\documentclass[10pt,a4paper]{article} % Packages \usepackage{fancyhdr} % For header and footer \usepackage{multicol} % Allows multicols in tables \usepackage{tabularx} % Intelligent column widths \usepackage{tabulary} % Used in header and footer \usepackage{hhline} % Border under tables \usepackage{graphicx} % For images \usepackage{xcolor} % For hex colours %\usepackage[utf8x]{inputenc} % For unicode character support \usepackage[T1]{fontenc} % Without this we get weird character replacements \usepackage{colortbl} % For coloured tables \usepackage{setspace} % For line height \usepackage{lastpage} % Needed for total page number \usepackage{seqsplit} % Splits long words. %\usepackage{opensans} % Can't make this work so far. Shame. Would be lovely. \usepackage[normalem]{ulem} % For underlining links % Most of the following are not required for the majority % of cheat sheets but are needed for some symbol support. \usepackage{amsmath} % Symbols \usepackage{MnSymbol} % Symbols \usepackage{wasysym} % Symbols %\usepackage[english,german,french,spanish,italian]{babel} % Languages % Document Info \author{MJC3} \pdfinfo{ /Title (tablet-manufacture.pdf) /Creator (Cheatography) /Author (MJC3) /Subject (Tablet Manufacture Cheat Sheet) } % Lengths and widths \addtolength{\textwidth}{6cm} \addtolength{\textheight}{-1cm} \addtolength{\hoffset}{-3cm} \addtolength{\voffset}{-2cm} \setlength{\tabcolsep}{0.2cm} % Space between columns \setlength{\headsep}{-12pt} % Reduce space between header and content \setlength{\headheight}{85pt} % If less, LaTeX automatically increases it \renewcommand{\footrulewidth}{0pt} % Remove footer line \renewcommand{\headrulewidth}{0pt} % Remove header line \renewcommand{\seqinsert}{\ifmmode\allowbreak\else\-\fi} % Hyphens in seqsplit % This two commands together give roughly % the right line height in the tables \renewcommand{\arraystretch}{1.3} \onehalfspacing % Commands \newcommand{\SetRowColor}[1]{\noalign{\gdef\RowColorName{#1}}\rowcolor{\RowColorName}} % Shortcut for row colour \newcommand{\mymulticolumn}[3]{\multicolumn{#1}{>{\columncolor{\RowColorName}}#2}{#3}} % For coloured multi-cols \newcolumntype{x}[1]{>{\raggedright}p{#1}} % New column types for ragged-right paragraph columns \newcommand{\tn}{\tabularnewline} % Required as custom column type in use % Font and Colours \definecolor{HeadBackground}{HTML}{333333} \definecolor{FootBackground}{HTML}{666666} \definecolor{TextColor}{HTML}{333333} \definecolor{DarkBackground}{HTML}{CC2939} \definecolor{LightBackground}{HTML}{FBF1F2} \renewcommand{\familydefault}{\sfdefault} \color{TextColor} % Header and Footer \pagestyle{fancy} \fancyhead{} % Set header to blank \fancyfoot{} % Set footer to blank \fancyhead[L]{ \noindent \begin{multicols}{3} \begin{tabulary}{5.8cm}{C} \SetRowColor{DarkBackground} \vspace{-7pt} {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}} } \end{tabulary} \columnbreak \begin{tabulary}{11cm}{L} \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Tablet Manufacture Cheat Sheet}}}} \\ \normalsize{by \textcolor{DarkBackground}{MJC3} via \textcolor{DarkBackground}{\uline{cheatography.com/212269/cs/46151/}}} \end{tabulary} \end{multicols}} \fancyfoot[L]{ \footnotesize \noindent \begin{multicols}{3} \begin{tabulary}{5.8cm}{LL} \SetRowColor{FootBackground} \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}} \\ \vspace{-2pt}MJC3 \\ \uline{cheatography.com/mjc3} \\ \end{tabulary} \vfill \columnbreak \begin{tabulary}{5.8cm}{L} \SetRowColor{FootBackground} \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}} \\ \vspace{-2pt}Published 18th April, 2025.\\ Updated 18th April, 2025.\\ Page {\thepage} of \pageref{LastPage}. \end{tabulary} \vfill \columnbreak \begin{tabulary}{5.8cm}{L} \SetRowColor{FootBackground} \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}} \\ \SetRowColor{white} \vspace{-5pt} %\includegraphics[width=48px,height=48px]{dave.jpeg} Measure your website readability!\\ www.readability-score.com \end{tabulary} \end{multicols}} \begin{document} \raggedright \raggedcolumns % Set font size to small. Switch to any value % from this page to resize cheat sheet text: % www.emerson.emory.edu/services/latex/latex_169.html \footnotesize % Small font. \begin{multicols*}{4} \begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} } \SetRowColor{DarkBackground} \mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{The Hardness Test (Manual Tester)}} \tn % Row 0 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{1.The tablet is placed between the jaws (across its diameter), so that it is just held in place.} \tn % Row Count 2 (+ 2) % Row 1 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{2.The scale is then adjusted until it reads zero.} \tn % Row Count 3 (+ 1) % Row 2 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{3. The screw is then turned until the tablet breaks.} \tn % Row Count 5 (+ 2) % Row 3 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{4. The breaking force is then read off the scale to one decimal place.} \tn % Row Count 7 (+ 2) \hhline{>{\arrayrulecolor{DarkBackground}}--} \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{With this equipment, the value shown on the scale needs to be multiplied by 9.81 in order to convert it into Newtons. \newline One {\bf{advantage}} of the manual tester is that it is obvious when the tablet has broken.