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% Document Info
\author{olkimmilo}
\pdfinfo{
  /Title (other-b-lactams.pdf)
  /Creator (Cheatography)
  /Author (olkimmilo)
  /Subject (OTHER B LACTAMS Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{OTHER B LACTAMS Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{olkimmilo} via \textcolor{DarkBackground}{\uline{cheatography.com/42456/cs/12779/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}olkimmilo \\
  \uline{cheatography.com/olkimmilo} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 11th September, 2017.\\
   Updated 11th September, 2017.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

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% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{CEPHALOSPORINS}}  \tn
% Row 0
\SetRowColor{LightBackground}
Indications \{\{nobreak\}\} & Respiratory, UTI, skin/bone infections, septicemia, gonorrhea, bacterial meningitis \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
AE & Hypersensitivity, NVD, pain at IM injection site \tn 
% Row Count 6 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.44 cm} x{6.56 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{1st GENERATION CEPHALOSPORINS}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{CEPHALEXIN} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\seqsplit{CEFAZOLIN} & Only 1st gen parenteral still used \{\{nl\}\} Long T$\frac{1}{2}$ \{\{nl\}\}Surgical prophylaxis, UTI, SSTI \tn 
% Row Count 4 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Act as penicillin G substitutes and have activity against Proteus mirabilis, E. coli, and Klebsiella pneumoniae (PEcK)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{2ND GENENRATION CEPHALOSPORINS}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{CEFUROXIME} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{CEFOXITIN} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
CEFOTETAN & AE: hypoprothrominemia, disulfiram-like rxns with ethanol \tn 
% Row Count 5 (+ 3)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{CEFONICID} \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
CEFAMANDOLE \{\{nobreak\}\} & AE: hypoprothrominemia, disulfiram-like rxns with ethanol \tn 
% Row Count 9 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Indication:}} community-acquired infections of the respiratory tract (H. influenzae, Moraxella catarrhalis, S. pneumoniae) and UTI (Escherichia coli)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{3RD GENERATION CEPHALOSPORINI}}  \tn
% Row 0
\SetRowColor{LightBackground}
CEFIXIME & Useful activity against B. fragilis \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
CEFDINIR & Useful activity against B. fragilis \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{CEFTAZIDIME} \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{CEFOXATIME} \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
CEFTRIAXONE \{\{nobreak\}\} & Penetrate CNS and used to treat meningitis caused by gram-negative rods except L. monocytogenes \{\{nl\}\} \{\{nl\}\}{\bf{Indication:}} Useful activity genital, anal, and pharyngeal penicillin-resistant N. gonorrhoeae \tn 
% Row Count 15 (+ 9)
% Row 5
\SetRowColor{white}
CEFOTAXIME & Penetrate CNS and used to treat meningitis caused by gram-negative rods except L. monocytogenes \tn 
% Row Count 19 (+ 4)
% Row 6
\SetRowColor{LightBackground}
CEFOPERAZONE\{\{nobreak\}\} & AE: hypoprothrominemia, disulfiram-like rxns with ethanol \tn 
% Row Count 22 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Indications:}} Hospital-acquired gram-negative bacteremia}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.52 cm} x{6.48 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{4TH GENERATION CEPHALOSPORIN}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{CEFIPIME} & Only one in the US, penetrates CNS \tn 
% Row Count 2 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.84 cm} x{6.16 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{5TH GENERATION CEPHALOSPORIN}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{CEFTAROLINE} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\seqsplit{CEFTOBIPROLE} & metabolized in plasma, majority excreted in urine \tn 
% Row Count 3 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.36 cm} x{4.64 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{CARBAPENEMS}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{DORIPENEM} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\seqsplit{IMIPINEM-CILASTIN} \{\{nobreak\}\} & Inactivated by dehydropeptidases in renal tubes \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
