\documentclass[10pt,a4paper]{article}

% Packages
\usepackage{fancyhdr}           % For header and footer
\usepackage{multicol}           % Allows multicols in tables
\usepackage{tabularx}           % Intelligent column widths
\usepackage{tabulary}           % Used in header and footer
\usepackage{hhline}             % Border under tables
\usepackage{graphicx}           % For images
\usepackage{xcolor}             % For hex colours
%\usepackage[utf8x]{inputenc}    % For unicode character support
\usepackage[T1]{fontenc}        % Without this we get weird character replacements
\usepackage{colortbl}           % For coloured tables
\usepackage{setspace}           % For line height
\usepackage{lastpage}           % Needed for total page number
\usepackage{seqsplit}           % Splits long words.
%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
\usepackage{wasysym}            % Symbols
%\usepackage[english,german,french,spanish,italian]{babel}              % Languages

% Document Info
\author{gwenw}
\pdfinfo{
  /Title (pharmacology-2.pdf)
  /Creator (Cheatography)
  /Author (gwenw)
  /Subject (Pharmacology 2 Cheat Sheet)
}

% Lengths and widths
\addtolength{\textwidth}{6cm}
\addtolength{\textheight}{-1cm}
\addtolength{\hoffset}{-3cm}
\addtolength{\voffset}{-2cm}
\setlength{\tabcolsep}{0.2cm} % Space between columns
\setlength{\headsep}{-12pt} % Reduce space between header and content
\setlength{\headheight}{85pt} % If less, LaTeX automatically increases it
\renewcommand{\footrulewidth}{0pt} % Remove footer line
\renewcommand{\headrulewidth}{0pt} % Remove header line
\renewcommand{\seqinsert}{\ifmmode\allowbreak\else\-\fi} % Hyphens in seqsplit
% This two commands together give roughly
% the right line height in the tables
\renewcommand{\arraystretch}{1.3}
\onehalfspacing

% Commands
\newcommand{\SetRowColor}[1]{\noalign{\gdef\RowColorName{#1}}\rowcolor{\RowColorName}} % Shortcut for row colour
\newcommand{\mymulticolumn}[3]{\multicolumn{#1}{>{\columncolor{\RowColorName}}#2}{#3}} % For coloured multi-cols
\newcolumntype{x}[1]{>{\raggedright}p{#1}} % New column types for ragged-right paragraph columns
\newcommand{\tn}{\tabularnewline} % Required as custom column type in use

% Font and Colours
\definecolor{HeadBackground}{HTML}{333333}
\definecolor{FootBackground}{HTML}{666666}
\definecolor{TextColor}{HTML}{333333}
\definecolor{DarkBackground}{HTML}{A3A3A3}
\definecolor{LightBackground}{HTML}{F3F3F3}
\renewcommand{\familydefault}{\sfdefault}
\color{TextColor}

% Header and Footer
\pagestyle{fancy}
\fancyhead{} % Set header to blank
\fancyfoot{} % Set footer to blank
\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
    }
\end{tabulary}
\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Pharmacology 2 Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{gwenw} via \textcolor{DarkBackground}{\uline{cheatography.com/63534/cs/16148/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}gwenw \\
  \uline{cheatography.com/gwenw} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 21st June, 2018.\\
   Updated 22nd June, 2018.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
  \SetRowColor{white}
  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{x{0.91894 cm} p{0.45947 cm} p{0.45947 cm} x{2.33912 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{5.377cm}}{\bf\textcolor{white}{Insulin}}  \tn
% Row 0
\SetRowColor{LightBackground}
Lispro, Aspart & \seqsplit{Regular} & NPH & Glargine, Detemir, Degludec (basal) \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
O:\textless{}15 m & \seqsplit{O:.5-1} & O:2-4 & O:2-4 \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
P:1-2 & P:2-3 & \seqsplit{P:4-10} & P:N/A \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
D: 3-4 & D:3-6 & \seqsplit{D:10-16} & D:24 \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.84149 cm} x{3.13551 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Tofacitinib}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Janus kinas inhibitor PO} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
2x/day reduced to 1x if & Potent CYP3A4 and CYP2c19 inhibitors (e.g. fluconazole) \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & Severe renal impairment \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
 & Mod liver impairment \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Combined w/methotrexate or nonbio DMARD} \tn 
% Row Count 7 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{DO NOT combine w/bio DMARD} \tn 
% Row Count 8 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Other DMARDs in Refractory RA}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Azathioprine, Cyclophosphamide, Cyclosporine, Penicillamine} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Last-line therapy in refractory disease} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{use is limited by higher rates of adverse effects} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anaesthetics SE}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{CNS effects \newline % Row Count 1 (+ 1)