} \tn \hhline{>{\arrayrulecolor{DarkBackground}}--} \end{tabularx} \par\addvspace{1.3em} \begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} } \SetRowColor{DarkBackground} \mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Dissolution}} \tn % Row 0 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{6 tablets from each batch are tested.} \tn % Row Count 1 (+ 1) % Row 1 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{To pass the test all tablets should have more than 75\% of their API dissolved within 45 minutes.} \tn % Row Count 3 (+ 2) \hhline{>{\arrayrulecolor{DarkBackground}}--} \end{tabularx} \par\addvspace{1.3em} \begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} } \SetRowColor{DarkBackground} \mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{The Hardness Test (Electronic Tester)}} \tn % Row 0 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{1.The tablet is placed between the two plates} \tn % Row Count 1 (+ 1) % Row 1 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{2.The machine is zeroed and the screw is turned.} \tn % Row Count 2 (+ 1) % Row 2 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{3.The tablet doesn't break in quite such a spectacular way as the manual tester but cracks in two.} \tn % Row Count 4 (+ 2) % Row 3 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{4. If you listen carefully then you can hear the tablet break.} \tn % Row Count 6 (+ 2) \hhline{>{\arrayrulecolor{DarkBackground}}--} \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{{\bf{The electronic display shows the breaking force in Newtons so no need for conversion.}} \newline The BP doesn't give limits for the Hardness test. These are set by the tablet manufacturers and they depend upon factors such as how hard the tablets need to be in order to withstand the company's automated packaging equipment. \newline {\bf{Typical values would be:}} \newline Mean Breaking Force \textgreater{} 60.0 N \newline Standard Deviation \textless{} 5.0 N \newline {\bf{Both of these criteria would need to be met in order to pass the test.}}} \tn \hhline{>{\arrayrulecolor{DarkBackground}}--} \end{tabularx} \par\addvspace{1.3em} \begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} } \SetRowColor{DarkBackground} \mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Friability}} \tn % Row 0 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{1.Take 20 tablets, put them on a sieve and clean any powders or particles from their surface using a brush.} \tn % Row Count 3 (+ 3) % Row 1 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{2.Weigh the 20 Tablets collectively and record the total weight.} \tn % Row Count 5 (+ 2) % Row 2 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{3.Place the tablets inside the drum of the friability tester device, close and put in place and run (the run is set to 100 cycles).} \tn % Row Count 8 (+ 3) % Row 3 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{4.At the end of the run, weigh the tablets collectively again.} \tn % Row Count 10 (+ 2) % Row 4 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{5.Calculate the total weight loss as percentage of the initial weight.} \tn % Row Count 12 (+ 2) \hhline{>{\arrayrulecolor{DarkBackground}}--} \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{✅If the weight loss is {\bf{less than 1\%}} the tablets pass the test. \newline ❌If the weight loss is {\bf{more than 1\% or there are any cracked or broken tablets}} the test fails. \newline ❌If the test failed, it must be repeated again, if it failed the 2nd time its reported as fail. \newline ✅If it passed the 2nd time, it has to be repeated one more time to decide if it's a pass or fail.} \tn \hhline{>{\arrayrulecolor{DarkBackground}}--} \end{tabularx} \par\addvspace{1.3em} \begin{tabularx}{3.833cm}{x{1.7165 cm} x{1.7165 cm} } \SetRowColor{DarkBackground} \mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Uniformity of Mass}} \tn % Row 0 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{1. Weigh 20 tablets individually. Record the weight of each tablet precisely (4 decimal points).} \tn % Row Count 2 (+ 2) % Row 1 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{2.Calculate the mean (average) weight of the 20 tablets.} \tn % Row Count 4 (+ 2) % Row 2 \SetRowColor{LightBackground} 3. The tablets should be within the following weight range: & Mean -5\% \textless{} weight of the tablet\textless{} Mean + 5\% \tn % Row Count 7 (+ 3) \hhline{>{\arrayrulecolor{DarkBackground}}--} \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{{\bf{Criteria for passing the test:}} \newline No more than 2 tablets are outside this range \newline No tablet is more than 10\% different from the mean. \newline {\bf{Both of these criteria must be met for passing the test.}}} \tn \hhline{>{\arrayrulecolor{DarkBackground}}--} \end{tabularx} \par\addvspace{1.3em} \begin{tabularx}{3.833cm}{p{0.3433 cm} p{0.3433 cm} } \SetRowColor{DarkBackground} \mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Disintegration}} \tn % Row 0 \SetRowColor{LightBackground} \mymulticolumn{2}{x{3.833cm}}{6 tablets from each batch are tested.} \tn % Row Count 1 (+ 1) % Row 1 \SetRowColor{white} \mymulticolumn{2}{x{3.833cm}}{If all tablets disintegrate within 15 minutes the batch passes.} \tn % Row Count 3 (+ 2) \hhline{>{\arrayrulecolor{DarkBackground}}--} \end{tabularx} \par\addvspace{1.3em} % That's all folks \end{multicols*} \end{document}