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% Document Info
\author{Hiral OT (Hiral)}
\pdfinfo{
  /Title (hiralot-adrenergic-drugs.pdf)
  /Creator (Cheatography)
  /Author (Hiral OT (Hiral))
  /Subject (HiralOT\_ADRENERGIC DRUGS Cheat Sheet)
}

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\noindent
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\begin{tabulary}{5.8cm}{C}
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    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{HiralOT\_ADRENERGIC DRUGS Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Hiral OT (Hiral)} via \textcolor{DarkBackground}{\uline{cheatography.com/31053/cs/9375/}}}
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\noindent
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Hiral OT (Hiral) \\
  \uline{cheatography.com/hiral} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 6th October, 2016.\\
   Updated 6th October, 2016.\\
   Page {\thepage} of \pageref{LastPage}.
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{tabularx}{5.377cm}{x{1.74195 cm} x{3.23505 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Beta 1 Selective Agonists}}  \tn
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Located at & Myocardium \tn 
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Stimulation results in & Increased Heart rate and increased force of myocardial contraction (Increased Cardiac output) \tn 
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USED FOR & To increase cardiac output in emergency situations such as CVS shock or to treat complications in Cardiac Surgery. \tn 
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also USED FOR & To increase cardiac function in the short-term treatment of certain type of heart disease, - heart failure \tn 
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Dobutamine (Dobutrex) & Use: Short term mx of Cardiac decompensation  that occurs during heart disease or heart surgery.  How: Increase force of cardiac contraction.  Adm: IV pump infusion  (to stable plasma levels) \tn 
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Dopamine (Intropin) & directly stimulates Beta 1.  Low DOSE: cause peripheral vasodilatation.  Adm: IV drip to maintain stable plasma levels \tn 
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ADVERSE Effects & Chest pain, difficulty in breathing \tn 
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\begin{tabularx}{5.377cm}{x{2.33919 cm} x{2.63781 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Beta 2 Selective Agonists}}  \tn
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Location & on bronchiole smooth muscle \tn 
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How & Stimulated Beta 2 -{}-\textgreater{} mediates relaxation of bronchioles \tn 
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Treat & Bronchospasm associated with respiratory ailments such as asthama, bronchitis, emphysema.  Treats ALSO Cardiac Arrythmias  or heart failure \tn 
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Another LOCATION & Uterine Muscle (When stimulated-{}-\textgreater{}cause inhibition or relaxation of the uterus) \tn 
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Beta 2 Selective Bronchodialators & Albuterol (Provventil, Ventolin), Metaproterenol (Alupent,), Pirbuterol (Maxair), Salmeterol (Servent), and Terbutaline (Brethaire, bricanyl). \tn 
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what it causes & Bronchodilatation at pulmonary smooth muscles - Asthma. \tn 
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Isoproterenol (Isuprel) & can be the same but: less beta 2 selective and affects beta 1 receptor too. \tn 
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Beta 2 Selective Agonists (cont)}}  \tn
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Adm & Oral inhalation so that affects on the bronchial membranes. \tn 
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Adverse Effect & nervousness, restlessness, trembling.  sometimes fatal asthamatic attaacks. \tn 
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When used to treat premature labor, & Terbutaline - increase in maternal heart rate and systolic blood pressure, as well as maternal pulmonary edema.  Sometimes fatal to mother. \tn 
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\begin{tabularx}{5.377cm}{x{1.89126 cm} x{3.08574 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Adrenergic Drugs}}  \tn
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Adrenergic & Refers physiological responses related to adrenaline and noradrenaline \tn 
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Other names & Adrenaline and NorAdrenalin = Epinephrine and NonEpinephrine \tn 
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Adrenergic Drugs & Stimulate activity in tissues that respond to Epi and NorEpi (Adrenergic agonists) OR inhibit epinephrine and norepinephrine influence (adrenergic antagonists) \tn 
