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\author{happyfeet2020}
\pdfinfo{
  /Title (antibiotic-pharmacology.pdf)
  /Creator (Cheatography)
  /Author (happyfeet2020)
  /Subject (Antibiotic Pharmacology Cheat Sheet)
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        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Antibiotic Pharmacology Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{happyfeet2020} via \textcolor{DarkBackground}{\uline{cheatography.com/144934/cs/31417/}}}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}happyfeet2020 \\
  \uline{cheatography.com/happyfeet2020} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 11th April, 2022.\\
   Updated 8th April, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
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  Measure your website readability!\\
  www.readability-score.com
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Gram Positive Bacteria}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{- Plasma membrane covered by thick peptidoglycan (murein) cell wall} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-Certain abx inhibit synthesis of the petidoglycan cell wall: penicillins, cephalosporins, bacitracin, vancomycin, monobactams and carbapenems} \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{-Blue purple stain} \tn 
% Row Count 6 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-most common aerobic gram + bacteria w/ podiatric complications: staphylococcus (grm += staph aureus, grm - = staph epidermidis), streptococcus - penicillin \seqsplit{sensitive/non-penicillinase} producing, methicillin resistant staph aureus, methicillin sensitive/penicillinase producing, vancomycin resistant  staph a and corynebacterium} \tn 
% Row Count 13 (+ 7)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Group A strep common in superficial skin infections (erysipelas)} \tn 
% Row Count 15 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Group B strep very common in diabetic foot infections} \tn 
% Row Count 17 (+ 2)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Group A and B strep sensitive to: penicillins, cephalosporins, clindamycin, erythromycin} \tn 
% Row Count 19 (+ 2)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Cornyebacterium minutissimum is implicated in erythrasma (treat with erythromycin)} \tn 
% Row Count 21 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{*If C\&S reports MRSA or group D strep (enterococci), consider infectious disease consult}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Gram Negative Bacteria}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{-Plasma membrane covered by a thinner peptidoglycan cell wall which is then covered w/ an outer lipopolysaccharide membrane} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-prohibits entry of most penicillins and cephalosporins} \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{- resists the uptake of blue dye so stains pink} \tn 
% Row Count 6 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{-Aerobic gram - pathogens: enterics like salmonella, klebsiella, proteus, etc, pseudomonas, etc} \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{some broad spectrum synthetic penicillins and 3rd gen cephalosporins (IV) may allow some entry through outer membrane. However, space b/ cell wall and outer membrane is high in B-lactamases which is a penicillin-destroying enzymes} \tn 
% Row Count 13 (+ 5)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{The addition of B-lactamase inhibitor (clavulanic acid) to a broad spectrum penicillin may increase its spectrum of activity to include some gram - coverage} \tn 
% Row Count 17 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{*possible to have a mixed gram + and gram - bacteria (ie diabetic foot that has been exposed)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anaerobes}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{-infections often composed of mixed gm+ and gm- bacteria} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{produce foul smelling gas and frequently encased in abscess wall} \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{common anaerobes: clostridium which respond well to penicillin, clindamycin and tetracyline. infection may be aggressive and may need iV therapy and surgical intervention} \tn 
