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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
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% Document Info
\author{Thomas Von Chao (chautommy93)}
\pdfinfo{
  /Title (bugs-to-drugs.pdf)
  /Creator (Cheatography)
  /Author (Thomas Von Chao (chautommy93))
  /Subject (Bugs-to-Drugs Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Bugs-to-Drugs Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Thomas Von Chao (chautommy93)} via \textcolor{DarkBackground}{\uline{cheatography.com/178810/cs/42638/}}}
\end{tabulary}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Thomas Von Chao (chautommy93) \\
  \uline{cheatography.com/chautommy93} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 7th March, 2024.\\
   Updated 7th March, 2024.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
  \SetRowColor{white}
  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
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\begin{document}
\raggedright
\raggedcolumns

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% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactams: Penicillin Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Notes}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Natural Penicillin}}  \{\{nl\}\} (PCN G / PCN V) & ↦  Strep  \{\{nl\}\} ↦  Staph \seqsplit{(non-β-lactamase)}  \{\{nl\}\} ↦  Treponema pallidum (syphilis) & DOC for Syphilis \tn 
% Row Count 9 (+ 7)
% Row 2
\SetRowColor{LightBackground}
{\bf{Anti-Staph. Penicillin}}  \{\{nl\}\} (Nafcillin / \seqsplit{Dicloxacillin)} & ↦  Staph. aureus \seqsplit{(penicillinase-producing)} \{\{nl\}\} ↦  Some Strep & DOC for MSSA infections \tn 
% Row Count 15 (+ 6)
% Row 3
\SetRowColor{white}
{\bf{Aminopenicillins}}  \{\{nl\}\} (Ampicillin / Amoxicillin) & ↦  \seqsplit{Streptococcus} spp.  \{\{nl\}\} ↦  Enterococcus faecalis  \{\{nl\}\} ↦  \seqsplit{Enterobacteriaceae} (some) \{\{nl\}\} ↦  Listeria \seqsplit{monocytogenes} & DOC for susceptible Enterococcus and Listeria infections \tn 
% Row Count 26 (+ 11)
% Row 4
\SetRowColor{LightBackground}
{\bf{Amoxicillin/clavulanate}} \seqsplit{(Augmentin®)} & ↦  Strep + Staph. aureus  \{\{nl\}\} ↦  E. coli + Klebsiella  \{\{nl\}\} ↦  H. flu + Moraxella catarrhalis  \{\{nl\}\} ↦  Anaerobes & Mixed infections:  \{\{nl\}\}  \seqsplit{(GP+GN+anaerobes)} such as Diabetic Foot Ulcers \tn 
% Row Count 36 (+ 10)
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactams: Penicillin Family (cont)}}  \tn
% Row 5
\SetRowColor{LightBackground}
{\bf{Ampicillin/sulbactam}} (Unasyn®) & Similar to \seqsplit{Amoxicillin/clavulanate} + broader activity against anaerobes \{\{nl\}\} (sulbactam = \seqsplit{acinetobacter)} & Mixed infections:  \{\{nl\}\} \seqsplit{(GP+GN+anaerobes)} such as Diabetic Foot Ulcers \tn 
% Row Count 9 (+ 9)
% Row 6
\SetRowColor{white}
{\bf{Piperacillin/tazobactam}} (Zosyn®) & Similar to \seqsplit{Amoxicillin/clavulanate} + Pseudomonas aeruginosa & Same as above PLUS Pseudomonas \tn 