Reduction of vascular resistance \newline % Row Count 2 (+ 1)
Increased intracranial pressure \newline % Row Count 3 (+ 1)
Decrease BP \newline % Row Count 4 (+ 1)
Entrorane and Halothane decrease CO \newline % Row Count 5 (+ 1)
Decreased blood flow to liver and kidneys \newline % Row Count 6 (+ 1)
Decrease respiratory rate \newline % Row Count 7 (+ 1)
Malignant hyperthermia (uncontrolled Ca release) \newline % Row Count 8 (+ 1)
Treated with dantrolene% Row Count 9 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.64241 cm} x{3.33459 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Local Anesthetics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Intermediate chain linking amino to aromatic ring} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{block Na+ channels in nerve} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{sympathetic → sharp/dull → touch/temp → motor paralysis} \tn 
% Row Count 4 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{More effect on small C fibers and small A fibers} \tn 
% Row Count 5 (+ 1)
% Row 4
\SetRowColor{LightBackground}
Amino Esters & Surface: Benzocaine, cocaine \tn 
% Row Count 7 (+ 2)
% Row 5
\SetRowColor{white}
 & Short: Procaine \tn 
% Row Count 8 (+ 1)
% Row 6
\SetRowColor{LightBackground}
 & Long: Tetracaine \tn 
% Row Count 9 (+ 1)
% Row 7
\SetRowColor{white}
Amino Acids & Medium: Lidocaine \tn 
% Row Count 10 (+ 1)
% Row 8
\SetRowColor{LightBackground}
 & Long: Bupivacaine, ropivacaine \tn 
% Row Count 12 (+ 2)
% Row 9
\SetRowColor{white}
Lidocaine Patch & 12hr on/12 off \tn 
% Row Count 14 (+ 2)
% Row 10
\SetRowColor{LightBackground}
 & 3 patch max \tn 
% Row Count 15 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.4931 cm} x{3.4839 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Opioids}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Act on Mu, Kappa, Delta receptors} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\seqsplit{Phenanthrenes} & (natural) Codeine, Morphine \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Phenanthrenes} & (semisynthetic) Hydrocodone, Hydromorphone, Oxycodone \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
\seqsplit{Phenylpiperidines} & Fentanyl, Meperidine (chills) \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\seqsplit{Phenylethylamines} & Methadone, Propoxyphene \tn 
% Row Count 9 (+ 2)
% Row 5
\SetRowColor{white}
Extended & Oxycodone, Morphine, Fentanyl \tn 
% Row Count 11 (+ 2)
% Row 6
\SetRowColor{LightBackground}
Tramadol & Mu receptor agonist, inhibit serotonin and NE reuptake \tn 
% Row Count 13 (+ 2)
% Row 7
\SetRowColor{white}
 & Mild to moderate pain \tn 
% Row Count 14 (+ 1)
% Row 8
\SetRowColor{LightBackground}
 & SE: ↓resp depression than other opioids, sedation, constipation, dry mouth, nausea, serotonin tox \tn 
% Row Count 18 (+ 4)
% Row 9
\SetRowColor{white}
Morphine & Controlled or immediate \tn 
% Row Count 19 (+ 1)
% Row 10
\SetRowColor{LightBackground}
 & SE: potential accumulation, itch \tn 
% Row Count 21 (+ 2)
% Row 11
\SetRowColor{white}
 & Not indicated in pts w/renal \tn 
% Row Count 22 (+ 1)
% Row 12
\SetRowColor{LightBackground}
Oxycodone & High oral bioavailability w/no food effect \tn 
% Row Count 24 (+ 2)
% Row 13
\SetRowColor{white}
 & No significant metabolites \tn 
% Row Count 25 (+ 1)
% Row 14
\SetRowColor{LightBackground}
 & minimally affected by age renal or liver \tn 
% Row Count 27 (+ 2)
% Row 15
\SetRowColor{white}
Methadone & alpha 8-12, beta 24-36 \tn 
% Row Count 28 (+ 1)
% Row 16
\SetRowColor{LightBackground}
 & NMDA receptor antagonist/ Serotonergic properties \tn 
% Row Count 30 (+ 2)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{5.377cm}{x{1.4931 cm} x{3.4839 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Opioids (cont)}}  \tn
% Row 17
\SetRowColor{LightBackground}
 & SE: Toxicity, QTc prolongation \tn 
% Row Count 2 (+ 2)
% Row 18
\SetRowColor{white}
Meperidine & Causes euphoria, most addictive, seizures \tn 
% Row Count 4 (+ 2)
% Row 19
\SetRowColor{LightBackground}
Agonists & Oxycodone, Codeine, Hydrocodone \tn 
% Row Count 6 (+ 2)
% Row 20
\SetRowColor{white}
Mixed & Buprenorphine \tn 
% Row Count 7 (+ 1)
% Row 21
\SetRowColor{LightBackground}
Antagonists & Naltrexone, Naloxone \tn 
% Row Count 8 (+ 1)
% Row 22
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{SE: CNS/resp depression (5-7 days), N/V (codeine), constipation, itch/rash} \tn 
% Row Count 10 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.18988 cm} x{2.78712 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Lipid Lowering Drugs}}  \tn
% Row 0
\SetRowColor{LightBackground}
HMG- CoA reductase inhibitors & E.g. Atorvastatin, Rosuvastatin, red rice yeast \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
 & Primary agents \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & ↓ LDL and TG, ↑ HDL, ↓ morbidity/mortality \tn 
% Row Count 7 (+ 3)
% Row 3
\SetRowColor{white}