% Row Count 8 (+ 4)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Bacteroids are also a common anaerobe which is a gm- bacillus. They are common in diabetic foot infections. Abx therapy include PO clindamycine, amoxi clav.} \tn 
% Row Count 12 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.64241 cm} x{3.33459 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{inhibitors of Cell Wall Synthesis - B-Lactams}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{MOA:}} & The final step in bacterial cell wall synthesis is cross linking of adjacent peptidoglycan strands. B-lactams bind to transpeptidase (penicillin binding proteins) prevents crosslinking of peptidoglycan strands in cell wall during wall synthesis leading to weakened cell wall and eventually cell death \tn 
% Row Count 12 (+ 12)
% Row 1
\SetRowColor{white}
{\bf{Penicillins:}} & {\emph{Natural PCNs}} \tn 
% Row Count 14 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & {\emph{Penicillinase Resistant PCNs}} (Cloxacillin) - good for strep, penicillinase producing staph, anaerobes except bacteroides \tn 
% Row Count 19 (+ 5)
% Row 3
\SetRowColor{white}
 & {\emph{Aminopenicillins}} (Amoxicillin) - good for strep, gm- organisms, non penicillinase producing staph, anaerobes other than bacteroids \tn 
% Row Count 25 (+ 6)
% Row 4
\SetRowColor{LightBackground}
 & {\emph{Penicillin/B-Lactamase Inhibitor}} (Amoxicillin clavulanate)- good for strep, increase in gm - (not pseudomonas), penicillinase producing staph, anaerobes including bacteroides. Beta-lactamase inhibitors are a class of medicine that block the activity of beta-lactamase enzymes (also called beta-lactamases), preventing the degradation of beta-lactam antibiotics ie amoxicillin which can be restored and widened with clavulanate \tn 
% Row Count 42 (+ 17)
\end{tabularx}
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\vfill
\columnbreak
\begin{tabularx}{5.377cm}{x{1.64241 cm} x{3.33459 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{inhibitors of Cell Wall Synthesis - B-Lactams (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
 & Most PCNs are excreted unchanged via renal tubular mechanism, therefore dosages must be adjusted in pts w/depressed renal function \tn 
% Row Count 5 (+ 5)
% Row 6
\SetRowColor{white}
 & PCNs are bacteriocidal \tn 
% Row Count 6 (+ 1)
% Row 7
\SetRowColor{LightBackground}
 & {\emph{Side effects:}} anaphylaxis, 5-15\% cross sensitivity w/ cephs, rash/dermatitis, nephritis, diarrhea, enterocolitis \tn 
% Row Count 11 (+ 5)
% Row 8
\SetRowColor{white}
{\bf{ Cephalosporins:}} & 1st Gen- Cephalexin, Cefadroxil. Good for gm+ staph (penicillinase \& non-penicillinase producing except MRSA), \& strep, okay against gm- and anaerobes other than bacteroids \tn 
% Row Count 18 (+ 7)
% Row 9
\SetRowColor{LightBackground}
 & Most cephalosporins are excreted unchanged via renal tubular mechanisms (secretion). need to adjust dosage in pts w/ reduced renal function \tn 
% Row Count 24 (+ 6)
% Row 10
\SetRowColor{white}
 & Bacteriocidal activity \tn 
% Row Count 25 (+ 1)
% Row 11
\SetRowColor{LightBackground}
 & {\emph{Side effects:}}  same as penicillins \tn 
% Row Count 27 (+ 2)
% Row 12
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Carbapenems}}} \tn 
% Row Count 28 (+ 1)
% Row 13
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{{\bf{Monobactams}}} \tn 
% Row Count 29 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.34379 cm} x{3.63321 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Cell Wall Synthesis inhibitor- Glycopeptides}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Bacitracin}}: & MOA: glycopeptide that inhibits cell wall synthesis by preventing transport of cell wall precursors \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
 & Activity against gm+ and some gm-. However pseudomonas is resistant \tn 
% Row Count 7 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & side effects: nephrotoxic, neurotoxic and toxic to bone marrow if used systemically therefore only used topically \tn 
% Row Count 11 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.28942 cm} x{2.68758 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Folate Antagonists}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Sulfonamides/Trimethoprim}} & Synergists -\textgreater{} produces a greater effect when used together \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & MOA: Bacteria synthesize folate from pteridine \& PABA, whereas humans require dietary folate b/c humans don't have the enzymes seen in this bacterial pathway, these abx are relatively free of adverse effects. Prevents formation of folate at step and ultimately, the synthesis of bacterial purines and DNA, resulting in a bacteriostatic effect. \tn 