% Row Count 14 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Mechanism of Action: \newline 1. Binds to Penicillin Binding Proteins (PBPs) located on the bacterial cell wall \newline 2. PBPs catalyze peptidoglycan synthesize which interferes with bacterial cell wall \newline construction → Bacteria lysis and death \newline 3. Number and type of PBPs vary between different bacteria \newline 4. Time Dependent killing}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactam: Cephalosporin}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{1st Generation}}   \{\{nl\}\} (Cefazolin / Cephalexin) & ↦  \seqsplit{Streptococcus} + Staph (including some MSSA)  \{\{nl\}\} ↦  PEK: Proteus, E. coli, Klebsiella pneumoniae & SSTI  \{\{nl\}\} Surgical prophylaxis \tn 
% Row Count 11 (+ 9)
% Row 2
\SetRowColor{LightBackground}
{\bf{2nd Generation}}   \{\{nl\}\} (Cefoxitin / Cefotetan) & Enhanced activity against gram (–) bacteria including  \{\{nl\}\}  ↦  Some anaerobes (B. fragilis)  \{\{nl\}\} ↦  \seqsplit{Streptococcus} + Staph (including some MSSA)  \{\{nl\}\} ↦  H. flu + Enterobacter aerogenes & \seqsplit{Intra-abdominal} infections  \{\{nl\}\} Prophylaxis pre-surgery \tn 
% Row Count 27 (+ 16)
% Row 3
\SetRowColor{white}
{\bf{2nd Generation}}  \{\{nl\}\}  (Cefuroxime / Cefaclor) & ↦  \seqsplit{Streptococcus} + Staph (including some MSSA)  \{\{nl\}\} ↦  H. influenzae + M. catarrhalis + Neisseria (some)  \{\{nl\}\} ↦  E. coli + K. pneumoniae & URT infections \tn 
% Row Count 39 (+ 12)
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactam: Cephalosporin (cont)}}  \tn
% Row 4
\SetRowColor{LightBackground}
{\bf{3rd Generation}}  \{\{nl\}\}  (Ceftriaxone / Ceftazidime) & Broad spectrum including   \{\{nl\}\} ↦  Many gram (–) bacteria  \{\{nl\}\} ↦  \seqsplit{Streptococcus} + Staph (including some MSSA)  \{\{nl\}\} ↦  H. influenzae + M. catarrhalis + Neisseria  \{\{nl\}\} ↦  (Ceftazidime = Pseudomonas) & Meningitis  \{\{nl\}\} Gonorrhea \seqsplit{(Ceftriaxone)} \tn 
% Row Count 17 (+ 17)
% Row 5
\SetRowColor{white}
{\bf{3rd Generation}}  \{\{nl\}\}  (Cefixime / Cefpodoxime / Cefdinir) & ↦  \seqsplit{Streptococcus} + Staph (including some MSSA)  \{\{nl\}\} ↦  H. influenzae + M. catarrhalis  \{\{nl\}\} ↦  \seqsplit{Enterobacteriaceae:} E. coli + K. pneumoniae & \seqsplit{Community-acquired} infections \tn 
% Row Count 29 (+ 12)
% Row 6
\SetRowColor{LightBackground}
{\bf{4th Generation}}  \{\{nl\}\}  (Cefepime) & \seqsplit{Broad-spectrum} activity including   \{\{nl\}\} ↦  Pseudomonas aeruginosa  \{\{nl\}\} ↦  Many gram (–) bacteria  \{\{nl\}\} ↦  \seqsplit{Streptococcus} + Staph (including some MSSA) & HAP  \{\{nl\}\} Febrile neutropenia \tn 
% Row Count 42 (+ 13)
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactam: Cephalosporin (cont)}}  \tn
% Row 7
\SetRowColor{LightBackground}
{\bf{5th Generation/Anti-MRSA}}   \{\{nl\}\} \seqsplit{(Ceftaroline)} & Broad spectrum including   \{\{nl\}\} ↦  MRSA + \seqsplit{Streptococcus} spp  \{\{nl\}\} ↦  Some gram (–) bacteria  \{\{nl\}\} & SSTI  \{\{nl\}\} CAP \tn 
% Row Count 9 (+ 9)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Very safe antibiotics \newline Less frequent dosing compared to PCNs \newline Cephalosporins are intrinsically resistant to ALL Enterococci and Listeria species \newline All agents are metabolized by the kidneys EXCEPT Ceftriaxone (hepatic metabolism; hepatic/renal excretion)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactam: Carbapenems Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Imipenem/Cilastatin}}  \{\{nl\}\} {\bf{Meropenem}} & ↦  Gram (+) – Not Enterococcus faecium  \{\{nl\}\} ↦  Gram (–) \& Pseudomonas  \{\{nl\}\} ↦  Anaerobes & ↦  DOC for Enterobacter, Serratia and ESBL  \{\{nl\}\} ↦  Severe \seqsplit{hospital-acquired} infections  \{\{nl\}\} ↦  Complicated infections \tn 
