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% Document Info
\author{Thomas Von Chao (chautommy93)}
\pdfinfo{
  /Title (parasymphathetic-agents-agonist-and-antagonist.pdf)
  /Creator (Cheatography)
  /Author (Thomas Von Chao (chautommy93))
  /Subject (Parasymphathetic Agents (Agonist \& Antagonist) Cheat Sheet)
}

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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Parasymphathetic Agents (Agonist \& Antagonist) Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Thomas Von Chao (chautommy93)} via \textcolor{DarkBackground}{\uline{cheatography.com/178810/cs/37276/}}}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Thomas Von Chao (chautommy93) \\
  \uline{cheatography.com/chautommy93} \\
  \end{tabulary}
\vfill
\columnbreak
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 22nd February, 2023.\\
   Updated 22nd February, 2023.\\
   Page {\thepage} of \pageref{LastPage}.
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
\raggedright
\raggedcolumns

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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{x{4.4 cm} x{3.6 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Muscarinic ACh receptors (mAChRs) Location}}  \tn
% Row 0
\SetRowColor{LightBackground}
Muscarinic 1 (M1) & Ganglia cells \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Muscarinic 2 (M2) & Cardiac muscle \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
Muscarinic 3 (M3) & Sweat glands \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Muscarinic 4 \& 5 (M4 \& M5) are NOT very important in this module.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.876 cm} x{2.508 cm} x{1.216 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Muscarinic Effects on Organ}}  \tn
% Row 0
\SetRowColor{LightBackground}
Heart & ↓HR & M2 \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Eye (circular musc.) & Pinpoint pupil & M2 \& M3 \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Eye (cilliary musc.) & Contract & M3 \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
Vascular musc. & Relax & M3 (NO) \tn 
% Row Count 6 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Lungs (Broncho mus.) & Contract & M3 \tn 
% Row Count 7 (+ 1)
% Row 5
\SetRowColor{white}
GI-tract & ↑ motiility & M3 \tn 
% Row Count 8 (+ 1)
% Row 6
\SetRowColor{LightBackground}
Genito-urinary musc. & Contract & M3 \tn 
% Row Count 9 (+ 1)
% Row 7
\SetRowColor{white}
Sweat \& Salivary Gland & ↑ excretion & M3 \tn 
% Row Count 11 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.08 cm} x{5.92 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Parasympathetic Agonist Effects}}  \tn
% Row 0
\SetRowColor{LightBackground}
Heart & ↓ CO = ↓ contraction \& ↓ AV conduction speed = BRADYcardia \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
Vascular musc. & Vasodilation via (NO) production \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Smooth musc. & ↑ intestine \& bladder tone (motility) \& ↓ sphincter tone \tn 
% Row Count 8 (+ 3)
% Row 3
\SetRowColor{white}
Eye & ↑ contraction of sphincter (miosis) \& ciliary muscle (NEAR vision) \tn 
% Row Count 11 (+ 3)
% Row 4
\SetRowColor{LightBackground}
Glands & ↑ sweating, saliva, gastric acid secretion \tn 
% Row Count 13 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Parasympathetic Agonist = Activation = INactivate sympathetic actions \newline (Think OPPOSITE of ALL sympathetic activation)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.32 cm} x{5.68 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Parasympathetic Antagonist Effects}}  \tn
% Row 0
\SetRowColor{LightBackground}
Heart & ↑CO = ↑AV node firing = ↑ HR = TACHYcardia \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Vascular musc. & NO EFFECT b/c NO innervation \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Smooth musc. & Relaxation =  ↓GI \& Urinary tract contraction \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
Eye & Pupil dilation \& Loss of NEAR focus (FAR vision) \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
Glands & ↓ sweat, saliva, gastric acid secretion \tn 
% Row Count 10 (+ 2)
% Row 5
\SetRowColor{white}
Central NS (CNS) & Belladonna Symptoms \tn 
% Row Count 12 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{Belladonna Symptoms: "mad as a hatter, red as a beet, blind as a bat, hot as hell, dry as a bone"}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.76 cm} x{6.24 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Eye Terminology}}  \tn
% Row 0
\SetRowColor{LightBackground}
