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  /Title (patho-unit3-inflammation-and-repair.pdf)
  /Creator (Cheatography)
  /Author (damn)
  /Subject (patho unit3 inflammation and repair Cheat Sheet)
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    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{patho unit3 inflammation and repair Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{damn} via \textcolor{DarkBackground}{\uline{cheatography.com/195477/cs/40963/}}}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}damn \\
  \uline{cheatography.com/damn} \\
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 14th December, 2023.\\
   Page {\thepage} of \pageref{LastPage}.
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  Measure your website readability!\\
  www.readability-score.com
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Acute inflamation}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Vascular response}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. increase blood flow by vasodilation (histamine)+ vascular congestion} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{-\textgreater{} redness, heat} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{2. increase permeability of vessel by retraction and injury} \tn 
% Row Count 6 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{-\textgreater{} edema} \tn 
% Row Count 7 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{3. Lymph flow increase to drain extravascular fluid + secondary inflammation} \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Terminations}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{1. Mediator bursts rapidly due to short half lives e.g. neutrophil} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{2. Trigger stop signals} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- proinflammatory leukotriene to anti-inflammatory lipoxins} \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- release anti-inflammatory cytokines} \tn 
% Row Count 6 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Chemical mediators}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Cell-derived}} & {\bf{Plasma-derived}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
{\bf{1. Vasoactive amines}} & {\bf{1.Complement system}} \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
- Histamine by mast cell & - Inflammation \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
- Serotonin by platelet aggregation & - Opsonisation \& Phagocytosis \tn 
% Row Count 7 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_} & - Cell lysis \tn 
% Row Count 9 (+ 2)
% Row 5
\SetRowColor{white}
{\bf{2. Arachidonic acid metabolites}} & \seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_} \tn 
% Row Count 11 (+ 2)
% Row 6
\SetRowColor{LightBackground}
Both by leukocyte in lipoxygenagse pathway & {\bf{2.Clotting system}} \tn 
% Row Count 14 (+ 3)
% Row 7
\SetRowColor{white}
{\bf{Leukotrienes}} & - Clotting system: induce thrombin formation \tn 
% Row Count 17 (+ 3)
% Row 8
\SetRowColor{LightBackground}
- LTC4,D4,E4: Vasoconstriction, increase vascular permeability & - Kinin system: vasoactive \tn 
% Row Count 21 (+ 4)
% Row 9
\SetRowColor{white}
- Inhibit by LT receptor antagonist & - Complement system \tn 
% Row Count 23 (+ 2)
% Row 10
\SetRowColor{LightBackground}
{\bf{Lipoxins}} & - Fibrinolytic system \tn 
% Row Count 25 (+ 2)
% Row 11
\SetRowColor{white}
- Suppress inflammation & \seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_} \tn 
% Row Count 27 (+ 2)
% Row 12
\SetRowColor{LightBackground}
{\bf{Prostacyclin}} & {\bf{3.Kinins}} \tn 
% Row Count 28 (+ 1)
% Row 13
\SetRowColor{white}
- PGI2, PDI2, PEI2: Vasodilation & - form bradykinin \tn 
% Row Count 30 (+ 2)
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\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
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\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Chemical mediators (cont)}}  \tn
% Row 14
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\seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_} & a. increase vascular permeability \tn 
% Row Count 2 (+ 2)
% Row 15
\SetRowColor{white}
{\bf{3.Cytokines\& chemokines}} & b. non-vascular smooth muscle contraction \tn 
% Row Count 5 (+ 3)
% Row 16
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{\bf{Cytokines}} & c. pain \tn 
% Row Count 6 (+ 1)
% Row 17
\SetRowColor{white}
- Tumor necrosis factor (TNF) \& interleukin-1 (IL-1) & 4. rapidly inactivated \tn 
% Row Count 9 (+ 3)
% Row 18
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{a. Increase endothelial cell adhesion molecule expression} \tn 
% Row Count 11 (+ 2)
% Row 19
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{b. Activation and aggregation of PMN} \tn 
% Row Count 12 (+ 1)
% Row 20
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\mymulticolumn{2}{x{8.4cm}}{c. Systemic acute-phase response:Fever} \tn 
% Row Count 13 (+ 1)
% Row 21
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\mymulticolumn{2}{x{8.4cm}}{{\bf{Chemokines}}} \tn 
% Row Count 14 (+ 1)
% Row 22
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\mymulticolumn{2}{x{8.4cm}}{- Attract WBC} \tn 
% Row Count 15 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
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\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Chronic inflammation}}  \tn