% Row Count 12 (+ 10)
% Row 2
\SetRowColor{LightBackground}
{\bf{Ertapenem}} & ↦  Gram (+) cocci  \{\{nl\}\} ↦  Many Gram (–) rods  \{\{nl\}\} ↦  Anaerobes  \{\{nl\}\} ↦  Less active against Pseudomonas and \seqsplit{Acinetobacter} & ↦  CAP  \{\{nl\}\} ↦  Complicated \seqsplit{intra-abdominal} infections \tn 
% Row Count 23 (+ 11)
% Row 3
\SetRowColor{white}
{\bf{Meropenem/Vaborbactam}}  \{\{nl\}\} {\bf{Imipenem/Cilastatin/Relebactam}} & Same as ABOVE PLUS  \{\{nl\}\} ↦  Resistant gram (–) such as CRE & ↦  Complicated UTIs  \{\{nl\}\} ↦  HAP/VAP \tn 
% Row Count 29 (+ 6)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Carbapenems are very broad spectrum (similar in activity to Piperacillin/Tazobactam) and usually used for hospital \seqsplit{acquired/serious/resistant} infections \newline 1) Usually used for hospital acquired organisms that have developed resistance to other cell wall inhibitors (aka, Extended Spectrum Beta Lactamase Producers) \newline 2) Reserve to use for resistant infections}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Beta-Lactam: Monobactam Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Aztreonam}} & ↦  ONLY Gram (–) including Neisseria, H. flu, \seqsplit{Enterobacteriaceae}, and Pseudomonas  \{\{nl\}\} ↦  No anaerobes & ↦  Alternative agent for GRAM (-) infections in those with PCN allergies  \{\{nl\}\} ↦  Mainly for hospital related infections, critically ill, or sepsis. \tn 
% Row Count 14 (+ 11)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Narrower spectrum of activity compared to other beta-lactams \newline 1) ONLY Gram (-) activity, no anaerobes \newline 2) No cross reactivity with other beta-lactams \newline 3) Can be used safely in those with PCN allergies}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Vancomycin and Glycopeptides}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Vancomycin}} & ↦  ONLY gram (+) including MRSA and sensitive Enterococci  \{\{nl\}\} ↦  PO for C. diff & ↦  For either resistant infections or beta-Lactam allergies \{\{nl\}\} ↦  Must monitor levels: AUC/MIC ratio  \{\{nl\}\} ↦  PO can be used for C. diff infections \tn 
% Row Count 14 (+ 11)
% Row 2
\SetRowColor{LightBackground}
{\bf{Televancin}} & ↦  Only Gram (+) including MRSA and sensitive Enterococci  \{\{nl\}\} ↦  DOES NOT cover VRE & ↦  Potentially can be used for \seqsplit{Vancomycin-resistant} S. aureus (VRSA) \{\{nl\}\} ↦  Increase mortality when used for HAP with renal impairment  \{\{nl\}\} ↦  \seqsplit{Contraindicated} in pregnancy \tn 
% Row Count 27 (+ 13)
% Row 3
\SetRowColor{white}
{\bf{Dalbavancin}} & ↦  Only Gram (+) including MRSA and sensitive Enterococci & ↦  Skin/Soft Tissue Infections (SSTIs) \tn 
% Row Count 31 (+ 4)
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Vancomycin and Glycopeptides (cont)}}  \tn
% Row 4
\SetRowColor{LightBackground}
{\bf{Oritavancin}} & ↦  Only Gram (+) including MRSA and sensitive Enterococci  \{\{nl\}\} ↦  COVERS VRE & ↦  Skin/Soft Tissue Infections (SSTIs) \tn 
