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% Document Info
\author{Eeveepuff (NKeeveepuff)}
\pdfinfo{
  /Title (oncology-part-1.pdf)
  /Creator (Cheatography)
  /Author (Eeveepuff (NKeeveepuff))
  /Subject (Oncology Part 1 Cheat Sheet)
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\noindent
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    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Oncology Part 1 Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Eeveepuff (NKeeveepuff)} via \textcolor{DarkBackground}{\uline{cheatography.com/149511/cs/32483/}}}
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\noindent
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Eeveepuff (NKeeveepuff) \\
  \uline{cheatography.com/nkeeveepuff} \\
  \end{tabulary}
\vfill
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 19th June, 2022.\\
   Updated 19th June, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{multicols*}{4}

\begin{tabularx}{3.833cm}{x{1.7165 cm} x{1.7165 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Important Notes}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{Diagnosis = histopathology*} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Nadir & Period when side effect of syst. chemotherapy most severe \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
{\emph{Nadir for most of cytostatic drugs}} & Minimal number of leukocytes after chemotherapy that most often falls b/w 6 \& 14 days \tn 
% Row Count 9 (+ 5)
% Row 3
\SetRowColor{white}
Primary prevention of febrile neutropenia & risk of FN ≥ 20\% \{\{nl\}\} Filgrastim (or) Filigrastin \tn 
% Row Count 12 (+ 3)
% Row 4
\SetRowColor{LightBackground}
Absorbed dose of ionizing radiation & Dose quantity which is the measure of energy deposited in matter by ionizing radiation / unit mass \{\{nl\}\} SI = Gray (Gy) \tn 
% Row Count 18 (+ 6)
% Row 5
\SetRowColor{white}
Monoclonal antibody drugs & Usually end in -mab \tn 
% Row Count 20 (+ 2)
% Row 6
\SetRowColor{LightBackground}
Tyrosine Kinase Inhibitors & Targeted therapy in adenocarcinoma \{\{nl\}\} -{}-\textgreater{} erlotinib, gefitinib, afatinib \tn 
% Row Count 24 (+ 4)
% Row 7
\SetRowColor{white}
WHO Analgesic Ladder & {\bf{3 Steps}} \{\{nl\}\} Step 1: Non-opioid + optional adjuv. analgesics for mild pain \{\{nl\}\} Step 2: Weak opioid + non-opioid \& adjuv. analgesics for mild - moderate pain \{\{nl\}\} Step 3: Strong opioid + non-opioid \& adjuv. analgesics for moderate - severe pain \tn 
% Row Count 37 (+ 13)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{* excluding CLL, CML t(9;22), etc.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{x{1.40753 cm} x{2.02547 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{General Symptoms \& Signs}}  \tn
% Row 0
\SetRowColor{LightBackground}
Unexplained pain & Skin Changes \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Palor (anemia) & Fever of unknown origin \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
Night sweats & Jaundice \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{3.833cm}}{Cachexia or substantial body weight loss in short period of time (10\%)} \tn 
% Row Count 5 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{x{1.06423 cm} x{2.36877 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Blood Tests}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{CBC}} & {\bf{ESR, LDH, CRP}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
{\bf{Urine analysis}} & {\bf{Specific changes in typical blood parameters}} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Tumor markers & FC (flow cytometry) \tn 
% Row Count 5 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{x{1.61351 cm} x{1.81949 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Tumor Markers}}  \tn
% Row 0
\SetRowColor{LightBackground}
CEA (carcinoembryonic antigen) & used in colorectal ca. monitoring \{\{nl\}\} Not specific (lung, prostate, breast ca.) \{\{nl\}\} Elevated in inflammation \tn 
% Row Count 6 (+ 6)
% Row 1
\SetRowColor{white}
AFP \seqsplit{(alpha-fetoprotein)} & conc. \{\{fa-long-arrow-up\}\} in hepatocellular carcinomas \& some testicular ca. (nonseminomas) \tn 
