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% Packages
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\usepackage{multicol}           % Allows multicols in tables
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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
%\usepackage[english,german,french,spanish,italian]{babel}              % Languages

% Document Info
\author{olkimmilo}
\pdfinfo{
  /Title (acetaminophen-overdose.pdf)
  /Creator (Cheatography)
  /Author (olkimmilo)
  /Subject (Acetaminophen Overdose Cheat Sheet)
}

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% This two commands together give roughly
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% Commands
\newcommand{\SetRowColor}[1]{\noalign{\gdef\RowColorName{#1}}\rowcolor{\RowColorName}} % Shortcut for row colour
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% Header and Footer
\pagestyle{fancy}
\fancyhead{} % Set header to blank
\fancyfoot{} % Set footer to blank
\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
    }
\end{tabulary}
\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Acetaminophen Overdose Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{olkimmilo} via \textcolor{DarkBackground}{\uline{cheatography.com/42456/cs/17033/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}olkimmilo \\
  \uline{cheatography.com/olkimmilo} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 12th September, 2018.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{3.76 cm} x{4.24 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{4 Phases of APAP Toxicity}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Phase 1\{\{nl\}\} (1-24 hrs)}}\{\{ac\}\} & - Commonly asymptomatic or\{\{nl\}\}- Non-specific (N/V) \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Phase 2\{\{nl\}\} (24-48 hrs)}}\{\{ac\}\} & - Labs show hepatotoxicity \{\{nl\}\}~~~~~- Increase INR\{\{nl\}\}~~~~~- Increase AST/ALT\{\{nl\}\}- Phase 1 symptoms subside \tn 
% Row Count 11 (+ 8)
% Row 2
\SetRowColor{LightBackground}
{\bf{Phase 3\{\{nl\}\} (48-96 hrs)}}\{\{ac\}\} & - Fulminant liver failure\{\{nl\}\}~~~~ - Jaundice\{\{nl\}\}~~~~~- Encephalopathy\{\{nl\}\}~~~~~- Coagulopathy\{\{nl\}\}~~~~~- hepa-to-renal syndrome \tn 
% Row Count 22 (+ 11)
% Row 3
\SetRowColor{white}
{\bf{Phase 4\{\{nl\}\} (\textgreater{}96 hrs)}}\{\{ac\}\} & - Pt either\{\{nl\}\}~~~~~- Recovers\{\{nl\}\}~~~~~- Dies\{\{nl\}\}~~~~~- Receives liver transplant \tn 
% Row Count 30 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{APAP Explanation of Chart on Pg 270}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{NAPQI}}\{\{nl\}\}\{\{ac\}\}N-acetyl-p-benzoquinone-imine & APAP undergoes CYP2E1 (only with excessive doses) and produces NAPQI (toxic) \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
{\bf{Antidote}}\{\{ac\}\} & NAC (N-acetylcysteine) \tn 
% Row Count 6 (+ 2)
% Row 2
\SetRowColor{LightBackground}
{\bf{NAC}}\{\{ac\}\} & ↑ glutathione = ↑ GSH \seqsplit{(glutathione-S-traferase)} \tn 
% Row Count 9 (+ 3)
% Row 3
\SetRowColor{white}
{\bf{GSH}}\{\{ac\}\} & Converts NAPQI to {\bf{mercapturic acid}} (excretes safely from the body) \tn 
% Row Count 13 (+ 4)
% Row 4
\SetRowColor{LightBackground}
{\bf{Rumack Matthew Nomogram}}\{\{ac\}\} & APAP blood levels are drawn and plotted on this \tn 
% Row Count 16 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.08 cm} x{5.92 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{APAP Toxicity Tx}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{N-Acetylcysteine}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
{\bf{Oral}}\{\{ac\}\} & - 140 mg/kg x 1 followed by \{\{nl\}\} - 70 mg/kg Q4H x 17 doses\{\{nl\}\}- Repeat dose if emesis occurs within 1 hr of administration \tn 
% Row Count 6 (+ 5)
% Row 2
\SetRowColor{LightBackground}
{\bf{IV}}\{\{ac\}\} & - 150 mg/kg IV x 60 mins followed by\{\{nl\}\}\{\{nobreak\}\} - 50 mg/kg IV x 4 hrs followed by\{\{nl\}\} - 100 mg/kg IV x 16 hrs \tn 
% Row Count 11 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Opioid Overdose Symptoms}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Slowed breathing (respiratory depression)} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Pinpoint pupils} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{-  Altered mental status} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Unconsciousness (sedation)} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- When in doubt give {\bf{naloxone}}}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.8 cm} x{5.2 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Opioid Toxicity Tx}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Naloxone}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
{\bf{How it works}}\{\{ac\}\} & - If administered quickly, naloxone reverses depressant effects of opioids \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
{\bf{Naloxone AE:}}\{\{ac\}\} & - Little to none if no opioids were ingested \tn 
% Row Count 6 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}