Miosis & Paralysis of ciliary muscle (loss of accommodation, ability to focus) \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\seqsplit{Mydriatic} & Contraction of pupil (leads to pinpoint pupil, ie. Ach) \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Cycloplegia} & Relaxation of pupil (dilation); Atropine: belladonna compound) \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.08 cm} x{5.92 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Antagonist: Parasympatholytic Agents}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Antimuscarinic} & Block ACh in Parasymp. Effector Junctions \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{Antinicotinic} & Block ACh in Ganglia (Para- \& Sympathic; NN/N1) \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\seqsplit{Antinicotinic} & Block ACh in NMJ (skeletal muscle relaxant, NM/N2) \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{} \tn 
% Row Count 6 (+ 0)
% Row 4
\SetRowColor{LightBackground}
\seqsplit{Antinicotinic} & Block ACh in Ganglia (both Para- \& Sympathetic, NN/N1) \tn 
% Row Count 8 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Agonist: Parasympathomimetic Agents}}  \tn
\SetRowColor{LightBackground}
\mymulticolumn{1}{p{8.4cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/chautommy93_1677098532_Screenshot 2023-02-22 at 3.40.14 PM.png}}} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Directly-Acting: Combine with mACh and/or \newline nAChs cholinoceptors receptor directly → Direct activation.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.72 cm} x{5.28 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Parasympathetic Agents}}  \tn
% Row 0
\SetRowColor{LightBackground}
Agonist & (1) Acetylcholine, ACh  (2) Bethanecol  (3) Pilocarpine          (4) Methacholine \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
Antagonist (-tropine) & (1) Atropine  (2) Scopolamine  (3) Homatropine  (4) Benzotropine  (5) pirenzepine \tn 
% Row Count 8 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{p{0.76 cm} x{3.04 cm} x{3.8 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Directly-Acting PNS Agonist}}  \tn
% Row 0
\SetRowColor{LightBackground}
mAChs & Choline Ester & Acetylcholine; Methacholine \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 &  & Carbachol; Bethanechol \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
 & Alkaloids & Muscarine; Pilocarpine \tn 
% Row Count 6 (+ 2)
% Row 3
\SetRowColor{white}
nAChs & Ganglionic Stimulants & Acetylcholine; Nicotine \tn 
% Row Count 8 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 &  & Vareniclinie (partial) \tn 
% Row Count 10 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{Choline Ester: Short-acting; stay in blood stream; NO (X) BBB \newline Alkaloids: (X) BBB}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.88 cm} x{5.12 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{mAChs Agonists Uses}}  \tn
% Row 0
\SetRowColor{LightBackground}
Acetylcholine & Ophthalmic (brief miosis) \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
Methacholine & Belladonna poisoning; Urinary retention \tn 
% Row Count 3 (+ 2)
% Row 2
\SetRowColor{LightBackground}
Bethanechol & Reverse post-op GI depression \tn 
% Row Count 5 (+ 2)
% Row 3
\SetRowColor{white}
Pilocarpine (alkaloid) & DOC for Glaucoma \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.9 cm} x{2.888 cm} x{2.812 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Acetylcholinesterase Inhibitors (AChEIs)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\seqsplit{Reversible} & Edrophonium (Tensilon) & For myasthenia gravis (extreme muscle weakness) \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
\seqsplit{Irreversible} (comp. Inhibs) & Neostigmine & NO (X) BBB; For myasthenia gravis \& ileus \tn 
% Row Count 7 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & Physostigmine & (X) BBB; For glaucoma and for treatment of belladonna poisoning \tn 
% Row Count 12 (+ 5)
% Row 3
\SetRowColor{white}
 & Pyridostigmine & Myasthenia gravis \tn 
% Row Count 14 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & Ambenonium & Myasthenia gravis \tn 
% Row Count 16 (+ 2)
% Row 5
\SetRowColor{white}
Slow \seqsplit{Reversible} & Echothiophate & Glaucoma \tn 
% Row Count 18 (+ 2)
% Row 6
\SetRowColor{LightBackground}
 & \seqsplit{Organophosphate} insecticides, nerve gases DFP & N/A \tn 
% Row Count 21 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{Inhibits AChE at both mAChs \& nACh via ↑ synaptic concentration \& half-life of Ach.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.64 cm} x{5.36 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Symptoms from Excess Cholinergic activity}}  \tn
% Row 0
\SetRowColor{LightBackground}
General (SLUDE) & Salivation, Lacrimation, Urination, Diarrhea, Emesis \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
Muscarinic (SLUGBAM) & Salivation/Sz, Lacrimation, Urination, GI distress (D/V), Bronchoconstriction, Abd. cramps, Miosis \tn 
% Row Count 6 (+ 4)
% Row 2
\SetRowColor{LightBackground}
Nicotinic (MTWThF) & Mydriasis, Tachycardia, Weakness (musc. paralysis), hyperTHermia, Fasciculation \tn 
% Row Count 10 (+ 4)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{} \tn 
% Row Count 10 (+ 0)
% Row 4
\SetRowColor{LightBackground}
Muscarinic (SLUGBAM) & Salivation/Sz, Lacrimation, Urination, GI distress (D/V), Bronchoconstriction, Abd. cramps, Miosis \tn 
% Row Count 14 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}