% Row Count 6 (+ 6)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{1) Only has Gram (+) Activity \newline 2) Mainly used to cover either Beta-Lactam Resistant Infections (MRSA, PCN resistant Strep pneumo, Amp resistant Enterococcus) OR \newline 3) Alternative for Gram (+) infections in those with Beta-Lactam allergies}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{2.5305 cm} x{7.0854 cm} x{7.2541 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Daptomycin vs. Polymyxin (Colistin)}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Daptomycin}} & ONLY Gram (+) and for  resistance infection including  \{\{nl\}\} ↦  \seqsplit{MRSA/MSSA/VISA/VRSA}  \{\{nl\}\} ↦  Enterococci (include VRE)  \{\{nl\}\} ↦  Streptococcus & ↦  Alternative agent for GRAM (-) infections in those with PCN allergies  \{\{nl\}\} ↦  Mainly for hospital related infections, critically ill, or sepsis. \tn 
% Row Count 10 (+ 10)
% Row 1
\SetRowColor{white}
{\bf{Colistin}} & Resistant Gram (–) infections including Pseudomonas & For resistant Gram (-) infections \tn 
% Row Count 14 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Daptomycin: Cannot use for pneumonia due to inactivation by lung surfactant \newline Polymyxin: Old class of drugs that have gained new popularity for resistant Gram (-) infections}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Macrolide Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Erythromycin}} & ↦  Gram (+)  \{\{nl\}\} ↦  Gram (–)  \{\{nl\}\} ↦  Atypical organisms  \{\{nl\}\} ↦  Mycobacterium sp. & ↦  CAP / Sinusitis / Otitis Media  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  Lyme's disease \tn 
% Row Count 10 (+ 7)
% Row 2
\SetRowColor{LightBackground}
{\bf{Clarithromycin}} & ↦  Gram (+)  \{\{nl\}\} ↦  Gram (–)  \{\{nl\}\} ↦  Atypical organisms  \{\{nl\}\} ↦  Mycobacterium sp.  \{\{nl\}\} ↦  BETTER H.flu coverage & ↦  CAP / Sinusitis / Otitis Media  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  Lyme's disease ↦  Mycobacterial infections \tn 
% Row Count 19 (+ 9)
% Row 3
\SetRowColor{white}
{\bf{Azithromycin}} & ↦  Gram (+), but less activity \{\{nl\}\} ↦  Gram (–)  \{\{nl\}\} ↦  Atypical organisms  \{\{nl\}\} ↦  Mycobacterium sp.  \{\{nl\}\} ↦  BETTER H.flu coverage & ↦  CAP / Sinusitis / Otitis Media  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  Lyme's disease  \{\{nl\}\} ↦  Mycobacterial infections  \{\{nl\}\} ↦  Frequently used as one time dose (1 g) for Chlamydia treatment. \tn 
% Row Count 34 (+ 15)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Can be used safely with PCN allergies}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Macrolide Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Erythromycin}} & ↦  Gram (+)  \{\{nl\}\} ↦  Gram (–)  \{\{nl\}\} ↦  Atypical organisms  \{\{nl\}\} ↦  Mycobacterium sp. & ↦  CAP / Sinusitis / Otitis Media  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  Lyme's disease \tn 
% Row Count 10 (+ 7)
% Row 2
\SetRowColor{LightBackground}
{\bf{Clarithromycin}} & ↦  Gram (+)  \{\{nl\}\} ↦  Gram (–)  \{\{nl\}\} ↦  Atypical organisms  \{\{nl\}\} ↦  Mycobacterium sp.  \{\{nl\}\} ↦  BETTER H.flu coverage & ↦  CAP / Sinusitis / Otitis Media  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  Lyme's disease ↦  Mycobacterial infections \tn 
% Row Count 19 (+ 9)
% Row 3
\SetRowColor{white}
{\bf{Azithromycin}} & ↦  Gram (+), but less activity \{\{nl\}\} ↦  Gram (–)  \{\{nl\}\} ↦  Atypical organisms  \{\{nl\}\} ↦  Mycobacterium sp.  \{\{nl\}\} ↦  BETTER H.flu coverage & ↦  CAP / Sinusitis / Otitis Media  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  Lyme's disease  \{\{nl\}\} ↦  Mycobacterial infections  \{\{nl\}\} ↦  Frequently used as one time dose (1 g) for Chlamydia treatment. \tn 