% Row Count 20 (+ 17)
% Row 2
\SetRowColor{LightBackground}
 & Metabolized in liver \tn 
% Row Count 21 (+ 1)
% Row 3
\SetRowColor{white}
{\bf{Sulfametathoazole/Trimethoprim}} & effective against Gm+ organisms \& some strains of MRSA, excellent coverage of Gm-, except pseudomonas \tn 
% Row Count 26 (+ 5)
% Row 4
\SetRowColor{LightBackground}
 & Bacteriostatic, renal clearance \tn 
% Row Count 28 (+ 2)
% Row 5
\SetRowColor{white}
 & Side effects: allergic reactions in 30\% population (potentially fatal), diarrhea, N/V, compete w/bilirubin for binding sites on serum albumin -\textgreater{} kernicterus in newborns (increase bilirubin levels) , hemolytic anemia in pts w. G6PD deficiency, renal clearance \tn 
% Row Count 41 (+ 13)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.4931 cm} x{3.4839 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Folate Antagonists- Quinolones}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{MOA}}: & Inhibit DNA synthesis through a specific action on DNA gyrase or topoisomerase IV. Topoisomerases (DNA gyrase or topoisomerase IV) bind to DNA -\textgreater{} transient cleave complexes (double stranded breaks). In presence of quinolones, levels of cleavage increase dramatically. After traversal by replication complexes, these breaks become permanent double stranded fractures -\textgreater{} cell death \tn 
% Row Count 14 (+ 14)
% Row 1
\SetRowColor{white}
{\bf{Ciprofloxacin}} & Excellent activity against all Gm- organisms, including pseudomonas. Marginal activity against staph A, including some strains of MRSA, minimal activity against strep or anaerobes \tn 
% Row Count 21 (+ 7)
% Row 2
\SetRowColor{LightBackground}
 & 100\% bioavailability, renal and hepatic clearance, bacteriocidal \tn 
% Row Count 24 (+ 3)
% Row 3
\SetRowColor{white}
 & Best bet for highly suspected Gm- or pseudomonas bacteria \tn 
% Row Count 27 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & {\emph{Side effects}}: N/v, contraindicated in children with open growth plates due to to possible cartilage degeneration, tendon degeneration, peripheral neuropathy, mental health side effects and blood sugar disturbances (hypoglycaemic coma), concomitant NSAID use may increase risk of CNS stimulation and convulsions, aortic aneurysm, highest risk of causing colonization w/MRSA and C.difficle \tn 
% Row Count 41 (+ 14)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Antibiotic Mechanism of Action}}  \tn
\SetRowColor{LightBackground}
\mymulticolumn{1}{p{5.377cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/happyfeet2020_1648584745_abx picture.jpeg}}} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.33919 cm} x{2.63781 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Inhibitors of Protein Synthesis- 30S Subunit}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Tetracyclines}} & MOA: bind reversibly to the 30S ribosomal subunit at a position that blocks the binding of the aminoacyl-tRNA to the acceptor site on the mRNA-ribosome complex. Protein synthesis is ultimately inhibited, leading to a bacteriostatic effect \tn 
% Row Count 12 (+ 12)
% Row 1
\SetRowColor{white}
 & effective against gm+ except MRSA, few gm- and some anaerobes (no bacteroides) \tn 
% Row Count 16 (+ 4)
% Row 2
\SetRowColor{LightBackground}
 & Bacteriostatic, renal clearance \tn 
% Row Count 18 (+ 2)
% Row 3
\SetRowColor{white}
 & {\emph{Side effects}}: possible allergic rxn, diarrhea+ N/V, thrombophlebitis, photosensitivity, kidney toxicity, interaction w/calcium, need to be taken on empty stomach \tn 
% Row Count 26 (+ 8)
% Row 4
\SetRowColor{LightBackground}
{\bf{Aminoglycosides}} (Gentamycin,etc) & Effective against aerobic gm- and pseudomonas, not effective against anaerobes \tn 
% Row Count 30 (+ 4)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
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\begin{tabularx}{5.377cm}{x{2.33919 cm} x{2.63781 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Inhibitors of Protein Synthesis- 30S Subunit (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
 & Topical/IV, bacteriocidal, renal clearance \tn 
% Row Count 2 (+ 2)
% Row 6
\SetRowColor{white}
