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% Document Info
\author{olkimmilo}
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  /Title (antimetabolites-nucleic-acid-synthesis-inhibitors.pdf)
  /Creator (Cheatography)
  /Author (olkimmilo)
  /Subject (Antimetabolites, Nucleic acid Synthesis Inhibitors Cheat Sheet)
}

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    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Antimetabolites, Nucleic acid Synthesis Inhibitors Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{olkimmilo} via \textcolor{DarkBackground}{\uline{cheatography.com/42456/cs/12781/}}}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}olkimmilo \\
  \uline{cheatography.com/olkimmilo} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 11th September, 2017.\\
   Updated 11th September, 2017.\\
   Page {\thepage} of \pageref{LastPage}.
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  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{p{1.04 cm} x{6.96 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{SULFONAMIDES}}  \tn
% Row 0
\SetRowColor{LightBackground}
MOA & Mammalian cells lack dihydropteroate synthase and require exogenous sources of folate. Inhibiting synthesis of folic acid (folate), a compound required by all cells to make DNA, RNA, and proteins \tn 
% Row Count 6 (+ 6)
% Row 1
\SetRowColor{white}
PK & Absorbed from the stomach and small intestines, widely distributed to tissues and body fluids (CNS, CSF, placenta, fetus) \{\{nl\}\} Excreted unchanged into the urine. \{\{nl\}\} Eliminated by glomerular filtration and breast milk. \tn 
% Row Count 13 (+ 7)
% Row 2
\SetRowColor{LightBackground}
AE & Crystalluria, hypersensitivity, hematopoietic disturbances (hemolytic anemia), kernicterus \tn 
% Row Count 16 (+ 3)
% Row 3
\SetRowColor{white}
\seqsplit{CONTRA} & Pregnant women, children \textless{}2 mo old \tn 
% Row Count 18 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{p{0.76 cm} x{2.28 cm} x{4.56 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{SULFONAMIDES}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{{\bf{ORAL, NONABSORB}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
 & \seqsplit{SULFASALAZINE} &  \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{{\bf{ORAL, ABSORBABLE}}} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
SHORT & SULFACYTINE &  \tn 
% Row Count 6 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & \seqsplit{SULFISOXAZOLE} & {\bf{Indications:}} UTI \tn 
% Row Count 8 (+ 2)
% Row 5
\SetRowColor{white}
 & \seqsplit{FULFAMETHIZOLE} &  \tn 
% Row Count 10 (+ 2)
% Row 6
\SetRowColor{LightBackground}
\seqsplit{INTERM} & \seqsplit{SULFADIAZINE} & {\bf{Indications:}} 1st line for acute toxoplasmosis \tn 
% Row Count 13 (+ 3)
% Row 7
\SetRowColor{white}
 & \seqsplit{SULFAMETHOXAZOLE} & {\bf{Indications:}} UTI \tn 
% Row Count 15 (+ 2)
% Row 8
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 & \seqsplit{SULFAPYRIDINE} &  \tn 
% Row Count 17 (+ 2)
% Row 9
\SetRowColor{white}
LONG & SULFADOXINE & {\bf{Indication:}} 2nd line for malaria \{\{nl\}\} \tn 
% Row Count 19 (+ 2)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{{\bf{TOPICAL}}} \tn 
% Row Count 20 (+ 1)
% Row 11
\SetRowColor{white}
 & SODIUM \seqsplit{SULFACETAMIDE} &  \tn 
% Row Count 22 (+ 2)
% Row 12
\SetRowColor{LightBackground}
 & MAFENIDE ACETATE &  \tn 
% Row Count 24 (+ 2)
% Row 13
\SetRowColor{white}
 & SILVER \seqsplit{SULFADIAZINE} &  \tn 
% Row Count 26 (+ 2)
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\mymulticolumn{3}{x{8.4cm}}{{\bf{Sulfadiazine}} and {\bf{sulfadoxone}} are used in combo with pyrimethamine}  \tn 
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{DHFR INHIBITORS}}  \tn