% Row 0
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\mymulticolumn{1}{x{8.4cm}}{{\bf{Causes}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. Prolonged inflammation} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{2. Prolonged toxic substance exposure} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{3. Autoimmune disease} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Morphological change}}  \tn
% Row 0
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\mymulticolumn{1}{x{8.4cm}}{1. Mononuclear cell infiltration (e.g. macrophage, lymphocyte, plasma cell)} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{2. Cell destruction by inflammatory cells} \tn 
% Row Count 3 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{3. Repair attempts by fibrosis \& angiogenesis} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Types of inflammation}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Granulomatus inflammation}} & {\bf{Defective inflammation}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
- Produce granuloma containing an difficult offending agent & -delayed wound healing \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
- squamous\textgreater{}epitheloid & {\bf{Excessive inflammation}} \tn 
% Row Count 7 (+ 2)
% Row 3
\SetRowColor{white}
- fuse\textgreater{} multinuclear giant cell & - Abnormal reaction of body e.g. allergy \tn 
% Row Count 9 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & - Fibrosis \& tissue injuries \tn 
% Row Count 11 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Scar formation steps(Connective tissue deposition)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{1. Angiogenesis} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{2. Granulation tissue formation} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{3. Connective tissue remodelling'} \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Cutaneous wound healing(1)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Clean wound, only epithelial layer} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Inflammatory phase}}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{1. Formation of blood clot} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Neutrophil appears after 24hrs} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Proteolytic enzyme to clean out debris and invading bacteria} \tn 
% Row Count 6 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Proliferative phase}}} \tn 
% Row Count 7 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{1. Formation of granulation tissue}}} \tn 
% Row Count 8 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Induction of fibroblast and endothelial cell proliferation} \tn 
% Row Count 10 (+ 2)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Composed of newly formed thin capillaries \& loose ECM also} \tn 
% Row Count 12 (+ 2)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Peak at day5} \tn 
% Row Count 13 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- To cover the wound} \tn 
% Row Count 14 (+ 1)
% Row 11
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{2. Angiogenesis}}} \tn 
% Row Count 15 (+ 1)
% Row 12
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{i. {\bf{VEGF}} \textgreater{}Vasodilation\& I+permeability} \tn 
% Row Count 16 (+ 1)
% Row 13
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{ii. Proteolytic degradation of parent vessel BM\textgreater{}\textgreater{} capillary sprout} \tn 
% Row Count 18 (+ 2)
% Row 14
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{iii. Migration of endothelial cells toward angiogenetic stimulus} \tn 
% Row Count 20 (+ 2)
% Row 15
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{iv. Proliferation of endothelial cell behind leading edge of migrating cells} \tn 
% Row Count 22 (+ 2)
% Row 16
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{v.Maturation of end. cells into capillary tubes} \tn 
% Row Count 23 (+ 1)
% Row 17
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{vi. Recruitment of periendothelial cells for mature vessel} \tn 
% Row Count 25 (+ 2)
% Row 18
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{3.Cell proliferation and collagen deposition}}} \tn 
% Row Count 26 (+ 1)
% Row 19
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Macrophage replace neutrophils after 48hrs (key cellular constituents\textgreater{} main resource for chemokines \& GF)} \tn 
% Row Count 29 (+ 3)
% Row 20
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Migration and proliferation of fibroblast at injury site \textgreater{} secrete and deposit collagen} \tn 
% Row Count 31 (+ 2)
\end{tabularx}
\par\addvspace{1.3em}

\vfill
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\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Cutaneous wound healing(1) (cont)}}  \tn
% Row 21
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\mymulticolumn{1}{x{8.4cm}}{- Epithelial cells proliferate to centre of wound} \tn 
% Row Count 1 (+ 1)
% Row 22
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Remodeling phase}}} \tn 
% Row Count 2 (+ 1)
% Row 23
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{4. Scar formation}}} \tn 
% Row Count 3 (+ 1)
% Row 24
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Granulation tissue\textgreater{}Scar} \tn 