 & antithrombotic effects,  ↓endothelial inflammation \tn 
% Row Count 10 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & SE: myopathy and hepatotox, elevated LFTs, CPK (muscle/jt pain, rhabdo), proximal muscle weakness \tn 
% Row Count 15 (+ 5)
% Row 5
\SetRowColor{white}
 & CYP450 (grapefruit, Cimetidine) \tn 
% Row Count 17 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & Memory loss, diabetes \tn 
% Row Count 18 (+ 1)
% Row 7
\SetRowColor{white}
Bile acid sequestrants (resins) & E.g. Cholestyramine;  ↓ LDL, ↑HDL and TG; Unpleasant taste, GI effects, intxns; Other meds 1 hr before or 4 hr after \tn 
% Row Count 24 (+ 6)
% Row 8
\SetRowColor{LightBackground}
Fibrates & E.g. Gemfibrozil, fenofibrate \tn 
% Row Count 26 (+ 2)
% Row 9
\SetRowColor{white}
 & ↓ LDL and TG, ↑ HDL \tn 
% Row Count 28 (+ 2)
% Row 10
\SetRowColor{LightBackground}
 & Toxicity additive w/statins \tn 
% Row Count 30 (+ 2)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{5.377cm}{x{2.18988 cm} x{2.78712 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Lipid Lowering Drugs (cont)}}  \tn
% Row 11
\SetRowColor{LightBackground}
 & Rhabdo, myopathy, LDL increase \tn 
% Row Count 2 (+ 2)
% Row 12
\SetRowColor{white}
Nicotinic Acid & ↓ LDL and TG, ↑ HDL \tn 
% Row Count 4 (+ 2)
% Row 13
\SetRowColor{LightBackground}
 & Flushing, itching, HA, Hyperuricemia in gout, Hyperglycemia, Hepatotox \tn 
% Row Count 8 (+ 4)
% Row 14
\SetRowColor{white}
Chol absorption inhibit & E.g. Ezetimibe \tn 
% Row Count 10 (+ 2)
% Row 15
\SetRowColor{LightBackground}
 & Decrease LDL, increase HDL \tn 
% Row Count 12 (+ 2)
% Row 16
\SetRowColor{white}
 & HA Diarrhea Upper resp infection \tn 
% Row Count 14 (+ 2)
% Row 17
\SetRowColor{LightBackground}
 & hepatotox + rhabdo with statins \tn 
% Row Count 16 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Acetaminophen}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{central COX inhibitor} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Analgesic \& Antipyretic} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{NOT anti-inflammatory or antithrombotic} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{SE: Hepatotoxicity} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{1st line for OA} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Avoid alcohol} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{No Raye's syndrome} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Similar to NSAIDs, better tolerated} \tn 
% Row Count 8 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{2 wks before considering treatment failure} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{GLP-1 Agonist}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{E.g. Exenatide, Liraglutide} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↑ insulin release} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{↓A1C \textasciitilde{}0.7} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{SE: GI upset, weight loss} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Maybe pancreatitis, gallbladder disease, thyroid cancer} \tn 
% Row Count 6 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Caution in renal disease} \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{CV benefit} \tn 
% Row Count 8 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.14471 cm} x{3.83229 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Anti-Factor Xa Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Fondaparinux} & SC treat/prevent DVT/PE \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Avoid use in Crcl \textless{}30 ml/min \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & Monitor: Anti-Xa, sx of bleeding \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
Apixaban & Inhibit factor X \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
 & adjust in Afib if ⅔ \textgreater{}80 yo, Scr \textgreater{}1.5, weight \textless{}60kg \tn 
% Row Count 8 (+ 2)
% Row 5
\SetRowColor{white}
 & Intxns: phenytoin, carbamazepine, fluconazole, rifampin \tn 
% Row Count 10 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & bleeding, compliance \tn 
% Row Count 11 (+ 1)
% Row 7
\SetRowColor{white}
\seqsplit{Rivaroxaban} & inhibit factor X \tn 
% Row Count 13 (+ 2)
% Row 8
\SetRowColor{LightBackground}
 & Take w/evening meal \tn 
% Row Count 14 (+ 1)
% Row 9
\SetRowColor{white}
 & Intxns: phenytoin, carbamazepine, fluconazole, rifampin \tn 
% Row Count 16 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Thiazolidinediones}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{E.g. Pioglitazone, Rosiglitazone (not used, ↑CVD)} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↓HDL, triglycerides; neutral LDL} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Decrease fasting plasma glucose 35-40} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Reduce A1C \textasciitilde{}0.5-1\%} \tn 
% Row Count 5 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{6 weeks for max effect} \tn 
