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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
%\usepackage[english,german,french,spanish,italian]{babel}              % Languages

% Document Info
\author{Shelbi (kfisher17)}
\pdfinfo{
  /Title (cardio-exam-4.pdf)
  /Creator (Cheatography)
  /Author (Shelbi (kfisher17))
  /Subject (Cardio Exam 4 Cheat Sheet)
}

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% Commands
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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Cardio Exam 4 Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Shelbi (kfisher17)} via \textcolor{DarkBackground}{\uline{cheatography.com/79317/cs/19239/}}}
\end{tabulary}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Shelbi (kfisher17) \\
  \uline{cheatography.com/kfisher17} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 1st April, 2019.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{1.728 cm} x{1.512 cm} x{2.592 cm} x{1.368 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{8.4cm}}{\bf\textcolor{white}{Anticoagulants \& Fibrinolytics}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Generic}} & {\bf{Brand}} & {\bf{Class}} & {\bf{Form}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Heparin & UFH \seqsplit{(abbreviation)} & HMWH & {\emph{PAR}} \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Enoxaparin} & Lovenox & LMWH & {\emph{PAR}} \tn 
% Row Count 7 (+ 2)
% Row 3
\SetRowColor{white}
\seqsplit{Dalteparin} & Fragmin & LMWH & {\emph{PAR}} \tn 
% Row Count 9 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Warfarin & \seqsplit{Coumadin} & Coumarin Derivative \{\{nl\}\} (Vit K Antag.) & {\emph{PO}} \tn 
% Row Count 12 (+ 3)
% Row 5
\SetRowColor{white}
\seqsplit{Dabigatran} & Pradaxa & Direct Thrombin Inhibitor & {\emph{PO}} \tn 
% Row Count 14 (+ 2)
% Row 6
\SetRowColor{LightBackground}
\seqsplit{Fondaparinux} & Arixtra & Xa Inhibitor & {\emph{PAR}} \tn 
% Row Count 16 (+ 2)
% Row 7
\SetRowColor{white}
Apixaban & Eliquis & Xa Inhibitor & {\emph{PAR}} \tn 
% Row Count 17 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\seqsplit{Rivaroxaban} & Xarelto & Xa Inhibitor & {\emph{PO}} \tn 
% Row Count 19 (+ 2)
% Row 9
\SetRowColor{white}
Edoxaban & Savaysa & Xa Inhibitor & {\emph{PO}} \tn 
% Row Count 20 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\seqsplit{Betrixaban} & Bevyxxa & Xa Inhibitor & {\emph{PO}} \tn 
% Row Count 22 (+ 2)
% Row 11
\SetRowColor{white}
\seqsplit{Alteplase} \{\{nl\}\} t-PA & \seqsplit{Activase} \{\{nl\}\} Cathflo & Fibrinolytic & {\emph{IV Bolus \& Infusion}} \tn 
% Row Count 25 (+ 3)
% Row 12
\SetRowColor{LightBackground}
\seqsplit{Reteplase} \{\{nl\}\} rPA & \seqsplit{Retavase} & Fibrinolytic & {\emph{IV Bolus}} \tn 
% Row Count 28 (+ 3)
% Row 13
\SetRowColor{white}
\seqsplit{Tenecteplase} \{\{nl\}\} TNK-tPA & TNKase & Fibrinolytic & {\emph{IV Bolus}} \tn 
% Row Count 31 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.9 cm} x{2.888 cm} x{2.812 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Drug Site of Action in Coagulation Cascade}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Class}} & {\bf{Drugs}} & {\bf{Site of Action}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{Unfractionated} Heparin & Heparin & ATIII, Xa, IIa, VIIa, IXa, XIa, \& XIIa \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