% Row Count 11 (+ 5)
% Row 2
\SetRowColor{LightBackground}
b-HCG (human chorionic gonadotropin) & \{\{fa-long-arrow-up\}\} in gestational trophoblastic neoplasia (eg: chorioncarcinoma), some ca. \& embryonic-type tumors: neuroblastoma \& nephroblastoma \tn 
% Row Count 19 (+ 8)
% Row 3
\SetRowColor{white}
CA125 & In 80\% of ovarian ca. \{\{nl\}\} Assessment of tumor mass \tn 
% Row Count 22 (+ 3)
% Row 4
\SetRowColor{LightBackground}
CA 15-3 & In disseminated breast ca. , not used for monitoring \tn 
% Row Count 25 (+ 3)
% Row 5
\SetRowColor{white}
Thyreoglobulin & In papillary \& follicular thyroid ca. \tn 
% Row Count 27 (+ 2)
% Row 6
\SetRowColor{LightBackground}
Calcitonin & In medullary thyroid ca. \tn 
% Row Count 29 (+ 2)
% Row 7
\SetRowColor{white}
PSA \seqsplit{(prostate-specific} antigen) & Highly specific for prostate \tn 
% Row Count 31 (+ 2)
\end{tabularx}
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\begin{tabularx}{3.833cm}{x{1.61351 cm} x{1.81949 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Tumor Markers (cont)}}  \tn
% Row 8
\SetRowColor{LightBackground}
CA 19-9 & Gastrointestinal tract ca. (not specific) \tn 
% Row Count 2 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
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\begin{tabularx}{3.833cm}{X}
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\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{7 Cancer Warning Signals ({\bf{CAUTION}})}}  \tn
% Row 0
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\mymulticolumn{1}{x{3.833cm}}{{\bf{C}}hange in bowel / bladder habits} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{A}} sore throat that does not heal} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{{\bf{U}}nusual bleeding or discharge} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{T}}hickening of lump in breast or elsewhere} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{{\bf{I}}ndigestion / difficulties in swallowing} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{O}}bvious change in wart or mole} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{{\bf{N}}agging cough or hoarseness} \tn 
% Row Count 7 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{This is by American Cancer Society}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{3.833cm}{x{1.06155 cm} x{1.03122 cm} x{0.94023 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{3.833cm}}{\bf\textcolor{white}{TNM Classification}}  \tn
% Row 0
\SetRowColor{LightBackground}
Tumour (extent) & Nodes (region) & Metastasis (distant) \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
T0 & N0 & M0 \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
T1 & N1 & M1 \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
T2 & N2 &  \tn 
% Row Count 5 (+ 1)
% Row 4
\SetRowColor{LightBackground}
T3 & N3 &  \tn 
% Row Count 6 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{3}{x{3.833cm}}{T4} \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
Tx - can't be assessed & Nx - can't be assessed &  \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{3.833cm}}{cTNM - clinical \newline pTNM - pathological \newline ycTNM - treated tumours \newline  \newline *in pM -{}-\textgreater{} only pM1 possible! \newline  \newline m - multiple primary tumors @ single site {[}eg: T2(m) T1c(5){]} \newline aTNM - @ autopsy \newline rTNM - @ recurrence \newline  \newline V Venous invasion \newline L Lymphatic invasion \newline Pn - {\bf{P}}eri{\bf{n}}eural invasion}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
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\begin{tabularx}{3.833cm}{x{1.40753 cm} x{2.02547 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Oncogene + Antioncogene}}  \tn
% Row 0
\SetRowColor{LightBackground}
BRCA-1 \& BRCA-2 & Breast ca. , ovarian ca. \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
MGMT & Glioblastoma \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
PALB-2 & Breast ca. , ovarian ca. , pancreatic ca. \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
RAS & lung ca. , ovarian ca. , colon ca. , etc. \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
