages:}} less GI disturbances \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
CLARITHROMYCIN \{\{nobreak\}\} & show cross-resistance with erythromycin \{\{nl\}\} \{\{nl\}\} {\bf{Advantage:}} lower incidence of GI disturbances, less frequent dosing \tn 
% Row Count 11 (+ 6)
% Row 2
\SetRowColor{LightBackground}
ERYTHROMYCIN & MOA: Interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the 50S rRNA complex to the P site of the rRNA complex \{\{nl\}\} \{\{nl\}\} Destroyed by gastric acid and must be {\bf{enteric coated}} \{\{nl\}\} shortest t1/2 \tn 
% Row Count 22 (+ 11)
% Row 3
\SetRowColor{white}
TELITHROMYCIN & Effective against macrolide-resistant organisms \{\{nl\}\} \{\{nl\}\} {\bf{Indications:}} respiratory tract infections, including community-acquired bacteria pneumonia, acute exacerbations of chronic bronchitis, sinusitis and strepto pharyngitis \tn 
% Row Count 32 (+ 10)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Indications:}} community acquired pneumonia (mycoplasma, legionella, chlamydia), pertussis, campylobacter jejuni gastroenteritis, MAC (azalides) \newline  \newline {\bf{PK:}} Well distributed, CNS penetration limited except with inflammation. \newline Most of drug is concentrated in the liver and excreted in the bile, some inactivated in the liver by demethylation. \newline  \newline {\bf{AE:}} GI, jaundice, ototoxicity \newline  \newline Bacteriostatic, bactericidal at high doses}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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% Row 0
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CLINDAMYCIN & {\bf{Indications:}} pencillin-resistant anaerobic infections \{\{nl\}\} {\bf{Clinical use:}} SSTI \{\{nl\}\} {\bf{Pharmacology:}} high bone concentrations \{\{nl\}\} {\bf{Toxicity:}} diarrhea, allergy, skin rashes, pseudomembranous colitis caused by overgrowth of C. diff \tn 
% Row Count 11 (+ 11)
% Row 1
\SetRowColor{white}
CHLORAMPHENICOL \{\{nobreak\}\} & {\bf{Indications:}} Rickettsiae (typhus and Rocky Mountain spotted fever); bacterial meningitis \{\{nl\}\} {\bf{Clinical use:}} eye infections \{\{nl\}\} {\bf{AE:}} GI disturbances, gray baby syndrome, aplastic anemia \{\{nl\}\} {\bf{PEARL:}} Because of its toxicity and resistance, its use is restricted to life-threatening infections for which no alternative exists \tn 
% Row Count 26 (+ 15)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{STREPTOGRAMINS}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{QUINUPRISTIN-DALFOPRISTIN} & {\bf{AE:}} venous irritation, athralgia and myalgia, hyperbilirubinemia \tn 
% Row Count 3 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.6 cm} x{6.4 cm} }
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{OXAZOLIDINONES}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{LINEZOLIDE} & {\bf{PK:}} completely absorbed, widely distributed throughout the body, excreted renally and non-renally \{\{nl\}\} {\bf{AE:}} GI upset \tn 
% Row Count 4 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.04 cm} x{4.96 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{AMINOGLYCOSIDES}}  \tn
% Row 0
\SetRowColor{LightBackground}
STREPTOMYCIN \{\{nobreak\}\} & 2\textasciicircum{}nd\textasciicircum{} line agent for the treatment of tuberculosis in combination with other agents to prevent emergence of resistance \{\{nl\}\} {\bf{AE:}} vestibular disturbances \tn 
% Row Count 7 (+ 7)
% Row 1
\SetRowColor{white}
GENTAMICIN & Intrathecal \{\{nl\}\} {\bf{Indications:}} mainly used in combo for severe infections (sepsis and pneumonia) caused by resistant strains of gram negative bacteria, infected burns/woulds/lesions, prevention of catheter infections \tn 
% Row Count 17 (+ 10)
% Row 2
\SetRowColor{LightBackground}
GENT+B-LACTAM & Synergistic effect against pseudomonas, proteus, enterobacter, klebsiella, serratia, stenotrophomonas, and other gram negative rods that are resistant to multiple antibiotics \tn 
% Row Count 25 (+ 8)
% Row 3
\SetRowColor{white}
TOBRAMYCIN & Inhalation \{\{nl\}\} Cautioned in pts with preexisting renal, vestibular or hearing disorders \tn 
% Row Count 29 (+ 4)
% Row 4
\SetRowColor{LightBackground}
STREPTO+PCN \{\{nobreak\}\} & Used for tuleremia and enterococcal carditis \tn 
% Row Count 31 (+ 2)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{8.4cm}{x{3.04 cm} x{4.96 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{AMINOGLYCOSIDES (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
KANAMYCIN (topical only) & Kanamycin-resistant strains may be cross-resistant to amikacin \{\{nl\}\} \tn 
% Row Count 3 (+ 3)
% Row 6
\SetRowColor{white}
AMIKACIN & Semisynthetic derivative of kanamycin, less toxic \{\{nl\}\} {\bf{Indications:}} tx microorganisms resistant to gentamicin and tobramycin \tn 
% Row Count 9 (+ 6)
% Row 7
\SetRowColor{LightBackground}
NEOMYCIN (topical only) & {\bf{Indications:}} reduce the risk of infections during bowel surgery \tn 
% Row Count 12 (+ 3)
% Row 8
\SetRowColor{white}
SPECTINOMYCIN & {\bf{Indications:}} alternative treatment for drug-resistant gonorrhea or gonorrhea in pcn-allergic pts \{\{nl\}\} No cross-resistance with other drugs used in gonorrhea \{\{nl\}\} {\bf{AE:}} pain at injection site, fever, nausea \tn 
% Row Count 21 (+ 9)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{AE:}} {\bf{Ototoxicity}} (reversible), {\bf{nephrotoxicity}} (reversible), neuromuscular blockade \newline  \newline {\bf{PK:}} Levels in most tissue are low.  No CNS penetration.  High accumulation in renal cortex and lymph of inner ear. Excreted into the urine by glomerular filtration.  Accumulation occurs in patients with renal failure, not metabolized \newline  \newline Used against aerobic gram negative bacilli \newline Exhibit concentration-dependent killing \newline Postantibiotic effect}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}