% Row Count 4 (+ 1)
% Row 25
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Composed of inactive spindle-shaped fibroblasts, dense collagen, fragments of elastic tissue, ECM} \tn 
% Row Count 6 (+ 2)
% Row 26
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Pale, avascular} \tn 
% Row Count 7 (+ 1)
% Row 27
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{5. Connective tissue remodeling}}} \tn 
% Row Count 8 (+ 1)
% Row 28
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{-Balance between ECM synthesis \& degradation} \tn 
% Row Count 9 (+ 1)
% Row 29
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Degradation of collagen \& MMPs \textgreater{} smaller \& softer scar} \tn 
% Row Count 11 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Defective}}  \tn
% Row 0
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\mymulticolumn{1}{x{8.4cm}}{{\bf{1.Defective scar formation}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Ulceration} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{2.Excessive sf}} (keloid)} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{3.Contracture}}} \tn 
% Row Count 4 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Cellular response}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{important leukocyte; neutrophil and macrophages} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{1. Adhesion to endothelium}}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{a. Margination}}} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- stasis of blood \textgreater{}settle out the central flow and marginate along endothelium surface} \tn 
% Row Count 5 (+ 2)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{b. Rolling}}} \tn 
% Row Count 6 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- complementary surface adhesion molecules sticks and release \textgreater{} rolling along} \tn 
% Row Count 8 (+ 2)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- mediated by selectins, regulated by cytokines} \tn 
% Row Count 9 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{c. Adhesion}}} \tn 
% Row Count 10 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- mediated by intergrins} \tn 
% Row Count 11 (+ 1)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{\seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_}} \tn 
% Row Count 12 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{2.Migration thru endo}}} \tn 
% Row Count 13 (+ 1)
% Row 11
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{-secrete collagenase thru basement membrane} \tn 
% Row Count 14 (+ 1)
% Row 12
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- migrate toward chemotactic gradient} \tn 
% Row Count 15 (+ 1)
% Row 13
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{\seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_}} \tn 
% Row Count 16 (+ 1)
% Row 14
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{3.Chemotaxi}}} \tn 
% Row Count 17 (+ 1)
% Row 15
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{-neutrophil\textgreater{}monocyte\textgreater{}macrophage} \tn 
% Row Count 18 (+ 1)
% Row 16
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{\seqsplit{\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_}} \tn 
% Row Count 19 (+ 1)
% Row 17
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{4.Phagocytosis}}} \tn 
% Row Count 20 (+ 1)
% Row 18
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{a. Recognition by receptors to sd signals} \tn 
% Row Count 21 (+ 1)
% Row 19
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{b. Activation by cytosolic Ca2+ and enzymes} \tn 
% Row Count 22 (+ 1)
% Row 20
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{c. Engulf \& Degradation} \tn 
% Row Count 23 (+ 1)
% Row 21
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{d. anti-inflammatory effects and wound repair} \tn 
% Row Count 24 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.04 cm} x{4.96 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Morphologic patterns and systemic effects}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Morphologic patterns}} & {\bf{Cytokine-induced systemic reaction aka Acute-phase responses}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{1.Serous}} & 1.Fever by pyrogens \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
{\bf{2. Fibrinous }} & 2. Leukocytosis \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
- Increase cell fibrin & 3.Phase proteins \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
- risk of scar formation & - CRP, Fibrinogen,SAA \tn 
% Row Count 10 (+ 2)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{{\bf{3.Purulent}}} \tn 
% Row Count 11 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{-Pus, leukocyte and debris} \tn 
% Row Count 12 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{{\bf{4. Ulcer}}} \tn 
% Row Count 13 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{- Open lesion} \tn 