EGFR & lung ca. , glioblastoma, breast invasive ductal ca. , colon ca. \tn 
% Row Count 10 (+ 3)
% Row 5
\SetRowColor{white}
p-53 & Li-Fraumeni syndrome \{\{nl\}\} breast ca. soft tissue sarcoma, osteosarcoma, brain tumors, pancreatic ca. , adrenal gland ca. , gastric ca. , colorectal ca. \tn 
% Row Count 17 (+ 7)
% Row 6
\SetRowColor{LightBackground}
DCC (deleted colorectal ca.) & cause spectrum of neurological disorders \tn 
% Row Count 19 (+ 2)
% Row 7
\SetRowColor{white}
ATM & Ataxia-Telangiesctasia (AT) \{\{nl\}\} breast ca. risk, pancreatic ca. risk. ovarian ca. risk. prostate ca. , melanoma, etc. \tn 
% Row Count 25 (+ 6)
% Row 8
\SetRowColor{LightBackground}
Rb & retinoblastoma, bladder ca. , small cell lung ca. \tn 
% Row Count 28 (+ 3)
% Row 9
\SetRowColor{white}
C-SIS & gliomas \tn 
% Row Count 29 (+ 1)
% Row 10
\SetRowColor{LightBackground}
C-ERB-B & glioblastoma, breast ca. \tn 
% Row Count 31 (+ 2)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{3.833cm}{x{1.40753 cm} x{2.02547 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Oncogene + Antioncogene (cont)}}  \tn
% Row 11
\SetRowColor{LightBackground}
C-ABL & chronic myeloid leukemia \tn 
% Row Count 2 (+ 2)
% Row 12
\SetRowColor{white}
C-MYC & leukemias, breast ca. , etc. \tn 
% Row Count 4 (+ 2)
% Row 13
\SetRowColor{LightBackground}
C-BCL-2 & chronic lymphocytic leukemia, malignant melanoma \tn 
% Row Count 7 (+ 3)
% Row 14
\SetRowColor{white}
NK-1 & neurofibroma, pheochromocytoma, leukemia \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{p{0.3433 cm} x{3.0897 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Assessment Scale - ECOG}}  \tn
% Row 0
\SetRowColor{LightBackground}
0 & Fully active, able to carry on all pre-disease performance w/o restriction \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
1 & Restricted in physically strenuous activity b/ ambulatory \& able to carry out work of a light or sedentary nature \{\{nl\}\} eg: light house work, office work \tn 
% Row Count 8 (+ 5)
% Row 2
\SetRowColor{LightBackground}
2 & Ambulatory \& capable of all selfcare b/ unable to carry out any work activities. Up and about \textgreater{}50\% of waking hours \tn 
% Row Count 12 (+ 4)
% Row 3
\SetRowColor{white}
3 & Capable of only limited selfcare, confined to bed or chair \textgreater{}50\% of waking hours \tn 
% Row Count 15 (+ 3)
% Row 4
\SetRowColor{LightBackground}
4 & Completely disabled. Can't carry on any selfcare. Totally confined to bed or chair \tn 
% Row Count 18 (+ 3)
% Row 5
\SetRowColor{white}
5 & Dead \tn 
% Row Count 19 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
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\begin{tabularx}{3.833cm}{p{0.3433 cm} x{3.0897 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Karnofsky PSS Definitions Rating (\%) Criteria}}  \tn
% Row 0
\SetRowColor{LightBackground}
100 & Normal no complaints ; no evidence of disease \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
90 & Able to carry on normal activity ; minor signs or symp. of disease \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
80 & Normal activity with effort ; some signs or symp. of disease \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
70 & Cares for self ; unable to carry on normal activity or to do active work \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
60 & Requires occasional assistance, b/ is able to care for most of his personal needs \tn 
% Row Count 11 (+ 3)
% Row 5
\SetRowColor{white}
50 & Requires considerable assistance \& freq. medical care \tn 
% Row Count 13 (+ 2)
% Row 6
\SetRowColor{LightBackground}
40 & Disable ; req. special care \& assistance \tn 
% Row Count 15 (+ 2)
% Row 7
\SetRowColor{white}
30 & Severely disabled ; hospital admission is indicated although death not imminent \tn 
% Row Count 18 (+ 3)
% Row 8
\SetRowColor{LightBackground}
20 & Very sick ; hospital admission necessary ; active supportive treatment necessary \tn 
% Row Count 21 (+ 3)
% Row 9
\SetRowColor{white}
10 & Moribund ; fatal processess progressing rapidly \tn 
% Row Count 23 (+ 2)
% Row 10
\SetRowColor{LightBackground}
0 & Dead \tn 