% Row 0
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TMP/SMX & Drug of choice for infections such as Pneumocystis jiroveci pneumonia, toxoplasmosis, nocardiosis, and occasionally other bacterial infections \tn 
% Row Count 6 (+ 6)
% Row 1
\SetRowColor{white}
TRIMETHOPRIM & UTI \tn 
% Row Count 7 (+ 1)
% Row 2
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PYRIMETHAMINE \{\{nobreak\}\} & Parasitic \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\mymulticolumn{2}{x{8.4cm}}{{\bf{AE:}} megaloblastic anemia, leukopenia, granulocytopenia}  \tn 
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\begin{tabularx}{8.4cm}{x{2.96 cm} x{5.04 cm} }
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{FLUOROQUINOLONES}}  \tn
% Row 0
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MOA & Inhibit one or both of the 2 prokaryotic type II topoisomerases \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
PK & Well absorbed, widely distributed in body fluids and tissues\{\{nl\}\} Excreted really \tn 
% Row Count 7 (+ 4)
% Row 2
\SetRowColor{LightBackground}
INDICATIONS \{\{nobreak\}\} & Resistant respiratory infections, anthrax, gonorrhea, UTI and bacterial diarrhea caused by shigella, salmonella, toxigenic E coli, and campylobacter \tn 
% Row Count 13 (+ 6)
% Row 3
\SetRowColor{white}
AE & NVD, HA, dizziness, phototoxic, connective tissue problems \tn 
% Row Count 16 (+ 3)
% Row 4
\SetRowColor{LightBackground}
BBW & Tendinitis, tendon rupture \tn 
% Row Count 18 (+ 2)
% Row 5
\SetRowColor{white}
CONTRA & Avoid in pregos, nursing mothers, and children \textless{}18 \tn 
% Row Count 20 (+ 2)
% Row 6
\SetRowColor{LightBackground}
DDI & THEOPHYLLINE, WARFARIN, CYCLOSPORINE \tn 
% Row Count 22 (+ 2)
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\mymulticolumn{2}{x{8.4cm}}{Concentration-dependent killing}  \tn 
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\begin{tabularx}{8.4cm}{x{3.04 cm} x{4.96 cm} }
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{FLUOROQUINOLONES}}  \tn
% Row 0
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\mymulticolumn{2}{x{8.4cm}}{NALIDIXIC ACID} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{NORFLOXACIN} \tn 
% Row Count 2 (+ 1)
% Row 2
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\mymulticolumn{2}{x{8.4cm}}{OFLOXACIN} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
CIPROFLOXACIN \{\{nobreak\}\} & No longer recommended for gonococcal in the US \{\{nl\}\} {\bf{Indications:}} chlamydial urethritis, cervicitis \tn 
% Row Count 8 (+ 5)
% Row 4
\SetRowColor{LightBackground}
LEVOFLOXACIN & No longer recommended for gonococcal in the US \{\{nl\}\} {\bf{Indications:}} chlamydial urethritis, cervicitis \{\{nl\}\}QD, long t1/2 \tn 
% Row Count 14 (+ 6)
% Row 5
\SetRowColor{white}
MOXIFLOXACIN & Only one not effective in UTI's \{\{nl\}\}QD, long t1/2 \{\{nl\}\} {\bf{Contra:}} puts predisposed to arrhythmias or pts that are taking anti arrhythmic meds due to QT prolongation \tn 
% Row Count 22 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.84 cm} x{6.16 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{METHENAMINE}}  \tn
% Row 0
\SetRowColor{LightBackground}
MOA & Metabolized to formaldehyde and ammonia in acidic pH. The formaldehyde is lethal to bacteria. \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
\seqsplit{INDICATION} & Urinary tract \seqsplit{antiseptics/antimicrobials} \tn 
% Row Count 6 (+ 2)
% Row 2
\SetRowColor{LightBackground}
SIDE EFFECTS & GI distress, may cause albuminuria, hematuria, and rashes at higher doses \tn 
% Row Count 9 (+ 3)
% Row 3
\SetRowColor{white}
CONTRA & Pts with renal insufficiency \tn 
% Row Count 10 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}