% Row Count 34 (+ 15)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Can be used safely with PCN allergies}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Tetracyclines Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Tetracycline}}\{\{nl\}\} {\bf{Doxycycline}}\{\{nl\}\} {\bf{Minocycline}} & Gram (+)  \{\{nl\}\} ↦  MRSA \& \seqsplit{Streptococcus}  \{\{nl\}\} Some Gram (-)  \{\{nl\}\} ↦  Atypical infections  \{\{nl\}\} ↦  \seqsplit{Chlamydia/gonorrhea}  \{\{nl\}\} ↦  Tick borne disease & ↦  Tick or spider bites  \{\{nl\}\} ↦  Lyme's Disease  \{\{nl\}\} ↦  CAP  \{\{nl\}\} ↦  SSTI, esp. MRSA  \{\{nl\}\} ↦  Atypical respiratory infections \tn 
% Row Count 15 (+ 13)
% Row 2
\SetRowColor{LightBackground}
{\bf{Tigecycline}} & Gram (+)  \{\{nl\}\} ↦  MRSA \& \seqsplit{Streptococcus}  \{\{nl\}\} ↦  VRE  \{\{nl\}\} Some Gram (-)  \{\{nl\}\} Some Anaerobe  \{\{nl\}\} Atypical infections & ↦  \seqsplit{Chlamydia/gonorrhea}  \{\{nl\}\} ↦  Tick borne disease  \{\{nl\}\} ↦  Complicated IAI  \{\{nl\}\} ↦  Skin/soft tissue infections  \{\{nl\}\} ↦  MRSA/VRE infections \tn 
% Row Count 28 (+ 13)
% Row 3
\SetRowColor{white}
{\bf{Eravacycline}}\{\{nl\}\} {\bf{Omadacycline}} & Gram (+)  \{\{nl\}\} ↦  MRSA \& \seqsplit{Streptococcus}  \{\{nl\}\} ↦  VRE  \{\{nl\}\} Some Gram (-)  \{\{nl\}\} Some Anaerobe  \{\{nl\}\} Atypical infections & ↦  SSTI  \{\{nl\}\} ↦  CAP  \{\{nl\}\} ↦  Complicated \seqsplit{intra-abdominal} infection (IAI) \tn 
% Row Count 39 (+ 11)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Spectrum of Activity: Very Broad- Gram-positive (including MRSA), Gram-negative, Rickettsia and other Tick borne diseases, Chlamydia, some protozoa \newline Omadacycline, Eravacycline, and Tigecycline also cover enterococci (including VRE)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Aminoglycosides Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Tobramycin}} \{\{nl\}\} {\bf{Gentamicin}} \{\{nl\}\} {\bf{Amikacin}} \{\{nl\}\} & ↦  Gram (-) + Pseudomonas \{\{nl\}\} ↦  Gram (+)  → Synergy dosing for Enterococcal infective Endocarditis \{\{nl\}\} ↦  Amikacin only covers \seqsplit{mycobacterium} sp. & ↦  Resistant G- infections \{\{nl\}\} ↦  Synergy with \seqsplit{beta-lactam/glycopeptide} in enterococcal endocarditis \tn 
% Row Count 15 (+ 13)
% Row 2
\SetRowColor{LightBackground}
{\bf{Plazomicin}} & ↦  Gram (-) + Pseudomonas \{\{nl\}\} ↦  Gram (+) → Synergy w/ with a \seqsplit{beta-lactam/glycopeptide} for Enterococcal infective Endocarditis \{\{nl\}\} ↦  CRE & ↦  Resistant G- infections, including UTI \{\{nl\}\} ↦  Plague \tn 
% Row Count 27 (+ 12)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Spectrum of Activity \newline 1) Mostly Gram (-), mycobacterium, synergy for Gram + infections when used with a beta-lactam or glycopeptide \newline 2) Most frequently used now for resistant gram – infections or in combination with an extended spectrum beta-lactam (additional coverage for resistant Gram (-) infections) in serious infections such as neutropenic fever or sepsis}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Oxazolidinones Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Linezolid}} & ALL Gram (+) organisms  \{\{nl\}\} ↦  \seqsplit{MsSA/MRSA/VISA/VRSA}  \{\{nl\}\} ↦  Enterococci (VRE)  \{\{nl\}\} ↦  Streptococcus  \{\{nl\}\} Some Atypicals & ↦  SSTIs  \{\{nl\}\} ↦  Suspected MRSA / VRE infections \tn 