% Row Count 14 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Possible outcomes}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{1.Complete resolution}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{2. Fibrosis/scarring}}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{3.Chronic inflammation}}} \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Cells and mediators}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Macrophage}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- dominant, from monocyte} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Activated by: }}} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. Classical pathway (microbicidal action)} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{2. Alternative pathway} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Functions}}} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{1. Phagocytosis and destruction} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{2. Initiate tissue repair \& scar formation and fibrosis involvement} \tn 
% Row Count 9 (+ 2)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{3. Secrete inflammation mediators (e.g. cytokines, clotting factors)} \tn 
% Row Count 11 (+ 2)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{4. Processing and presentation of Ag to immune system} \tn 
% Row Count 13 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Tissue repair -{}- Regeneration (Cell proliferation)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Depend on:}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. Cell types (Ability to repair)} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{2. Degree of injury} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Proliferative potential}}} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{1. Labile (continuo)} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- e.g. epithelial cell, xxx tract} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{2. Stable} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- e.g. salivary gland} \tn 
% Row Count 8 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{3. Permanent} \tn 
% Row Count 9 (+ 1)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- e.g. neuron, myocardium} \tn 
% Row Count 10 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{} \tn 
% Row Count 10 (+ 0)
% Row 11
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Regulation mechanism}}} \tn 
% Row Count 11 (+ 1)
% Row 12
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{1. Growth factors }} (+population,size,mitosis,survival)} \tn 
% Row Count 13 (+ 2)
% Row 13
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{-VEGF} \tn 
% Row Count 14 (+ 1)
% Row 14
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{2. ECM}}} \tn 
% Row Count 15 (+ 1)
% Row 15
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Cell-matrix interactions}}} \tn 
% Row Count 16 (+ 1)
% Row 16
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{總之講緊growth同 differentiation要用at least 2 types of signal \seqsplit{一個就用soluble(growth} factor) \seqsplit{另一個就用insoluble(ECM)}} \tn 
% Row Count 19 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Secondary intention}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Cell loss more extensive} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Features}}} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{1. More intense inflammatory tissue} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{2. Abundant granulation tissue} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{3. ECM accumulation} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{4. Formation of large scar} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Destroyed appendage are permanently lost} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{5. Wound contraction}}} \tn 
% Row Count 8 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Reduce gap between dermal edge and wound area to close wound} \tn 
% Row Count 10 (+ 2)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Myofibroblast for mediator} \tn 
% Row Count 11 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{6. Fibrosis}}} \tn 
% Row Count 12 (+ 1)
% Row 11
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Excessive collagen deposit} \tn 
% Row Count 13 (+ 1)
% Row 12
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Pathologic process by persistent stimuli} \tn 
% Row Count 14 (+ 1)
% Row 13
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{- Associated with loss of tissue} \tn 
% Row Count 15 (+ 1)
% Row 14
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{- Long-lasting} \tn 
% Row Count 16 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Healing Factors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Systemic}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. Overall nutrition e.g. VitC} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{2. Metabolic status \textgreater{} Vascular supply} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{3. Circulatory status} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{4. Hormones \textgreater{} Cortico :(} \tn 
% Row Count 5 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{5. Age} \tn 
% Row Count 6 (+ 1)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Local}}} \tn 
% Row Count 7 (+ 1)
% Row 7
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{1. Infection} \tn 
% Row Count 8 (+ 1)
% Row 8
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{2. Movement} \tn 
% Row Count 9 (+ 1)
% Row 9
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{3. Type, size, location} \tn 
% Row Count 10 (+ 1)
% Row 10
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{4. Foreign bodies} \tn 
% Row Count 11 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}