 & {\emph{Side effects}}: possible allergic rxn, diarrhea, n/v, nephrotoxicity, ototoxicity, neuromuscular block, photosensitivity \tn 
% Row Count 8 (+ 6)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Prokaryotes have 70s ribosomes, consisting of a 30s and 50s subunit}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.14011 cm} x{2.83689 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Inhibitors of Protein Synthesis- 50S Subunit}}  \tn
% Row 0
\SetRowColor{LightBackground}
MOA & Bind reversibly to the 50S ribosomal subunit at a position that blocks the binding of the aminoacyl-tRNA to the acceptor site on the mRNA-ribosome complex. Protein synthesis is ultimately inhibited, leading to a bacteriostatic effect \tn 
% Row Count 11 (+ 11)
% Row 1
\SetRowColor{white}
{\bf{Erythromycin}} (Macrolides) & Effective against gm+ except MRSA, few gm- and some anaerobes (no bacteroides) \tn 
% Row Count 15 (+ 4)
% Row 2
\SetRowColor{LightBackground}
 & Bacteriostatic and hepatic clearance \tn 
% Row Count 17 (+ 2)
% Row 3
\SetRowColor{white}
 & {\emph{Side effects}}: possible allergic rxn, diarrhea, n/v, thrombophlebitis, hepatotoxicty, metabolites can inhibit certain cp450 isoenzymes in the liver \& thereby increase conc. of drugs also metabolized by liver enzymes (eg increase in levels of calcium channel blockers) \tn 
% Row Count 30 (+ 13)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{5.377cm}{x{2.14011 cm} x{2.83689 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Inhibitors of Protein Synthesis- 50S Subunit (cont)}}  \tn
% Row 4
\SetRowColor{LightBackground}
{\bf{Clindamycin}} (Lincosamides) & Effective against gm+ including some MRSA, and most anaerobes, including bacteroides; however not effective against c.difficile \tn 
% Row Count 6 (+ 6)
% Row 5
\SetRowColor{white}
 & Bacteriostatic (very close to bacteriocidal), hepatic clearance \tn 
% Row Count 9 (+ 3)
% Row 6
\SetRowColor{LightBackground}
 & good penetration of most tissues, including bone \tn 
% Row Count 12 (+ 3)
% Row 7
\SetRowColor{white}
 & Side effects: Diarrhea \tn 
% Row Count 13 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Cell Wall Synthesis Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Cloxacillin}} {\emph{Penicillinase resistant penicillins}} & 250 or 500 mg, mitte: X tablets,sig: 1 PO every 6h for x days \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
{\bf{Amoxicillin}} {\emph{Aminopenicillins}} & 250 or 500mg, mitte: X tablets, sig: 1 Po every 6-8 hours for x days \tn 
% Row Count 8 (+ 4)
% Row 2
\SetRowColor{LightBackground}
{\bf{Amoxicillin/clavulanate}} {\emph{Penicillin/ B/lactamase inhibitor}} & 250,500,875mg, mitte: x capsules. sig: 1 PO every 8-12h (12 for 875mg) \tn 
% Row Count 12 (+ 4)
% Row 3
\SetRowColor{white}
{\bf{Cephalexin}} {\emph{Cephalosporin}} & 250 or 500mg, mitte: X tablets, sig: 1 PO  every 6h for X days \tn 
% Row Count 16 (+ 4)
% Row 4
\SetRowColor{LightBackground}
{\bf{Cefadroxil}} {\emph{Cephalosporins}} & 500mg, mite: x capsules, sig: 1 PO every 12h for x days \tn 
% Row Count 19 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.28942 cm} x{2.68758 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Protein Synthesis Inhibitor}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Clindamycin}} {\emph{Lincosamides}} & 150 or 300mg, mitte: X capsules, sig: one PO every 6-8 hours for X days \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
{\bf{Erythromycin}} {\emph{Macrolides}} & 250 or 500mg, mitte: X tablets, sig: 1 PO  every 6h for X days \tn 
% Row Count 7 (+ 3)
% Row 2
\SetRowColor{LightBackground}
{\bf{Azithromycin}} {\emph{Macrolides}} & 250mg, mitte: 6 tablets, sig: day 1- 2 tablets once PO, days 2-5: 1 tablet PO daily \tn 
% Row Count 11 (+ 4)
% Row 3
\SetRowColor{white}
{\bf{Tetracyclines}} {\emph{(30S subunit) }} & 250 or 500mg, mitte: X tablets, sig: 1 PO every 6h for X days \tn 
% Row Count 14 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.4885 cm} x{2.4885 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Folate Antagonists}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Sulfamethoxazole/trimethoprim}} {\emph{ Sulfonamides/trimethoprim}} & 800/160mg tablets, mitte: X tablets, sig: 1 PO every 12h for X days \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
{\bf{Ciprofloxacin}} {\emph{Quinolones}} & 250,500,750mg mitte: X tablets, sig: 1 PO every 12H \tn 
% Row Count 7 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}