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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
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% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
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% Document Info
\author{darkknightess}
\pdfinfo{
  /Title (innate-immune-protection.pdf)
  /Creator (Cheatography)
  /Author (darkknightess)
  /Subject (innate immune protection Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{innate immune protection Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{darkknightess} via \textcolor{DarkBackground}{\uline{cheatography.com/79985/cs/19339/}}}
\end{tabulary}
\end{multicols}}

\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}darkknightess \\
  \uline{cheatography.com/darkknightess} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 11th April, 2019.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
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% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{4}

\begin{tabularx}{3.833cm}{x{1.02687 cm} p{0.5266 cm} p{0.60559 cm} p{0.47394 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{3.833cm}}{\bf\textcolor{white}{Innate immunity}}  \tn
% Row 0
\SetRowColor{LightBackground}
Key points & \seqsplit{Physical} & Secreted & \seqsplit{Cellular} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Born/same & Skin & \seqsplit{Antibacterial} & Nk cell \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Non specific/fast & GI tract & \seqsplit{Antibodies} & \seqsplit{Phagocytes} \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
Prevent Pathogen entry & \seqsplit{Respiratory} & \seqsplit{Complements} &  \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Induces adaptative & Mucous & \seqsplit{Cytokines} &  \tn 
% Row Count 10 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{p{0.57926 cm} p{0.63192 cm} x{0.92155 cm} p{0.50027 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{3.833cm}}{\bf\textcolor{white}{Goal 1 - PREVENT}}  \tn
% Row 0
\SetRowColor{LightBackground}
Skin & \seqsplit{Respiratoy} & Eyes & GI tract \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{Dry/Thick} & Tightly Packed & Blink/Tear & \seqsplit{Peristalsis} \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Antimicrobial} & Cilia & Lysopzyme & HCl \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
Keratin & Mucus & Microbial competition & Low Ph \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{x{0.86889 cm} p{0.39495 cm} x{0.86889 cm} p{0.50027 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{4}{x{3.833cm}}{\bf\textcolor{white}{Goal 2 - RECOGNISE}}  \tn
% Row 0
\SetRowColor{LightBackground}
PAMP & \seqsplit{Bacteria} &  & PRR \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Highly conserved & \seqsplit{Gram-ve} & Gram+ve & \seqsplit{Collectins} \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Only microbes & LPS & lipoteichoic Acid & TLR \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
Essential to live & Lipid A &  & Nod like \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}----}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Effector mechanism}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Complements} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Phagocytosis} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} NK} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Activation of Adaptive} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Cytokine} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Stages of Phagocytosis}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{1\{\{fa-arrow-right\}\} Chemotaxis \& Adherence of microbes to phagocytes \newline % Row Count 2 (+ 2)
2\{\{fa-arrow-right\}\} Ingestion \newline % Row Count 3 (+ 1)
3\{\{fa-arrow-right\}\} Phagosome formed \newline % Row Count 4 (+ 1)
4\{\{fa-arrow-right\}\} Phagolysomes through fusion \newline % Row Count 5 (+ 1)
5\{\{fa-arrow-right\}\} Residual body/ indigestible material formed \newline % Row Count 7 (+ 2)
6\{\{fa-arrow-right\}\} Discharged waste% Row Count 8 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Killing Mechanism}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{{\bf{Reactive O\textasciicircum{}2\textasciicircum{} (Neutrophil)}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} After Phagocytosis \{\{fa-arrow-up\}\} O\textasciicircum{}2\textasciicircum{} = Respiratory Burst} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} O\textasciicircum{}2\textasciicircum{} Reduced by NADPH = Hydroxyl radical, hypochlorite} \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{Reactive N\textasciicircum{}3\textasciicircum{} (Mcrophage)}}} \tn 
% Row Count 6 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} L-arginine \{\{fa-arrow-right\}\} L-citruline = NO radicals} \tn 
% Row Count 8 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Catalysed by Nitric oxide synthase (iNOS, NOS2), induced by Cytokines and Bac components} \tn 
% Row Count 11 (+ 3)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} {\bf{Damage in bacterial DNA and Membrane}}} \tn 
% Row Count 13 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Complements}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Proteins in B (blood) and TF (tissue fluid)} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Via cascade} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} C3 convertase activates C3} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{x{2.71207 cm} p{0.72093 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{3.833cm}}{\bf\textcolor{white}{Phagocytosis}}  \tn
% Row 0
\SetRowColor{LightBackground}
Monocytes/ Macrophage & \seqsplit{Neutrophil} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
High in GI tract, Lung, Liver, Spleen & Only in B \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Long life & Short life \tn 
% Row Count 6 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Cytokines}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Protein Messenger} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} De/activating} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} \{\{fa-arrow-right\}\} IL(Interleukin)-1} \tn 
% Row Count 4 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\}\{\{fa-arrow-right\}\} IL-6} \tn 
% Row Count 5 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\}\{\{fa-arrow-right\}\} TNF (tumour necrosis factor) α} \tn 
% Row Count 7 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{Chemokines}}} \tn 
% Row Count 8 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Chemoattractant} \tn 
% Row Count 9 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Inflamation- cell adhere to BV \{\{fa-arrow-right\}\} infection site} \tn 
% Row Count 11 (+ 2)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} IL-8, MCP} \tn 
% Row Count 12 (+ 1)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{interferons}}} \tn 
% Row Count 13 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} IFNα \& IFN{\ss} Produced by virus infected cell} \tn 
% Row Count 15 (+ 2)
% Row 11
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-angle-double-right\}\}  Natural killer cell} \tn 
% Row Count 16 (+ 1)
% Row 12
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-angle-double-right\}\} Infected/tumour cells} \tn 
% Row Count 17 (+ 1)
% Row 13
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-angle-double-right\}\} Respond to TNFa, IL-12} \tn 
% Row Count 18 (+ 1)
% Row 14
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-angle-double-right\}\} make TNFγ} \tn 
% Row Count 19 (+ 1)
% Row 15
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-angle-double-right\}\} Upregulate MHC = Activate Macrophage} \tn 
% Row Count 21 (+ 2)
% Row 16
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-angle-double-right\}\} IL-12 - differention of CD4 Th1 cell} \tn 
% Row Count 23 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{PRR}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{Collectins}} \newline % Row Count 1 (+ 1)
In solution \newline % Row Count 2 (+ 1)
2 region: \newline % Row Count 3 (+ 1)
\{\{fa-adjust\}\} Collagen Like \newline % Row Count 4 (+ 1)
Interacts with effector \newline % Row Count 5 (+ 1)
\{\{fa-adjust\}\} Lectin Like \newline % Row Count 6 (+ 1)
Interacts with Sugar on pathogen. E.g Mannose \newline % Row Count 7 (+ 1)
{\bf{NOD like}} \newline % Row Count 8 (+ 1)
In cytoplasm \newline % Row Count 9 (+ 1)
2 type: \newline % Row Count 10 (+ 1)
\{\{fa-adjust\}\} NOD 1 \newline % Row Count 11 (+ 1)
glytamyl diominopimelic \newline % Row Count 12 (+ 1)
\{\{fa-adjust\}\} NOD 2 \newline % Row Count 13 (+ 1)
muramyl dipeptide \newline % Row Count 14 (+ 1)
\{\{fa-play\}\} Gram -ve +ve \newline % Row Count 15 (+ 1)
{\bf{TOLL like}} \newline % Row Count 16 (+ 1)
TLR 1  \newline % Row Count 17 (+ 1)
G +ve \newline % Row Count 18 (+ 1)
Lipopeptide \newline % Row Count 19 (+ 1)
PDG \newline % Row Count 20 (+ 1)
TLR 2 \newline % Row Count 21 (+ 1)
G +ve \newline % Row Count 22 (+ 1)
Mycoplasma \newline % Row Count 23 (+ 1)
TLR 3 \newline % Row Count 24 (+ 1)
RNA virus (ds RNA, Poly:C) \newline % Row Count 25 (+ 1)
TLR 4 \newline % Row Count 26 (+ 1)
G -ve \newline % Row Count 27 (+ 1)
LPS \newline % Row Count 28 (+ 1)
TLR 5 \newline % Row Count 29 (+ 1)
Flagellin \newline % Row Count 30 (+ 1)
} \tn 
\end{tabularx}
\par\addvspace{1.3em}

