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% Document Info
\author{nagabi}
\pdfinfo{
  /Title (endocrino-i-diabetes-mellitus-1.pdf)
  /Creator (Cheatography)
  /Author (nagabi)
  /Subject (Endocrino I: Diabetes Mellitus 1 Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
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    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Endocrino I: Diabetes Mellitus 1 Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{nagabi} via \textcolor{DarkBackground}{\uline{cheatography.com/196758/cs/41382/}}}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}nagabi \\
  \uline{cheatography.com/nagabi} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 22nd November, 2023.\\
   Page {\thepage} of \pageref{LastPage}.
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  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Conceito}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Distúrbio metabólico em que ocorre um constante estado de {\bf{hiperglicemia permanente}} devido uma {\bf{deficiência na produção de insulina}}.\{\{nl\}\} - DM1 acomete cerca de {\bf{10\% dos pacientes}} com algum tipo de diabetes\{\{nl\}\}- costuma acometer paciente desde o {\bf{período gestacional até 30 anos}}.% Row Count 7 (+ 7)
} \tn 
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Etiologia}}  \tn
% Row 0
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\mymulticolumn{1}{x{8.4cm}}{{\bf{DM1A (Autoimune) -}} linfócitos T autoimune ativados devido presença de auto-anticorpos} \tn 
% Row Count 2 (+ 2)
% Row 1
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\mymulticolumn{1}{x{8.4cm}}{{\bf{DM1B (Idiopática)}}} \tn 
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Fatores de Risco}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{Obesidade} \tn 
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\mymulticolumn{1}{x{8.4cm}}{Sedentarismo} \tn 
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\mymulticolumn{1}{x{8.4cm}}{Dislipdemia} \tn 
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\mymulticolumn{1}{x{8.4cm}}{Histórico Familiar} \tn 
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\mymulticolumn{1}{x{8.4cm}}{Síndrome do Ovário Policístico (SOP)} \tn 
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Fisiopatologia}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{A fisiopatologia da DM1 é multifatorial, mas de forma geral ela ocorre devido a destruição auto estimulada das células β-pancreáticas pelos linfócitos T devido a presença de anticorpos, sendo os principais o Auto-Antiinsulina, Anti-GAD, etc..\{\{nl\}\}Somente apresentará sintomas após a destruição de 80\% das células pancreáticas.% Row Count 7 (+ 7)
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Manifestações Clínicas}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{{\bf{Polidipsia}} aka sede anormal ou excessiva} \tn 
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% Row 1
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\mymulticolumn{1}{x{8.4cm}}{{\bf{Poliúria}} ou {\bf{Noctúria}} aka urinação excessiva em geral ou à noite} \tn 
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\mymulticolumn{1}{x{8.4cm}}{{\bf{Polifagia}} aka fome excessiva} \tn 
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\mymulticolumn{1}{x{8.4cm}}{{\bf{Perda de Peso Ponderal}} aka perda de peso sem motivo aparente} \tn 
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\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Diagnóstico}}  \tn
% Row 0
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\mymulticolumn{3}{x{8.4cm}}{Clínico} \tn 
% Row Count 1 (+ 1)
% Row 1
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\seqsplit{Laboratórial} & {\bf{Glicemia em Jejum\{\{nl\}\}TOTG\{\{nl\}\}Glicemia Ocasional\{\{nl\}\}Hemoglobina Glicada}} & {\bf{≥ 126\{\{nl\}\}≥ 200\{\{nl\}\}≥ 200 + sintomas\{\{nl\}\}≥ 6,5}} \tn 
% Row Count 6 (+ 5)
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\seqsplit{Imunológico} & AAI\{\{nl\}\}Anti - GAD &  \tn 
% Row Count 9 (+ 3)
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\mymulticolumn{3}{x{8.4cm}}{Deve-se levar em conta que todos os exames laboratoriais, exceto a hemoglobina glicada, necessitam de {\bf{duas aferições}} em períodos separados para fechar o diagnóstico.}  \tn 
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Diagnóstico Diferencial}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{Diabetes Autoimune Latente do Adulto (LADA) - DM autoimune que se desenvolve tardiamente, entre 30 a 45 anos} \tn 
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% Row 1
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\mymulticolumn{1}{x{8.4cm}}{Diabetes Mellitus Tipo 2 (DM2) - DM causada por resistência insulinica, que se estabelece após os 50-60 anos} \tn 
% Row Count 6 (+ 3)
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Complicações}}  \tn
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Agudas & {\bf{Cetoacidose Diabética (CAD)}} \tn 
% Row Count 1 (+ 1)
% Row 1
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\seqsplit{Crônicas} & {\bf{Cardiopatias }}(ex: infarto e AVE)\{\{nl\}\}{\bf{Nefropatia\{\{nl\}\}Neuropatia Periférica\{\{nl\}\}Retinopatia\{\{nl\}\} Amputação}} (por lesões e/ou necrose tecidual) \tn 
% Row Count 6 (+ 5)
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Tratamento}}  \tn
% Row 0
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\mymulticolumn{2}{x{8.4cm}}{Mudanças no Estilo de Vida (MEV's)} \tn 
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% Row 1
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{\bf{Insulina Exógena}} & {\bf{Insulina Basal}}: 0,5 a 1 (UI/kg/dia) antes da puberdade e até 2 (UI/kg/dia) após a puberdade\{\{nl\}\}{\bf{Insulina em Bolus (pré-refeição):}} metade da dose diaria de insulina dividida em 3x ao dia\{\{nl\}\}{\bf{Insulina em Bolus (correção):}} calculada pela relação carboidrato/insulina (costuma ser 1UI para cada 5-10 g de carboidrato) \tn 
% Row Count 14 (+ 13)
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\mymulticolumn{2}{x{8.4cm}}{Exemplo 1 : Paciente Pré-Púbere com 95 kg\{\{nl\}\}{\bf{Insulina Basal:}} 95 UI/kg/dia\{\{nl\}\}{\bf{Insulina Pré-Refeição:}}15,8 UI - 30 min antes das principais refeições\{\{nl\}\}{\bf{Insulina de Correção:}} considerando a ingestão de 50g de carboidrato, seriam aplicados 5 UI após a refeição\{\{nl\}\}}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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% That's all folks
\end{multicols*}

\end{document}