% Row Count 6 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{SE: weight ↑, edema, hypoglycemia} \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Contraindicated liver problems or CHF} \tn 
% Row Count 8 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.54287 cm} x{3.43413 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Reversal of anticoagulation}}  \tn
% Row 0
\SetRowColor{LightBackground}
Warfarin & Vitamin K \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Keparin & Protamine \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
Enoxaparin & Protamine (less reliable) \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
Dabigatran & Idarucizumab \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
Apixaban & zhzo Xa \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
Rivaroxaban & zhzo Xa \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.74655 cm} x{4.23045 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Statin Monitoring}}  \tn
% Row 0
\SetRowColor{LightBackground}
CK & Baseline: only in pts at increased risk for musc injury \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Routine: only in pts w/musc pain/weakness \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
ALT & Routine: only if symptoms of hepatotox occur \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
FLP & Routine: 4-12 wks after initiation, then Q3-12 months as indicated \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Hgb A1c & Baseline: only if diabetes status unknown \tn 
% Row Count 10 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.04057 cm} x{2.93643 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Anticoagulants}}  \tn
% Row 0
\SetRowColor{LightBackground}
Heparin & Unfractionated heparin (UFH); IV/SC \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & monitor aPTT, platelets, hgb, hct, HIT \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Low-molecular-weight} heparin & Enoxaparin, SC \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
 & Renal adjust Crcl \textless{}30 \tn 
% Row Count 7 (+ 1)
% Row 4
\SetRowColor{LightBackground}
 & monitor less frqnt, Anti-Xa levels not aPTT \tn 
% Row Count 9 (+ 2)
% Row 5
\SetRowColor{white}
Anti-Factor Xa inhibitor & Fondaparinux, SC \tn 
% Row Count 11 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & Apixaban, PO \tn 
% Row Count 12 (+ 1)
% Row 7
\SetRowColor{white}
 & Rivaroxaban, PO \tn 
% Row Count 13 (+ 1)
% Row 8
\SetRowColor{LightBackground}
Direct Thrombin Inhibitors & Argatroban, IV \tn 
% Row Count 15 (+ 2)
% Row 9
\SetRowColor{white}
 & Dabigatran, PO \tn 
% Row Count 16 (+ 1)
% Row 10
\SetRowColor{LightBackground}
Vitamin K antag & Warfarin, PO \tn 
% Row Count 17 (+ 1)
% Row 11
\SetRowColor{white}
 & Onset: slow, anticoagulation occurs 48-72 h after the first dose once factors are depleted \tn 
% Row Count 21 (+ 4)
% Row 12
\SetRowColor{LightBackground}
 & Monitor INR (goal 2-3), Hgb/hct,  bleeding \tn 
% Row Count 23 (+ 2)
% Row 13
\SetRowColor{white}
 & Intxn: Food: green leafy vegetables Meds: cipro, bactrim, flagyl, fluconazole, rifampin \tn 
% Row Count 27 (+ 4)
% Row 14
\SetRowColor{LightBackground}
 & Preferred in renal dysfunction \tn 
% Row Count 29 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Local Anesthetics Additives}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Vasodilation prevented by vasoconstrictor (e.g. epinephrine); prolong effect/decrease dose -{}- do not use in fingers/toes} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Bicarbonate Decrease burning sensation during admin} \tn 
% Row Count 5 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{0.9954 cm} x{3.9816 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Direct Thrombin Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Do not require antithrombin} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Monitor aPTT, platelets, hgb, het, bleeding} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Continuous infusions} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Used in HIT mgmt} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Short duration} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\seqsplit{Argatroban} & Falsely elevate INR \tn 
% Row Count 7 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & No monitoring or reversal agent \tn 
% Row Count 8 (+ 1)
% Row 7
\SetRowColor{white}
 & ADE: upset stomach, bleed \tn 
% Row Count 9 (+ 1)
% Row 8
\SetRowColor{LightBackground}
 & Intxns: avoid rifampin \tn 
% Row Count 10 (+ 1)
% Row 9
\SetRowColor{white}
 & Store in original container and use within 30 days of opening \tn 
% Row Count 12 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.59264 cm} x{3.38436 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{IV Anesthetics}}  \tn
% Row 0
\SetRowColor{LightBackground}
Etomidate & Hypnotic \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
 & Rapid onset gen anesthesia \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & Min cardiopulm SE \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