\vfill
\columnbreak
\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{PRR (cont)}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{TLR 6 \newline % Row Count 1 (+ 1)
Mycoplasma \newline % Row Count 2 (+ 1)
TLR 7-8 \newline % Row Count 3 (+ 1)
RNA virus (ss RNA) \newline % Row Count 4 (+ 1)
TLR 9 \newline % Row Count 5 (+ 1)
Unmenthylated CpG DNA% Row Count 6 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Antigen presenting cell}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Macrophage} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} B-cell} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{3.833cm}}{\{\{fa-arrow-right\}\} Mature Dentritic cell (Activate T cell)} \tn 
% Row Count 4 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{3.833cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{3.833cm}}{\bf\textcolor{white}{Summary}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{3.833cm}}{{\bf{RECOGNISE}} \{\{fa-arrow-right\}\} PRR/ Complement R \newline % Row Count 2 (+ 2)
{\bf{INGEST}} \{\{fa-arrow-right\}\} Phagocytosis/ Opsonisation \newline % Row Count 4 (+ 2)
{\bf{RECRUIT}} \{\{fa-arrow-right\}\} Inflammation/ Cytokines \newline % Row Count 6 (+ 2)
{\bf{RESPONSE SPECIFIC}} \{\{fa-arrow-right\}\} IL\&TNF/ Antigen processing% Row Count 8 (+ 2)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}