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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
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% Document Info
\author{imanf}
\pdfinfo{
  /Title (pharmacology.pdf)
  /Creator (Cheatography)
  /Author (imanf)
  /Subject (Pharmacology Cheat Sheet)
}

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% Commands
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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Pharmacology Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{imanf} via \textcolor{DarkBackground}{\uline{cheatography.com/55634/cs/15059/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}imanf \\
  \uline{cheatography.com/imanf} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 10th March, 2018.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Introduction}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{\{\{nobreak\}\} Founded by German Professor Rudolf Buchheim (1820 - 1879)} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{He introduced 2 important prinicples: \{\{nl\}\} - The natural system of drug classification based on their mode of action \{\{nl\}\} - experimental pharmacology} \tn 
% Row Count 6 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Milestones}} \{\{nl\}\}	- 1806: Morphine \{\{nl\}\}	- 1908: Sulfanilamide (first-antibacterial) \{\{nl\}\}	 - 1912: Phenobarbital (first ant-epileptic) \{\{nl\}\}	 - 1921: Insulin \{\{nl\}\}	1956: Tolbutamide (first oral anti-hyperglycemic) \{\{nl\}\}	- 1957: Propanolol (first Beta blocker) \{\{nl\}\}	- 1961: L-DOPA (Parkinson's disease) \{\{nl\}\}	- 1975: ACE inhibitors (first-line for HTN)} \tn 
% Row Count 14 (+ 8)
% Row 3
\SetRowColor{white}
{\bf{Pharmacology before 19\textasciicircum{}th\textasciicircum{} Century}} & - Made at home, by apothecary, by unregulated commercial interests \{\{nl\}\} - marketed w/o evidence or understanding \{\{nl\}\} - Spiritual-based healing was popular and successful \tn 
% Row Count 23 (+ 9)
% Row 4
\SetRowColor{LightBackground}
{\bf{Pharmacology in the 21\textasciicircum{}st\textasciicircum{} Century}} & - Emphasis on molecules and cells as targets vs tissues, organs, and whole animals \{\{nl\}\} Human Genome Project (individualized medicine) \{\{nl\}\} - Drugs designed around a disease specific target \{\{nl\}\} - Examines interactions b/w drugs \& living organisms \tn 
% Row Count 36 (+ 13)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Introduction (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Definitions}} \{\{nl\}\} - {\emph{Pharmacology}}: Scientific discipline that investigates the interactions b/w living organisms and 'drugs' \{\{nl\}\} - {\emph{Drug}}: Chemical substance used in the treatment, cure, prevention, or diagnosis of disease. \{\{nl\}\} - {\emph{Pharmacokinetics}}: what the body does to drugs \{\{nl\}\} - {\emph{Pharmacodynamics}}: what the drugs do to the body \{\{nl\}\} - {\emph{Molecular Pharmacology}}: experimental pharmacology \{\{nl\}\} - {\emph{Clinical Pharmacology}}: science of using drugs in humans (clinical research), based on lab studies, seeks to understand how a drug should be used in practice \{\{nl\}\} - {\emph{Pharmacogenetics}}: why people respond to drugs differently} \tn 
% Row Count 13 (+ 13)
% Row 6
\SetRowColor{white}
\{\{nobreak\}\} {\bf{Drug Classification}} \{\{nl\}\} - Anatomical \{\{nl\}\} - Therapeutic use \{\{nl\}\} - Pharmacological mechanism \{\{nl\}\} - Chemical group \{\{nl\}\} - Chemical substance & {\bf{Drug Nomenclature}} \{\{nl\}\} - Chemical name \{\{nl\}\} - Generic name \{\{nl\}\} - Brand name \tn 
% Row Count 22 (+ 9)
% Row 7
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Physical Nature of Drugs}} \{\{nl\}\} - Pills are mainly inactive ingredients which help with the admin. of active ingredients \{\{nl\}\} - When molecules are very big they cannot be absorbed very well orally bc they cannot pass through the lipid bilayers \{\{nl\}\} - There may be different isotopes of drugs. Not all isotopes will be effective (D- form vs. L-form)} \tn 
% Row Count 30 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}

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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Pharmacodynamics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Drug Targets}} \{\{nl\}\} - Receptors \{\{nl\}\} - Enzymes \{\{nl\}\} - Carrier Molecules \{\{nl\}\} - Voltage-gated ion channels} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{{\emph{Receptors}} \{\{nl\}\} - {\bf{{\emph{Ionotropic}}}}: ion channel receptors, ions flow into the neuron, {\bf{mediates fast transmission}} \{\{nl\}\} ~	~	- Eg: cholinergic (nicotinic), GABAa \{\{nl\}\} - {\bf{{\emph{Metabotropic}}}}: G protein coupled (secondary messengers), {\bf{mediates slow transmission}}, change enzyme activity, protein expression, open slow ion channels \{\{nl\}\} ~~		- Eg: adrenergic, cholinergic (muscarinic), GABAb} \tn 
% Row Count 12 (+ 9)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Secondary Messengers}}: intracellular compounds that help to transduce ligand-binding to a physiological or pharmacological effect (cAMP, cGMP, PKA, PDE, Ca\textasciicircum{}2+\textasciicircum{})  \{\{nl\}\}~~~- Ligands or agonists are considered 'first messengers'} \tn 
% Row Count 17 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}