 & Good for CV and pulm comorbid \tn 
% Row Count 5 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Propofol & Short acting hypnotic \tn 
% Row Count 6 (+ 1)
% Row 5
\SetRowColor{white}
 & Very rapid recovery \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
Thiopental sodium & Respiratory depressant, no analgesia \tn 
% Row Count 9 (+ 2)
% Row 7
\SetRowColor{white}
 & Rapid safe induction \tn 
% Row Count 10 (+ 1)
% Row 8
\SetRowColor{LightBackground}
 & Barbiturate \tn 
% Row Count 11 (+ 1)
% Row 9
\SetRowColor{white}
Midazolam & Benzodiazepine \tn 
% Row Count 12 (+ 1)
% Row 10
\SetRowColor{LightBackground}
 & Amnesia \tn 
% Row Count 13 (+ 1)
% Row 11
\SetRowColor{white}
 & Potentially long halflife \tn 
% Row Count 14 (+ 1)
% Row 12
\SetRowColor{LightBackground}
Ketamine & Dissociative analgesia \tn 
% Row Count 15 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Anticoagulant Dosing}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{DVT ppx: enoxparin 40mg q24 or 30mg q12 or heparin  5k units bid-tid. \newline % Row Count 2 (+ 2)
PE/DVT tx: Enoxaparin 1.5mg/kg q24 hrs and 1mg/kg q12 hrs; heparin drip 18 units/kg/hr% Row Count 4 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.54287 cm} x{3.43413 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Non-Bio DMARDs}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{RA w/in 3 mo, max 6-12 mo} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{LF, HCQ, MTX need blood count, liver, Cr every 2-4wk/3mo then every 8-12 wks} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Methotrexate} & 1st line, 2-8 wk onset PO/IM immunosuppressant \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
 & SE: GI, liver tox, bone marrow, stomatitis, hair loss, pulm tox \tn 
% Row Count 8 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & Folic acid decrease sx \tn 
% Row Count 9 (+ 1)
% Row 5
\SetRowColor{white}
Leflunomide & Immunosuppressant effective as MTX \tn 
% Row Count 11 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & SE: GI, rash, hair loss, liver tox \tn 
% Row Count 13 (+ 2)
% Row 7
\SetRowColor{white}
 & Work w/in 1 mo, weaker \tn 
% Row Count 14 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\seqsplit{Hydroxychloroquine} & Low tox, 2-6 mo onset, min monitor \tn 
% Row Count 16 (+ 2)
% Row 9
\SetRowColor{white}
 & SE: GI, retinal, derm, HA \tn 
% Row Count 17 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\seqsplit{Sulfasalazine} & 2-3x/day PO anti-inflam \tn 
% Row Count 19 (+ 2)
% Row 11
\SetRowColor{white}
 & SE: GI, leukopenia, anemia, photosensitive, skin, hepatitis, pneumonitis, agranulocytosis, hypersensitivity \tn 
% Row Count 23 (+ 4)
% Row 12
\SetRowColor{LightBackground}
 & \textgreater{}HCQ, \textless{}DMARDs \tn 
% Row Count 24 (+ 1)
% Row 13
\SetRowColor{white}
 & poor tolerate, lots of monitoring \tn 
% Row Count 26 (+ 2)
% Row 14
\SetRowColor{LightBackground}
 & Potentiate anticoagulants \tn 
% Row Count 27 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.89126 cm} x{3.08574 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Non-Opioid Analgesics}}  \tn
% Row 0
\SetRowColor{LightBackground}
NSAIDs, ASA, salicylates & Prostaglandin inhibitors \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Inhibit COX-1 and COX-2 \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & GI side effects \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
 & ASA = antiplatelet primarily used to prevent heart disease and stroke \tn 
% Row Count 7 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & Thromboxanes involved in platelet aggregation and thrombus formation \tn 
% Row Count 10 (+ 3)
% Row 5
\SetRowColor{white}
Selective COX-2 inhibitor & e.g. Celecoxib \tn 
% Row Count 12 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & ↑ MI and stroke \tn 
% Row Count 13 (+ 1)
% Row 7
\SetRowColor{white}
 & Rofecoxib and Valdecoxib taken off market \tn 
% Row Count 15 (+ 2)
% Row 8
\SetRowColor{LightBackground}
 & Celecoxib ↓GI SE in pt not on ASA \tn 
% Row Count 17 (+ 2)
% Row 9
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Do not cause tolerance, not addictive} \tn 
% Row Count 18 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{All have ceiling effect to analgesia} \tn 