% Row Count 13 (+ 10)
% Row 2
\SetRowColor{LightBackground}
{\bf{Tedizolid}} & Same as ABOVE PLUS  \{\{nl\}\} ↦  Gram (-) anaerobes & ↦  SSTIs \tn 
% Row Count 17 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Spectrum of Activity: Gram + (MRSA + VRE) , some atypical organisms, Mycobacterium sp., and Nocardia}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Others Protein Synthesis Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Lincosamide}}\{\{nl\}\} \seqsplit{(Clindamycin)} & ↦  Gram (+) → MSSA + some MRSA  \{\{nl\}\} ↦  Anaerobes (esp. mouth) including \seqsplit{Peptostreptococcus}, Bacteroides, Prevotella, and \seqsplit{Fusobacterium} Strep + Staph infections & ↦  DOC for Pelvic Inflammatory Disease (PID)  \{\{nl\}\} ↦  Used in combo with PCN for toxin producing strains for Clostridium perfringens and S. pyogenes; commonly occurs with necrotizing fasciitis  \{\{nl\}\} ↦  Alternative for G+ infections with PCN allergy  \{\{nl\}\} ↦  Dental infections, IAI, and Pelvic infections  \{\{nl\}\} ↦  Can be used topically for acne \tn 
% Row Count 30 (+ 28)
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Others Protein Synthesis Inhibitors (cont)}}  \tn
% Row 2
\SetRowColor{LightBackground}
{\bf{Pleuromutilin}}\{\{nl\}\} (Lefamulin) & ↦  Gram (+) organisms  \{\{nl\}\} ↦  Gram (-) organisms (limited)  \{\{nl\}\} ↦  Atypicals & ↦  CAP \tn 
% Row Count 7 (+ 7)
% Row 3
\SetRowColor{white}
{\bf{Streptogramins}}\{\{nl\}\} \seqsplit{(Quinupristin/Dalfopristin)} & ↦  Gram (+) organisms  \{\{nl\}\} ↦  MSSA/MRSA  \{\{nl\}\} ↦  Strep  \{\{nl\}\} ↦  Enterococcus (VRE) &  \tn 
% Row Count 15 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Fluoroquinolones Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Ciprofloxacin}} & ↦  Mostly Gram (+) \{\{nl\}\} ↦  Some Gram (–) → Pseudomonas, but not as good as other agents \{\{nl\}\} ↦  Atypical organisms & ↦  UTIs  \{\{nl\}\} ↦  GNR bacteremia, bone/joint infections, hospital related infections  \{\{nl\}\} ↦  Alternative for GNR infections in those w/ beta-lactam allergies  \{\{nl\}\} ↦  DON'T use for respiratory infections \tn 
% Row Count 18 (+ 15)
% Row 2
\SetRowColor{LightBackground}
{\bf{Levofloxacin}} & ↦  Mostly Gram (+) \{\{nl\}\} ↦  Some Gram (–) → Pseudomonas, but not as good as other agents \{\{nl\}\} ↦  Atypical organisms & ↦  UTIs / CAP / SSTIs / Sinusitis  \{\{nl\}\} ↦  GNR bacteremia, bone/joint infections, and hospital related infections  \{\{nl\}\} ↦  Alternative for GNR infections in those w/ beta-lactam allergies  \{\{nl\}\} ↦  Alternative for mycobacterial infections \tn 
% Row Count 35 (+ 17)
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Fluoroquinolones Family (cont)}}  \tn
% Row 3
\SetRowColor{LightBackground}
{\bf{Delafloxacin}} & ↦  Gram (+): MRSA \{\{nl\}\} ↦  Some Gram (-) →Pseudomonas \{\{nl\}\} ↦  Atypical organisms & ↦  SSTIs \tn 
% Row Count 7 (+ 7)
% Row 4
\SetRowColor{white}
{\bf{Moxifloxacin}} & ↦  Mostly Gram (+)  \{\{nl\}\} ↦  Some Gram (-) → Not as good as other agents \{\{nl\}\} ↦  Atypical organisms \{\{nl\}\} ↦  Anaerobic coverage & ↦  CAP / SSTIs \tn 
