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% Document Info
\author{Eeveepuff (NKeeveepuff)}
\pdfinfo{
  /Title (oncology-part-2.pdf)
  /Creator (Cheatography)
  /Author (Eeveepuff (NKeeveepuff))
  /Subject (Oncology Part 2 Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Oncology Part 2 Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Eeveepuff (NKeeveepuff)} via \textcolor{DarkBackground}{\uline{cheatography.com/149511/cs/32569/}}}
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\noindent
\begin{multicols}{3}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Eeveepuff (NKeeveepuff) \\
  \uline{cheatography.com/nkeeveepuff} \\
  \end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 19th June, 2022.\\
   Updated 19th June, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Tumor Lysis Syndrome}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Definition} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Simultaneous death of many cancer cells produces release to blood of enormous quantities of products of their destruction.} \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{When?} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}May particularly occur during initial phase of treatment of pts. w/ large chemosensitive tumors} \tn 
% Row Count 8 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Symptoms} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Hyperphosphatemia \{\{nl\}\} Hyperuricemia \{\{nl\}\} Hyperkalemia (life-threatening: cardiac arrhytmias) \{\{nl\}\} Hypocalcemia secondary to formation of calcium phosphate: tetany, mental agitation, seizures \{\{nl\}\} Acute renal failure} \tn 
% Row Count 14 (+ 6)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Diagnosis} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Based on development of \{\{nl\}\} -increased lvl. of serum uric acid (8mg\%) ,  phosphate (4,5 mg\%) , and potassium (6mg\%) \{\{nl\}\} -decreased levels of serum calcium (7mg\%) \{\{nl\}\} -increased serum creatinine (1,5 x upper normal limit) \{\{nl\}\} -cardiac arrhythmias or death, seizures} \tn 
% Row Count 21 (+ 7)
% Row 4
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\mymulticolumn{1}{x{5.377cm}}{Management:} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}• Forced diuresis 3 L/m\textasciicircum{}2\textasciicircum{} PWE + furosemide \{\{nl\}\}• Allopurinol to fight hyperuricemia (protein degradation). \{\{nl\}\}• Novel agent: rasburicase} \tn 
% Row Count 26 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Hypercalcemia - Clinical Symptoms}}  \tn
% Row 0
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Pts. w/ Ca. conc. b/w 10.5 \& 12 mg/dl usually asymptomatic & Clinical manifestations appear w/ higher lvls. \tn 
% Row Count 3 (+ 3)
% Row 1
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Renal & polyuria \{\{nl\}\} nephrolithiasis (chronic HC) \tn 
% Row Count 6 (+ 3)
% Row 2
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GI & anorexia \{\{nl\}\} nausea \{\{nl\}\} vomiting \{\{nl\}\} constipation \{\{nl\}\} pancreatitis \tn 
% Row Count 10 (+ 4)
% Row 3
\SetRowColor{white}
Neuro-psych & weakness \{\{nl\}\} fatigue \{\{nl\}\} confusion \{\{nl\}\} stupor \{\{nl\}\} coma \tn 
% Row Count 14 (+ 4)
% Row 4
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CV & shortened QT interval on ECG \{\{nl\}\} bradyarrhythmias \{\{nl\}\} heart block \{\{nl\}\} cardiac arrest \tn 
% Row Count 19 (+ 5)
% Row 5
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Ocular & band keratopathy (chronic HC) \tn 
% Row Count 21 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Local Radiotherapy}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{Teleradiotherapy} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}tumor irradiated from a distant (usually \textasciitilde{} 1m) source} \tn 
% Row Count 3 (+ 3)
% Row 1
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\mymulticolumn{1}{x{5.377cm}}{Brachytherapy} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}irradiation source is placed @ direct vicinity of irradiated tissue \{\{nl\}\} (aka. Curietherapy)} \tn 
% Row Count 6 (+ 3)
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\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Brachytherapy}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{Contact or intracavital irradiation} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Installation of radiation source into cavity or through a natural route} \tn 
% Row Count 3 (+ 3)
% Row 1
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\mymulticolumn{1}{x{5.377cm}}{Interstitial irradiation} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Insertion of the radioactive source interstitially} \tn 
% Row Count 6 (+ 3)
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\mymulticolumn{1}{x{5.377cm}}{LDR (low-dose-rate)} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Currently, most freq. = Cesium 137 \{\{nl\}\} -{}-\textgreater{} dose rate: 1 cGy/min \{\{nl\}\} Intracavital: most freq. cervical ca. \{\{nl\}\} Interstitial: oral cavity ca. , pharyngeal ca. , prostate ca. , sarcoma} \tn 
% Row Count 12 (+ 6)
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\mymulticolumn{1}{x{5.377cm}}{HDR (high-dose-rate)} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Currently, most freq. = Iridiuim 192 \{\{nl\}\} -{}-\textgreater{} dose rate: 100 cGy/min \{\{nl\}\} Intracavital: vaginal ca. , oesophageal ca. , lung ca. , sarcoma \{\{nl\}\} Interstitial: prostate ca.} \tn 
% Row Count 17 (+ 5)
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Teleradiotherapy}}  \tn