% Row Count 19 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Biguanides}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{e.g. metformin} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↓ glucose product, ↑ glucose uptake} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{↓ A1C 1-1.5} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Low risk hypoglycemia} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{SE: Diarrhea/GI, ↓B12, l. acidosis, weight ↓} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Contraindicated GFR\textless{}30} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Meglitinides}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{e.g. Repaglinide, Nateglinide} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Stimulate insulin secretion} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Shorter acting, best taken after eating} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↓A1C \textasciitilde{}1} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{SE: Hypoglycemia, weight ↑} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Safe w/greater renal insufficiency than SU} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{SGLT2 Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{E.g. Canagliflozin, Empagliflozin} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↑glucose excretion} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{↓A1C 0.7-1} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Empagliflozin: avoid if GFR \textless{}45} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{SE: Genital fungal infxn, UTI, AKI, dizzy, hypotension, hyperkalemia, hypoglycemia, fractures, ↓BMD, CV benefits} \tn 
% Row Count 7 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Opioid Withdrawal}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Body aches, weakness, fatigue \newline % Row Count 1 (+ 1)
Diarrhea, stomach cramping \newline % Row Count 2 (+ 1)
Insomnia \newline % Row Count 3 (+ 1)
Irritability \newline % Row Count 4 (+ 1)
Loss of appetite \newline % Row Count 5 (+ 1)
Nausea/vomiting  \newline % Row Count 6 (+ 1)
Increased BP/HR \newline % Row Count 7 (+ 1)
Runny nose, sneezing, yawning \newline % Row Count 8 (+ 1)
Chilliness and "goose bumps"% Row Count 9 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Patient Controlled Analgesia}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{e.g. Morphine, hydromorphone} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Monitor HR, BP, RR, Pain, usage, O2} \tn 
% Row Count 2 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Capsaicin Cream}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Inhibits release of substance P in peripheral} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Max effect takes 2-4 wks application 4x/day} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{More role in OA than RA} \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Viscosupplimentation}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{E.g. hyaluronic acid} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{lubricant during low-stress mvmt, anti inflam} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Has more role in OA than RA, esp knee} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{3-5 wkly injections = 1 cycle} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Max effect 8-12 wks, lasts 6-12 mo} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.09494 cm} x{3.88206 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Bio DMARDs}}  \tn
% Row 0
\SetRowColor{LightBackground}
Non-TNF & Abatacept SE: Pulmonary infection, allergic rxn, HA/dizzy \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Anakinra SE: inj site rxn, infection, allergic rxn \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & Rituximab SE: rash, infection, neuro, infusion rxn, Tumor Lysis, multifocal leukoencephalopathy \tn 
% Row Count 8 (+ 4)
% Row 3
\SetRowColor{white}
TNF inhibit & Adalimumab: SC every 2 wk, mild-mod inject rxn \tn 
% Row Count 10 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Etanercept: SC 1-2/wk, mild-mod inject rxn \tn 
% Row Count 12 (+ 2)
% Row 5
\SetRowColor{white}
 & Infliximab: IV at 0,2,6,8 wk; infusion rxn \tn 
% Row Count 14 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & Increased malignancy risk \tn 
% Row Count 15 (+ 1)
% Row 7
\SetRowColor{white}
 & SE: hypersensitivity, Lupus-like, hepatotox, pancytopenia, aplastic anemia, heart failure \tn 
% Row Count 18 (+ 3)
% Row 8
\SetRowColor{LightBackground}
 & MTX combo or solo \tn 
% Row Count 19 (+ 1)
% Row 9
\SetRowColor{white}
 & Mod-severe RA \tn 
% Row Count 20 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Possibly reactivates TB, no live vaccine} \tn 
% Row Count 21 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Sulfonylurea}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{e.g. Glyburide, Glimepiride, Glipizide} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↑endogenous insulin secretion} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{↓A1C 1-2} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{SE: hypoglycemia, ↑weight, photosensitive} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Least expensive} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Caution in renal, elderly} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Often discontinued once insulin started} \tn 
% Row Count 7 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.09494 cm} x{3.88206 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{ADP Receptor Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Clopidogrel} & Indications: ASA + Clopidogrel in pts receiving stents \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{Prasugrel} & More potent, less variable platelet response than Clopidogrel \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & reduction of thrombotic CV events (including stent thrombosis) in pts w/ACS who are to be managed w/PCI \tn 