LMWH & Enoxaparin, Dalteparin & ATIII, Xa, IIa \tn 
% Row Count 7 (+ 2)
% Row 3
\SetRowColor{white}
Factor Xa Inhibitor & Fondaparinux & ATIII, Xa \tn 
% Row Count 9 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Vit K \seqsplit{Antagonist} & Warfarin & II, VII, IX, \& X \tn 
% Row Count 11 (+ 2)
% Row 5
\SetRowColor{white}
Oral Xa \seqsplit{Inhibitors} & Apixaban, Rivaroxaban, Edoxaban, Betrixaban & Xa \tn 
% Row Count 14 (+ 3)
% Row 6
\SetRowColor{LightBackground}
Direct Thrombin \seqsplit{Inhibitors} & Dabigatran & IIa (Thrombin) \tn 
% Row Count 17 (+ 3)
% Row 7
\SetRowColor{white}
\seqsplit{Fibrinolytics} & Alteplase \{\{nl\}\} Reteplase \{\{nl\}\} Tenectaplase & Fibrin \tn 
% Row Count 21 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.584 cm} x{2.508 cm} x{2.508 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{MOA for Therapies}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Drug}} & {\bf{MOA}} & {\bf{Result}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Heparin & \{\{fa-arrow-up\}\} fxn of ATIII \{\{nl\}\} Significant inhibition of {\bf{Xa \& IIa}} \{\{nl\}\} Minor Inhibitor of {\bf{VIIa, IXa, XIa, \& XIIa}} & ACF become inactivated \tn 
% Row Count 11 (+ 10)
% Row 2
\SetRowColor{LightBackground}
Enoxaparin \{\{nl\}\} Dalteparin & \{\{fa-arrow-up\}\} fxn of ATIII \{\{nl\}\} Significant inhibition of Xa \{\{nl\}\} Some inhibition of IIa & ACF become inactivated \tn 
% Row Count 19 (+ 8)
% Row 3
\SetRowColor{white}
Fondaparinux & \{\{fa-arrow-up\}\} fxn of ATIII \{\{nl\}\} Significant inhibition of Xa \{\{nl\}\} Inhibition {\bf{specific}} to Xa & ACF become inactivated \tn 
% Row Count 27 (+ 8)
% Row 4
\SetRowColor{LightBackground}
Warfarin & Targets Vit K dependent clotting factors (II, VII, IX, \& X) \{\{nl\}\} {\bf{Inhibits VKORC1}} \{\{nl\}\} & \{\{fa-arrow-down\}\} KH2 \{\{nl\}\} KH2 is needed as a cofactor for carboxylase enzyme to activate dependent clotting factors \{\{nl\}\} \{\{fa-arrow-down\}\} Vit K dependent clotting factors are produced \{\{nl\}\} \{\{fa-arrow-down\}\} F II, VII, IX, \& X \tn 
% Row Count 45 (+ 18)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{8.4cm}{x{2.584 cm} x{2.508 cm} x{2.508 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{MOA for Therapies (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
Apixaban \{\{nl\}\} Rivaroxaban \{\{nl\}\} Edoxaban \{\{nl\}\} Betrixaban & {\bf{Blocks the active site}} for Factor Xa \{\{nl\}\} Does not affect antithrombin & {\bf{Direct inhibition}} of Factor Xa \tn 
% Row Count 6 (+ 6)
% Row 6
\SetRowColor{white}
Dabigatran & {\bf{Directly}} inhibits Factor IIa (Thrombin) & No conversion of fibrinogen to fibrin \{\{nl\}\} Prevents development of a thrombus \tn 
% Row Count 13 (+ 7)
% Row 7
\SetRowColor{LightBackground}
Alteplase \{\{nl\}\} (t-PA/r-tPA) & Converts {\bf{plasminogen}} to {\bf{plasmin}} & Breaks up clot \tn 
% Row Count 16 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{{\bf{ACF}}: Active Clotting Factors \newline {\bf{VKORC1}}: Vit K Epoxide Reductase - {\emph{Enzyme responsible for converting Vit K epoxide to its reduced and active form (KH2)}} \newline {\bf{KH2}}: Active Vit K}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}