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% Document Info
\author{CC (cecegnt)}
\pdfinfo{
  /Title (diabete.pdf)
  /Creator (Cheatography)
  /Author (CC (cecegnt))
  /Subject (Diabète Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
    \SetRowColor{DarkBackground}
    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Diabète Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{CC (cecegnt)} via \textcolor{DarkBackground}{\uline{cheatography.com/147750/cs/32145/}}}
\end{tabulary}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}CC (cecegnt) \\
  \uline{cheatography.com/cecegnt} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 19th May, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
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\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Diabète sucré}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{Hyperglycémie chronique \newline % Row Count 1 (+ 1)
1 adulte sur 11 \newline % Row Count 2 (+ 1)
1/3 ne le savent pas \newline % Row Count 3 (+ 1)
Symptômes : polydipsie, polyurie, polyphagie, peau et bouche sèche, asthénie, céphalées, vision altérée% Row Count 6 (+ 3)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Diabète de type I (10\%)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Diagnostic}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}\textless{} 30 ans, 5\% parents touchés} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Étiologie}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Génétique (polygénique) + Environnementale (activation) Ex : jumeau homoZ 40\% si jumeau atteint} \tn 
% Row Count 6 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Description}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Auto-immune, synthèse d'auto-Ac anti cellules β, diagnostic quand 20-30\% fonctionnelles} \tn 
% Row Count 9 (+ 3)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Acido-cétose métabolique}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Complication aigue (25\%) \{\{nl\}\} Foie et muscle : ↑ glucose plasm \{\{nl\}\} TA : ↑ AG/TAG et CC \{\{nl\}\} = acidose avec pH \textless{} 7.3, diurèse osmotique, déshydratation, hypovolémie} \tn 
% Row Count 14 (+ 5)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Traitement}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Injection d'insuline exogène} \tn 
% Row Count 16 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Diagnostic}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Glycémie}} \{\{nl\}\} - À jeun : 4-6 mmol/L ou 0.7-1 g/L \{\{nl\}\} - Non à jeun : \textless{} 6.1 mmol/L ou \textless{} 1.1 g/L} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{HGPO}} Hyperglycémie Provoquée par Voie Orale \{\{nl\}\} 75g de glucose dans 300mL en 5min \{\{nl\}\} T0 : cf glycémie non à jeun \{\{nl\}\} T120 : \textless{} 7.8 mmol/L ou \textless{} 1.4 g/L \{\{nl\}\} Interprétation : \{\{nl\}\} - T0 ↑ : hyperglycémie à jeun \{\{nl\}\} - T120 ↑ : intolérance au glucose \{\{nl\}\} - T0 et T120 ↑ : diabète} \tn 
% Row Count 10 (+ 7)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Glycosurie}} \{\{nl\}\} Pas de glucose dans les urines car réabsorption via co-transporteurs Na/Glc : SGLT2 et SGLT1} \tn 
% Row Count 13 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Diabète de type II (90\%)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Diagnostic}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}\textgreater{} 25 ans, 50\% parents atteints} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Étiologie}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Génétique (polygénique) + Environnementale} \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Description}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Insuline-résistance : \{\{nl\}\} Phase initiale : obésité + hyperinsulinémie (RES) \{\{nl\}\} Phase tardive : ↓ sécrétion insuline} \tn 
% Row Count 8 (+ 4)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Mécanisme}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}TA : Glucose → Malonyl coA via ACC : bloque βox \{\{nl\}\} Insuline favorise stockage TAG \{\{nl\}\} Lipotoxicité → altération signalisation cellulaire du Rc insuline \{\{nl\}\} Métabolisme lipidique OK} \tn 
% Row Count 14 (+ 6)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Syndrome métabolique}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Obésité centrale + intolérance au glucose / T2DM + HTA + dyslipidémie} \tn 