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From where they release? & Adrenal gland and reach to Heart, Kidneys, and various other tissues and organs via systemic circulation. \tn 
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Where it is found & Junction between sympathetic postganglionic neurons and peripheral tissues \tn 
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Adrenergic agonists & Sympathomimetic \tn 
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Adrenergic antagonists & sypatholytic \tn 
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\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Subclassification of Adrenergic Drugs}}  \tn
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Adrenergic receptors can be divided into two & Alpha and Beta receptors \tn 
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Five receptor subtypes & Alph 1 (a, b, d) 2 (a, b, c) beta 1,2,3, \tn 
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Alpha 1 or alpha 2 & Located at specific tissues throughout the body-{}-\textgreater{} the responsed depend upon interaction between that receptor andthe reseptive tissue \tn 
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Agonist & Increase or mimic the receptor mediated response \tn 
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Antagonist & decrease the receptor mediated resonce \tn 
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Epinephrine drug & affects alpha and beta receptors Equally \tn 
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\mymulticolumn{2}{x{5.377cm}}{Receptor selectivity} \tn 
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\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{MIX ALPHA AND BETA}}  \tn
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Amphatamines & \seqsplit{Drugs:Amphetamine} (generic), \seqsplit{dextroamphetamine} (Dexedrine) and \seqsplit{methamphatamine} (Desoxyn) & Increase Norepi release and decrease NorEpi reuptake and breakdown at adrenergic synapses - so Increase activity at synapses with Norepi sesitive receptors - Alpha 1,2 and Beta1) \tn 
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% Row 1
\SetRowColor{white}
 & Used to treat \seqsplit{attention-deficit} disorder in children, to increase mental alertness in adults with narcolepsy. & The use to suppress appetite or to combat normal sleepiness is discourage- as they have high potential of abuse \tn 
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Ephendrine (Generic) & Stimulate Alpha 1, 2 and beta 1  and also stimulate the same by increasing release of norepi at synapses & Use: Primarily for Alpha 1 effects: treat hypotension. \tn 
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\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{MIX ALPHA AND BETA (cont)}}  \tn
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 & IV injection & ALSO a nasal \seqsplit{decongenstant} - stimulate alpha 1: combined with other agents \seqsplit{(antitussives}, \seqsplit{antihistamines)} to form cough and cold products \tn 
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 & As \seqsplit{Bronchodilator} & Narcolepsy treatment \tn 
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Epinphrine (Adrenalin, Bronkaid Mist, Primatene Mist, ) & All receptors are stimulated. & \seqsplit{Antiasthmatic} inhalation products.  - primary stimulate B2 bronchii. \tn 
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% Row 6
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 & Effect of Alpha 1 vascular & \seqsplit{vasoconstirction} and control of bleeding during minor surgical procedures (sutures). Prolongs effects of the anasthetics \tn 
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 & B1 effect on heart & reestablish normal cardiac rhythm during cardiac arrest. \tn 
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\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{MIX ALPHA AND BETA (cont)}}  \tn
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 & Drug of choice in Anaphylactic shock & \seqsplit{hypersensitive} allergic reaction marked by CVS collapse (decreased cardiac output, hypotension) and severe \seqsplit{bronchoconstriction}. \tn 
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why & Becase ability to & Stimulate heart (b1), \seqsplit{vasoconstriction} periphery (alpha 1) and Dilate bronchi (beta2). \tn 
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Metaraminol (aramine) & act like Epinephrine & Directly stimulates alpha 1, 2 and beta1 \tn 
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 & Treat & shock or general anasthesia \tn 
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\seqsplit{NorEpiNephrine} (Levophed) & Stimulates: Alpha 1, 2 and Beta 1. & displays little agonistic activity toward beta2. \tn 
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 & Adm IV injection & Treat: Hypotension during shock or general anasthesia. \tn 
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\begin{tabularx}{5.377cm}{x{1.55618 cm} x{1.51041 cm} x{1.51041 cm} }