% Row Count 8 (+ 4)
% Row 3
\SetRowColor{white}
 & Risks may exceed benefits in pts w/ \textgreater{}75 yo Previous history of TIA or stroke \textless{}60kg \tn 
% Row Count 11 (+ 3)
% Row 4
\SetRowColor{LightBackground}
 & Likely to undergo CABG = bleed risk \tn 
% Row Count 13 (+ 2)
% Row 5
\SetRowColor{white}
 & Hold for 7 days before surgery \tn 
% Row Count 14 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\seqsplit{Ticagrelor} & SE: bleeding, dyspnea, bradycardia \tn 
% Row Count 16 (+ 2)
% Row 7
\SetRowColor{white}
 & 2x/day \tn 
% Row Count 17 (+ 1)
% Row 8
\SetRowColor{LightBackground}
 & Avoid in pts w/hx of hemorrhagic stroke \tn 
% Row Count 19 (+ 2)
% Row 9
\SetRowColor{white}
 & Avoid aspirin \textgreater{}100 mg CYP 3a4 inducers (rifampin, carbamazepine, phenytoin) CYP 3A4 inhibitors (ketoconazole, ritonavir) Monitor digoxin levels \tn 
% Row Count 24 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.4931 cm} x{3.4839 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Glucosamine/Chondroitin}}  \tn
% Row 0
\SetRowColor{LightBackground}
Glucosamine & cartilage building block \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Chondroitin & Increase protein synthesis \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{OTC, not 1st line, may improve OA knee pain} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Weeks to months for effect} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{SE: GI upset} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{DPP-4 inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{e.g. Sitagliptin, Saxagliptin} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{↑ incretin, insulin release} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{↓A1C \textasciitilde{}0.7} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Well tolerated, no weight gain, no hypoglycemia} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Maybe pancreatitis, jt pain, heart failure} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Dose modification in renal impairment} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{CYP3a4 interactions} \tn 
% Row Count 7 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.64701 cm} x{4.32999 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Heparin Induced Thrombocytopenia}}  \tn
% Row 0
\SetRowColor{LightBackground}
Type 1 & 10-20\% \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Onset: 2-3 d \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
 & Platelet \textless{}50\% decrease, nadir \textgreater{}100k \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
Type 2 & 1-3\% \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Onset: 5-10 d \tn 
% Row Count 8 (+ 1)
% Row 5
\SetRowColor{white}
 & Platelet \textgreater{}50\% decrease, nadir 10-20k \tn 
% Row Count 10 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & Antibody mediated \tn 
% Row Count 11 (+ 1)
% Row 7
\SetRowColor{white}
 & Thromboembolic sequelae 30-80\% \tn 
% Row Count 12 (+ 1)
% Row 8
\SetRowColor{LightBackground}
 & D/c all heparin products, initiate direct thrombin inhibitor/coumadin \tn 
% Row Count 15 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Thrombolytics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Alteplase (IV)} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Dissolve clots acutely/clear IV line} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Relative contraindication: HTN} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Absolute contraindication: recent head trauma} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{ADR: bleeding, hemorrhage} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{C} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Antiplatelets}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Aspirin} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{ADP receptor inhibitors e.g. Clopidogrel Prasugrel Ticagrelor} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{PO} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{monoclonal antibodies/PCSK9 inhibit}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{SC \newline % Row Count 1 (+ 1)
Reduce LDL by additional 60\% with statin \newline % Row Count 2 (+ 1)
E.g. evolocumab, alirocumab \newline % Row Count 3 (+ 1)
Advantages: injected once or twice/month \newline % Row Count 4 (+ 1)
SE: common cold, itching, flu, injxn site rxns, allergic rxns% Row Count 6 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{2.04057 cm} x{2.93643 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Other Antidiabetics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Alpha-glucosidase} inhibitors & e.g. Acarbose \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & block enzymes that digest starches in small intestine \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & GI upset, flatulence, bloating \tn 