% Row Count 17 (+ 3)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Coma hyperglycémique hyperosmolaire}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Complication aigue \{\{nl\}\} Hyperglycémie → déshydratation mais pas de CC car sécrétion insuline OK} \tn 
% Row Count 21 (+ 4)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Traitement}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Diète équilibrée + activité physique \{\{nl\}\} Φ médicamenteux cf tableau} \tn 
% Row Count 24 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Examen complémentaires}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Fonctionnalité de la cellule β}} \{\{nl\}\} - Insulinémie : ↑ chez T2DM \{\{nl\}\} - Peptide C : estimation sécrétion résiduelles insuline chez T1DM\{\{nl\}\} - Proinsulinémie : rapport PIns/Ins x2-3 chez T2DM} \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Auto-immunité}} \{\{nl\}\} Dosage des auto-Ac : discrimination T2DM / LADA} \tn 
% Row Count 7 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Sensibilité à l'insuline}} \{\{nl\}\} Oui pour T1DM, Non pour T2DM} \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Marqueurs de suivi}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Hémoglbine glyquée HbA1c}} \{\{nl\}\} Surveillance de l'équilibre glycémique\{\{nl\}\} Rétrospectif des 3 derniers mois \{\{nl\}\} Pourcentage normal : 4-6\%} \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Microalbuminerie}} Absente des urines} \tn 
% Row Count 5 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Corps cétoniques}} Surveillance T1DM et D gravidique} \tn 
% Row Count 7 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{DKA / HHS}} \{\{nl\}\} DKA : pH acide, ↓ HCO3-, ↑ trou anionique \{\{nl\}\} HHS : glycémie +++ \{\{nl\}\}} \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Autres types de diabète}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{LADA (Type 1.5)}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Diabète latent : auto-immun mais dev chez l'adulte \{\{nl\}\} Dysfonctionnement cellules β + insulinorésistance \{\{nl\}\} IMC normal ou surpoids} \tn 
% Row Count 4 (+ 4)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{MODY (monogénique)}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Insuline OK, profil lip OK \{\{nl\}\} Mutation : HNFA1 ou GlucoK} \tn 
% Row Count 7 (+ 3)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Néonatal (NDM, monogénique)}}} \tn 
\mymulticolumn{1}{x{5.377cm}}{\hspace*{6 px}\rule{2px}{6px}\hspace*{6 px}Transitoire ou permanent, défaut sécrétion insuline \{\{nl\}\} Mutation : activation des canaux K ATP dep} \tn 
% Row Count 11 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Advanced Glycation End products (AGEs)}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{Hyperglycémie prolongée → glycation des pz → AGEs \{\{nl\}\} Accumulation dans le glycogène + stimulation pro-inflammatoire \{\{nl\}\} Macrophages et c. endoT possèdent des Rc RAGE \{\{nl\}\} → ↑ processus pro-infl + vasoconstriction \{\{nl\}\}\{\{nl\}\} {\bf{Complications :}} \{\{nl\}\} Microvasculaire : rétinoP, néphroP, neuroP \{\{nl\}\} Macrovasculaire : athérosclérose, maladies CV, pied diabétique} \tn 
% Row Count 8 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{5.377cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Complications orales}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Maladie parodontale}}\{\{nl\}\}6ème la + fréquente, 60 \% des diabétiques, \{\{nl\}\}Prévalence 2-4 x \textgreater{} sujets sains \{\{nl\}\} Relation bidirectionnelle gravité diabète / m. paro \{\{nl\}\} Gingivite → Parodontite → Perte dentaire \{\{nl\}\} \{\{nl\}\} Impact du diabète : \{\{nl\}\} - Formation plaque : Glc augmente croissance β \{\{nl\}\} - Destruction parodonte via PMNs \{\{nl\}\} - Réaction inflam : cytokines +++ \{\{nl\}\} - Perte osseuse : AGEs cx avec collagène + recrutement ostéoclastes \{\{nl\}\}} \tn 
% Row Count 10 (+ 10)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Dysfonctionnement salivaire et gustatif}} \{\{nl\}\} Xérostomie (40-80\%) + Sialose + Halitose (75\%)} \tn 
% Row Count 12 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{5.377cm}}{{\bf{Infections et lésions}} \{\{nl\}\} Infections β + candidoses, lichen plan, retard de cicatrisation} \tn 
% Row Count 14 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}