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\mymulticolumn{3}{x{5.377cm}}{\bf\textcolor{white}{MIX ALPHA AND BETA (cont)}}  \tn
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Adverse Effect & Nervousness, restlessness, anxiety. & Prolonged use Causes- hypertension, arrhythmias, cardiac arrest. \tn 
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 &  & Prolonged Use in inhalation: Cause bronchial irritation. \tn 
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\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{ALPHA 1 SELECTIVE AGONISTS}}  \tn
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Alpha 1 or alpha 2 & Contraction and VasoConstriction : Increase BP \tn 
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Mephentermine (Wyamine) & Maintain/restore BP during hypotensive episodes. Administered: IV or IM injections. \tn 
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\seqsplit{Methoxamine(Vasoxyl)} & Increase and maintain BP in severe hypotension- during general anesthesia and spinal anesthesia.  Treats: Paroxymal sypraventricular tachycardia by causing  peripheral vasoconstriction, activation of baroreceptor reflex.  Adm : IV injection \tn 
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Midodrine (ProAmatine) & Treat: orthostatic hypotension  Adm: Orally Also: treat hypotension in patients who go under dialysis,  offset the hypotensive effects of psychotropic drugs like antipsychotic medications \tn 
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\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{ALPHA 1 SELECTIVE AGONISTS (cont)}}  \tn
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Oxymetazoline (Afrin, OcuClear, Many others) & Adm: naslal drops and nasal sprays.  Treat: Decrease nasal congestion and decrease redness and minor eye irritation \tn 
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Phenylephrine (Neo-Synephrine, Others) & Treat: hypotension,  treat certain episodes of supraventricular tachycardia.  Adm: Orally a lso or nasal spray, or topically as eye drops. \tn 
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Pseudoephedrine (Drixoral, Sudafed, etc) & Adm: Orally   - relieve cold symptoms \tn 
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Xylometazoline (Otrivin) & nasal spray to decrease congestion during cold and alergies. \tn 
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Adverse Effect: & increased BP, headache, abnormally slow heart rate,  sometimes chest pain, difficulty in breathing, feelings of nervousness \tn 
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\begin{tabularx}{5.377cm}{x{2.14011 cm} x{2.83689 cm} }
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{ALHA 2 SELECTIVE AGONISTS}}  \tn
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Primary use & Hypertension, spasticity.. \tn 
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How & Drug stimulate alpha-2 receptors located at brain and brainstem -{}-\textgreater{} cebtral alpha2 exert an inhibitory effect on sympathetic discharge from the vasomotor center in the brainstem -{}-{}-\textgreater{} diminished sympathetic discharge results in decreased BP. \tn 
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Also effective on Spinal cord & Stimulation of Alpha 2 -{}-\textgreater{} causes interneuron inhibition and a subsequent decrease in excitability of motor neurons supplied by interneurons.  USE TO normalize the neuronal activity in Spasticity \tn 
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Brimonidine (Alphagan) & Adm: local to eye to treat glaucoma.  (Decreases vitreous humor production and increasing drainage of vitreous humor from the eye) \tn 
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\SetRowColor{LightBackground}
Clonidine (Catapres, Duraclon) & Antihypertensive and analgesic, It does not effect ALONE. so given with PRAZOSIN (Minipress - alpha antagonists). also useful to treat severe pain in cancer. \tn 
% Row Count 36 (+ 8)
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\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{ALHA 2 SELECTIVE AGONISTS (cont)}}  \tn
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Guanabenz (Wytensin) & decrease BP (same as Clonidine) \tn 
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Guanfacine (Tenex) & similar to Guanabenz \tn 
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Methyldopa (Aldomet) & Antihypertensive. \tn 
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Tizanidine (Zanaflex) & To treat spasticity.  Similar to Clonidine but has fewer vasomotor effects and less likey to cause hypotension and other CVS problems. \tn 
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Adverse Effects & Hypotension, dizziness, drowsiness, dry mouth.  Difficulty in breathing, slow heart rate, persistent fainting - overdose of drugs. \tn 
% Row Count 19 (+ 6)
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\end{tabularx}
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% That's all folks
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