% Row Count 17 (+ 10)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Spectrum of Activity: Varies by Agent, but broad spectrum (Gram +, Gram -, Atypical) \newline 1) Respiratory FQ: Levofloxacin, Delafloxacin, Moxifloxacin ("Let's Do Meditation") \newline 2) Pseudomonas: Levofloxacin, Ciprofloxacin, Delafloxacin ("Let's Cancer Die") \newline 3) Anaerobes: Moxifloxacin \newline 4) MRSA: Delafloxacin ("MR Del is like Modella beer")}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{3.7114 cm} x{6.5793 cm} x{6.5793 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Rifamycins Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{Rifampin}} & ↦  Mycobacterium species  \{\{nl\}\} ↦  Gram (+) → MRSA & ↦  Never use as solo agent \tn 
% Row Count 7 (+ 4)
% Row 2
\SetRowColor{LightBackground}
{\bf{Rifabutin}} & ↦  Mycobacterium species  \{\{nl\}\} & ↦  Less DDIs → Preferred drug for patients on \seqsplit{antiretrovirals} \tn 
% Row Count 12 (+ 5)
% Row 3
\SetRowColor{white}
{\bf{Rifapentine}} & ↦  Mycobacterium species &  \tn 
% Row Count 14 (+ 2)
% Row 4
\SetRowColor{LightBackground}
{\bf{Rifaximin}} & ↦  Gram (+)  \{\{nl\}\} ↦  Gram (-) → \seqsplit{Enterobacteriaceae} & ↦  Only active in GI tract  \{\{nl\}\} ↦  Can't use to treat systemic infections \tn 
% Row Count 20 (+ 6)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Spectrum of Activity \newline • Rifampin, Rifabutin, Rifapentine → Mycobacterium species \newline • Rifampin: Gram + (MRSA); never use ALONE \newline • Rifaximin: Gram +, Gram – such as Enterobacteriaceae; ONLY active in the GI tract}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Miscellaneous Nucleic Acid Synthesis Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Metronidazole}} & ↦ Gram (+)  \{\{nl\}\} ↦ Gram (–)  \{\{nl\}\} ↦ Anaerobes  \{\{nl\}\} ↦ Protozoa & ↦ In combo with other agents to cover anaerobes  \{\{nl\}\} ↦ Bacterial vaginosis  \{\{nl\}\} ↦ H. pylori treatment  \{\{nl\}\} ↦ Crohn's disease  \{\{nl\}\} ↦ Giardia infections \tn 
% Row Count 16 (+ 14)
% Row 2
\SetRowColor{LightBackground}
{\bf{Nitrofurantoin}}  \{\{nl\}\} {\bf{Fosfomycin}} & ↦ Gram (+) → Staph  \{\{nl\}\} ↦ Gram (–) → Enterococcus (VRE) + GNR  \{\{nl\}\} ↦ Fosfomycin covers ESBL & ↦ Lower UTIs \tn 
% Row Count 25 (+ 9)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{17.67cm}}{Metronidazole: Gram – and + anaerobes and protozoa \newline Nitrofurantoin: Staphylococcus, Enterococcus (including VRE) and GNRs (not pseudomonas) \newline Fosfomycin: Staphylococcus, Enterococcus (including VRE) and GNRs including many resistant one such as ESBL}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{17.67cm}{x{5.7358 cm} x{5.5671 cm} x{5.5671 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{17.67cm}}{\bf\textcolor{white}{Sulfonamides Family}}  \tn
% Row 0
\SetRowColor{LightBackground}
\{\{ac\}\} {\bf{Antibiotics}} & \{\{ac\}\} {\bf{Bacteria}} & \{\{ac\}\} {\bf{Drug-of-Choice}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Sulfonamides}} \{\{nl\}\}  \seqsplit{(Sulfamethoxazole/trimethoprim)} & ↦  Some \seqsplit{streptococcus} sp.  \{\{nl\}\} ↦  \seqsplit{Staphylococcus} (MRSA)  \{\{nl\}\} ↦  \seqsplit{Enterobacteriaceae}, Listeria, and Nocardia  \{\{nl\}\} ↦  Pneumocystis jiroveci & ↦  DOC for Nocardia and Pneumocystis jiroveci  \{\{nl\}\} ↦  UTIs / SSTIs (MRSA)  \{\{nl\}\} ↦  Treatment \seqsplit{of/prevention} of infection in \seqsplit{immunocompromised} \tn 
% Row Count 14 (+ 12)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}



\end{document}