% Row Count 7 (+ 2)
% Row 3
\SetRowColor{white}
Amylin analogs & e.g. Pramlintide \tn 
% Row Count 8 (+ 1)
% Row 4
\SetRowColor{LightBackground}
 & Injectable \tn 
% Row Count 9 (+ 1)
% Row 5
\SetRowColor{white}
Bile acid sequestrants & e.g. Colesevelam \tn 
% Row Count 11 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & GI side effects \tn 
% Row Count 12 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.64241 cm} x{3.33459 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Corticosteroids}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{E.g. Dexamethasone, Hydrocortisone, Methylprednisolone} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{Intraarticular} & 1-6 wk relief for OA/RA knee \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & 3-4/yr limit \tn 
% Row Count 5 (+ 1)
% Row 3
\SetRowColor{white}
 & Lidocaine sometimes added \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
Systemic & RA, not OA \tn 
% Row Count 7 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Acute SE: Hyperglycemia, HTN, euphoria/psychosis, weight↑/edema, GI bleed} \tn 
% Row Count 9 (+ 2)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Chronic SE: Cushing's appearance, cataracts, hyperlipidemia, muscle/tendon, OP/fractures, infection, HPA suppression} \tn 
% Row Count 12 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.14471 cm} x{3.83229 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{NSAIDs}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{1st line in RA, 2nd in OA} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Aspirin & Most widely used, analgesic, antinflammatory, antipyretic, antiplatelet \tn 
% Row Count 4 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Diclofenac} & more potent than other NSAIDs, ADRs occur in 20\% \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
\seqsplit{Ibuprofen} & fever, GI side effects \textasciitilde{}5-15\% \tn 
% Row Count 7 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\seqsplit{Indomethacin} & Dose related side effects (i.e. confusion); 35-50\% pts \tn 
% Row Count 9 (+ 2)
% Row 5
\SetRowColor{white}
\seqsplit{Ketorolac} & Orally or IM, IV doses provide postoperative analgesia equivalent to opioids \tn 
% Row Count 12 (+ 3)
% Row 6
\SetRowColor{LightBackground}
 & not used  \textgreater{}5 days due to ADR \tn 
% Row Count 13 (+ 1)
% Row 7
\SetRowColor{white}
Naproxen & Similar to ibuprofen, less frequent dosing 2x/day \tn 
% Row Count 15 (+ 2)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{SE: GI, acute renal failure, BP, hypersensitivity} \tn 
% Row Count 16 (+ 1)
% Row 9
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{GI SE: Celecoxib \textless{} Diclofenac \textless{} Ibuprofen \& Naproxen \textless{} ketorolac} \tn 
% Row Count 18 (+ 2)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Take ibuprofen at least 2 hours after ASA -{}- makes aspirin ineffective} \tn 
% Row Count 20 (+ 2)
% Row 11
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{GI ulcers/bleed prophylaxis: Misoprostol, Proton pump inhibitors (pantoprazole), H2RAs (ranitidine)} \tn 
% Row Count 22 (+ 2)
% Row 12
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Use with caution on pt on anticoagulants} \tn 
% Row Count 23 (+ 1)
% Row 13
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{Need to take continuously for antiinflam} \tn 
% Row Count 24 (+ 1)
% Row 14
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{2-4 wk trial needed} \tn 
% Row Count 25 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Lidocaine Patch}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{12 hr on/12 hr off} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{3 at at time max} \tn 
% Row Count 2 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{p{0.4977 cm} p{0.4977 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{Anaesthetics Pharmacokinetics}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{highly lipid soluble} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{2}{x{5.377cm}}{When discontinued, drugs will continue to enter systemic circulation} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{5.377cm}}{Lethargy, confusion} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{x{1.44333 cm} x{3.53367 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{5.377cm}}{\bf\textcolor{white}{NM Blocking Agents}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Non-Depolarizing} & Competitive Ach antag \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Pancuronium O: 4-6 min D: 120-180 min \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & Rocuronium O: 1-2 min D: 30-60 min \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
\seqsplit{Depolarizing} & Overstimulate receptor \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Succinylcholine O: 1-1.5 min D: 5-8 min \tn 
% Row Count 10 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}