MEROPENEM & Greater activity against gram  negative aerobes and less activity against gram positives compared to imipenem \tn 
% Row Count 9 (+ 5)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{ERTAPENEM} \tn 
% Row Count 10 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Indications :}} infections resistant to other drugs, enterbacter infections, extended spectrum B lactam producing gram negatives \newline  \newline {\bf{PK:}} penetrates CNS, cleared by kidney}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.44 cm} x{6.56 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{MONOBACTAMS}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{AZTREONAM} & {\bf{Indications:}} pts allergic to penicillins and/or cephalosporins to treat pneumonia, meningitis, and sepsis, penetrates CNS \tn 
% Row Count 4 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{No activity against gram-positive organisms}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.76 cm} x{6.24 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{BACITRACIN (topical)}}  \tn
% Row 0
\SetRowColor{LightBackground}
MOA & Inhibits cell wall formation by interference with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule that carries the building-blocks of the peptidoglycan bacterial cell wall \tn 
% Row Count 7 (+ 7)
% Row 1
\SetRowColor{white}
\seqsplit{Indications} & Highly nephrotoxic when administered systemically and is thus used topically for gram positive cocci and bacilli skin infections \tn 
% Row Count 12 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{CYCLOSERINE}}  \tn
% Row 0
\SetRowColor{LightBackground}
MOA & Structural analog of D-alanine and inhibits the incorporation of D-alanine into peptidoglycan pentapeptide chain \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
Indications \{\{nobreak\}\} & Treats tuberculosis \tn 
% Row Count 7 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Toxicity & Serious dose-related CNS toxicity \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{GLYCOPEPTIDES}}  \tn
% Row 0
\SetRowColor{LightBackground}
VANCOMYCIN & Resistance in enterococci develops due to modification in binding site (D-ala-D-ala  D-lactate) and increased numbers of D-ala-D-ala residues (S. aureus) \{\{nl\}\} \{\{nl\}\} Effective against gram positive producing lactamases and those resistant to nafcillin and methacillin (MRSA, MRSE) or allergic to penicillin or cephalosporin \{\{nl\}\} \{\{nl\}\} {\bf{Indications:}} infections caused by MRSA (sepsis, endocarditis), \seqsplit{penicillin-resistant} enterococci, individuals with prosthetic heart valve, oral administration of antibiotic induced colitis due to C. diff \{\{nl\}\} \{\{nl\}\} SE: fever, chills, phlebitis \tn 
% Row Count 30 (+ 30)
% Row 1
\SetRowColor{white}
VANCO + GENT & Use: enterococcal endocarditis (penicillin allergy) \tn 
% Row Count 33 (+ 3)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{GLYCOPEPTIDES (cont)}}  \tn
% Row 2
\SetRowColor{LightBackground}
VANCO + CEFTRIAXONE \{\{nobreak\}\} \{\{nl\}\} VANCO + CEFOTAXIME \{\{nobreak\}\} \{\{nl\}\} VANCO + RIFAMPIN \{\{nobreak\}\} & Use: meningitis \seqsplit{(penicillin-resistant} strain of pneuomococcus \tn 
% Row Count 6 (+ 6)
% Row 3
\SetRowColor{white}
TELAVANCIN & Two mechanisms of action; first is the same as vancomycin and the second is it disrupts the bacterial cell membrane potential and increases membrane permeability \{\{nl\}\} \{\{nl\}\} t1/2 is 8 hours allowing for daily dosing \{\{nl\}\} \{\{nl\}\} Teratogenic \tn 
% Row Count 19 (+ 13)
% Row 4
\SetRowColor{LightBackground}
DAPTOMYCIN & Long half life of 6-11 days allows for weekly dosing \{\{nl\}\} \seqsplit{Methicillin-susceptible} and \seqsplit{methicillin-resistant} Streptococcus pneumoniae, Streptococcus pyogenes, Corynebacterium jeikeium, E. faecalis and E. faecium (including VRE) \{\{nl\}\} \{\{nl\}\} {\bf{Indications:}} skin infections and bacteremia caused by S. aureus \{\{nl\}\} \{\{nl\}\} {\bf{AE:}} constipation, nausea, HA, insomnia \tn 
% Row Count 38 (+ 19)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{GLYCOPEPTIDES (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
FOSFOMYCIN & MOA: inhibits UDP-N acetylglucosamine 3-Enolpyruvte transferase \{\{nl\}\} \{\{nl\}\} Indications: UTI \tn 
% Row Count 5 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}