% Row Count 24 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{3.833cm}}{100-80 -{}-\textgreater{} Able to carry on normal activity \& to work ; no special care needed \newline 70-50 -{}-\textgreater{}  Unable to work ; able to live at home \& care for most personal needs ; varying amount of assistance needed \newline 40-0 -{}-\textgreater{} Unable to care for self ; requires equivalent of institutional or hospital care ; disease may be progressing rapidly}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
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\begin{tabularx}{3.833cm}{X}
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\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Degree of Differentiation (G)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{Degree of differentiation often relates to clinical behavior of particular tumor} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{Based on microscopic appearance of cancer cells, pathologists commonly describe tumor grade by 4 degrees of severity} \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{Grade 1} \tn 
\mymulticolumn{1}{x{3.833cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Often well-differentiated / low-grade tumors \{\{nl\}\} Generally considered least aggressive in behaviour} \tn 
% Row Count 9 (+ 4)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{Grade 3/4} \tn 
\mymulticolumn{1}{x{3.833cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Usually poorly differentiated / undifferentiated high-grade tumors \{\{nl\}\} generally most aggressive in behaviour} \tn 
% Row Count 13 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{*Definition: Degree of abnormality of cancer cells, measure of differentiation, extent to which cancer cells are similar in appearance \& func. to healthy cells of same tissue type}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{x{1.51052 cm} x{1.92248 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Phases of Clinical Trials}}  \tn
% Row 0
\SetRowColor{LightBackground}
Phase I & First clinical trial of given agent in human being \{\{nl\}\} Goal:\{\{nl\}\} •Initial determination of safety of an agent administration \{\{nl\}\} •Determination of pharmacokinetic profile \tn 
% Row Count 9 (+ 9)
% Row 1
\SetRowColor{white}
Phase II & Initial trial of therapeutic efficacy \{\{nl\}\} •Preliminary determination of therapeutic efficacy \{\{nl\}\} •Determination of relationship b/w dose \& effect \{\{nl\}\} •Cont. of phase I safety determination \{\{nl\}\} •If necessary modification of dosage \tn 
% Row Count 21 (+ 12)
% Row 2
\SetRowColor{LightBackground}
Phase III & Systematic trial of therapeutic effectiveness \{\{nl\}\} •Evaluation in randomized, multicenter clinical trial in comparison to std. therapy also in double blind trial (not applicable to anticancer drugs, b/c there is no anticancer placebo effect) \{\{nl\}\} •Evaluation using pt. survival time \{\{nl\}\} •Cont. of evaluation of adverse reactions \& interaction w/ other concomitantly administered medicines \{\{nl\}\} -{}-{\emph{Kaplan-Meyer survival curve}}-{}- \tn 
% Row Count 42 (+ 21)
\end{tabularx}
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\vfill
\columnbreak
\begin{tabularx}{3.833cm}{x{1.51052 cm} x{1.92248 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Phases of Clinical Trials (cont)}}  \tn
% Row 3
\SetRowColor{LightBackground}
Phase IV & Trial performed after intro of new drug to market \{\{nl\}\} •New indications \{\{nl\}\} •New methods of administration \{\{nl\}\} •Combo w/ other new drugs unavailable in preregistration time \{\{nl\}\} •Comparison trials w/ other similar drugs \tn 
% Row Count 11 (+ 11)
% Row 4
\SetRowColor{white}
Meta-analysis {[}study of studies{]} & Formalized, systematic review of results of available phase II \& III trials (sometimes only phase III trials) on same subject \{\{nl\}\} Aim: \{\{nl\}\}•To increase precision \& significance of comparable trials through data aggregation \{\{nl\}\} •In case of contradictory results of indiv. trials reaching common conclusion \tn 
% Row Count 26 (+ 15)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}