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\mymulticolumn{1}{x{5.377cm}}{Conventional} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}orthovolt (125-500 kV) \{\{nl\}\} -can only be used for palliative tx. of superficially located metastases \{\{nl\}\} -{}-\textgreater{} practically not used these days} \tn 
% Row Count 5 (+ 5)
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\mymulticolumn{1}{x{5.377cm}}{Megavolt} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}telecobaltotherapy, photons \& electrons from linear accelerator, neutrons from either neutron generator or cyclotrone \{\{nl\}\} -{}-\textgreater{} energy: 4 - 20 MeV} \tn 
% Row Count 10 (+ 5)
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\begin{tabularx}{5.377cm}{x{2.09034 cm} x{2.88666 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Renal Ca. - Clinical Presentation}}  \tn
% Row 0
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Typical Triad \{\{fa-triangle\}\} & {\bf{hematuria \{\{nl\}\} abd. pain \{\{nl\}\} flank / abd. mass}} {\emph{(palpable tumor)}} \tn 
% Row Count 4 (+ 4)
% Row 1
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Less freq. & fever \{\{nl\}\} weight loss \{\{nl\}\} anemia \{\{nl\}\} varicocele (abn. enlargement of pampiniform venous plexus) \{\{nl\}\} PARANEOPLASTIC SYNDROMES: \{\{nl\}\} -{}-\textgreater{} erythrocytosis\{\{nl\}\}-{}-\textgreater{} hypercalcemia \{\{nl\}\} -{}-\textgreater{} nonmetastatic hepatic dysfunc. (Stauffer's synd.) \{\{nl\}\} -{}-\textgreater{} acquired dysfibrinogenemia \tn 
% Row Count 17 (+ 13)
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\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Pancreatic cancer}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{Notes} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Freq. site = Head of pancreas \{\{nl\}\} No screening test available \{\{nl\}\} 5-year survival \textless{} 5\% \{\{nl\}\} Median age of diag. = 72 y/o \{\{nl\}\} Peak incidence -  65-84 y/o \{\{nl\}\} Males \textgreater{} Females} \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Clinical Features} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Pain \{\{nl\}\}Obstructive Jaundice \{\{nl\}\} Weight loss \{\{nl\}\} Anorexia} \tn 
% Row Count 8 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Risk Factors} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}• Cigarette Smoking, Obesity, Non-hereditary Chronic Pancreatitis \{\{nl\}\} • Environmental Factors (diet, coffee), prev. partial gastrectomy / cholecystectomy \& H. pylori} \tn 
% Row Count 13 (+ 5)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Physical Findings`} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}(+) Courvoisier's sign \{\{nl\}\}• Palpable, nontender gallbladder \{\{nl\}\} (+) Virchow's Node \{\{nl\}\} Advanced Disease \{\{nl\}\} • Abdominal Mass, Hepatomegaly, Splenomegaly, Ascitis} \tn 
% Row Count 18 (+ 5)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Diagnostic Procedures} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Ultrasound \{\{nl\}\} CT Scan \{\{nl\}\} ERCP \{\{nl\}\} Endoscopic US \{\{nl\}\} MRCP \{\{nl\}\} FDG-PET*} \tn 
% Row Count 21 (+ 3)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{CA 19-9 (Serum Marker)} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}• 80-90\% sensitivity \& specificity \{\{nl\}\}• Suggestive of diag. pancreatic ca. \{\{nl\}\} • Prognostic impilcations – Very high levels w/ inoperable disease \{\{nl\}\}• Serial evaluation useful for monitoring response to tx. \{\{nl\}\} • Detecting recurrence in pts. w/ completely resected tumors} \tn 
% Row Count 29 (+ 8)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Treatment} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Symptom management \{\{nl\}\} Endoscopic biliary / duodenal stenting \{\{nl\}\} Intestinal bypass surgery \{\{nl\}\} Deoxycytidine analogue Gemcitabine} \tn 
% Row Count 33 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\mymulticolumn{1}{x{5.377cm}}{*Excluding occult distal metastasis}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
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\begin{tabularx}{5.377cm}{x{2.33919 cm} x{2.63781 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{BI-RADS}}  \tn
% Row 0
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0 (incomplete) & Recommend add. imaging -{}-\textgreater{} mammogram / targeted US \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
1 (negative) & Routine breast MR screening if cumulative lifetime risk ≥ 20\% \tn 
% Row Count 6 (+ 3)
% Row 2
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2 (benign) & Routine breast MR screening if cumulative lifetime risk ≥ 20\% \tn 
% Row Count 9 (+ 3)
% Row 3
\SetRowColor{white}
3 (prob. benign) & Short-interval (6 mth) follow-up \tn 
% Row Count 11 (+ 2)
% Row 4
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4 (suspicious) & Tissue diagnosis \tn 
% Row Count 12 (+ 1)
% Row 5
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5 (highly suggestive of malignancy) & Tissue diagnosis \tn 
% Row Count 14 (+ 2)
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6 (known biopsy-proven malignancy) & Surgical excision when clinically appropriate \tn 
% Row Count 17 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\mymulticolumn{2}{x{5.377cm}}{{\bf{B}}reast {\bf{I}}maging {\bf{R}}eporting and {\bf{D}}atabase {\bf{S}}ystem score.  \newline - Scoring syst. used by radiologists describe mammogram results \newline - Most efficient tool to help detect breast cancer, esp. at its earliest stage \newline  \newline *Table taken from UCSF Department of Radiology \& Biomed. Imaging}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
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% That's all folks
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