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% Most of the following are not required for the majority
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% Document Info
\author{Carm (Carmilaa)}
\pdfinfo{
  /Title (antiretroviral-therapy.pdf)
  /Creator (Cheatography)
  /Author (Carm (Carmilaa))
  /Subject (Antiretroviral Therapy: Cheat Sheet)
}

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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\columnbreak
\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Antiretroviral Therapy: Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Carm (Carmilaa)} via \textcolor{DarkBackground}{\uline{cheatography.com/49544/cs/16182/}}}
\end{tabulary}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Carm (Carmilaa) \\
  \uline{cheatography.com/carmilaa} \\
  \end{tabulary}
\vfill
\columnbreak
\begin{tabulary}{5.8cm}{L}
  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Published 26th June, 2018.\\
   Updated 26th June, 2018.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
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  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\begin{document}
\raggedright
\raggedcolumns

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% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
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\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{CDC Stage of HIV Disease}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{-{\bf{Stage I:}} Acute HIV infection \newline % Row Count 1 (+ 1)
-{\bf{Stage II:}} Asymptomatic HIV \newline % Row Count 2 (+ 1)
-{\bf{Stage III:}} Early Symptomatic HIV \newline % Row Count 3 (+ 1)
-{\bf{Stage IV:}} Late Symptomatic HIV \newline % Row Count 4 (+ 1)
= A				Constitutional Disease \newline % Row Count 5 (+ 1)
= B				Neurological Disease \newline % Row Count 6 (+ 1)
= C				Secondary Infections \newline % Row Count 7 (+ 1)
     -C1					AIDS defining \newline % Row Count 8 (+ 1)
     -C2					Other infections \newline % Row Count 9 (+ 1)
= D				Secondary Cancers \newline % Row Count 10 (+ 1)
= E				Other Conditions% Row Count 11 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{0.836 cm} x{3.42 cm} x{3.344 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Clinical Staging of Oral Manifestations of HIV}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Stage:}} & {\bf{Adults and Adolescents (\textgreater{}15yo)}} & {\bf{Children (\textless{}15yo):}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
1 & No disease & No disease \tn 
% Row Count 4 (+ 1)
% Row 2
\SetRowColor{LightBackground}
2 & Angular Chellitis, Recurrent oral ulcerations & Angular Chellitis, Linear gingival erythema, extensive warts, Recurrent oral ulcerations, Parotid enlarge \tn 
% Row Count 11 (+ 7)
% Row 3
\SetRowColor{white}
3 & Persistent oral candidiasis, Oral hairy leukoplakia, Acute necrotizing ulcerative stomatitis, gingivitis, periodontitis & Persistent oral candidiasis (after 8wks), Oral hairy leukoplakia, Acute necrotizing ulcerative gingivitis or periodontitis. \tn 
% Row Count 19 (+ 8)
% Row 4
\SetRowColor{LightBackground}
4 & Chronic (\textgreater{}1mo) orolabial HSV, Kaposi's sarcoma, & Chronic (\textgreater{}1mo) orolabial HSV, Karpo's Sarcoma, Non-Hodgkin's lymphoma \tn 
% Row Count 24 (+ 5)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.16 cm} x{5.84 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{{\bf{HIV-related Oral Lesions:}}}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Infections:}} & - Fungal, Viral, Bacteria \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
{\bf{Neoplams:}} & - Kaposi's Sarcoma, Non-Hodgkin's Lymphoma \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
{\bf{Other:}} & - Aphthous-like Ulcers, Lichenoid or drug reactions, Salivary Gland Disease \tn 
% Row Count 7 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{{\bf{Oral Candidiasis:}}}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Erythematous Chelitis} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Pseudomembranous} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Angular} \tn 
% Row Count 3 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.12 cm} x{4.88 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{{\bf{Oral Ulcers:}}}}  \tn
% Row 0
\SetRowColor{LightBackground}
-Herpes Simplex Infection & -HPV Lesiosn \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\seqsplit{-Cytomegalovirus} Infection & -Lymphoma \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
-Aphthous Ulcers & -Necrotizing ulcerative gingivitis/ periodontitis \tn 
% Row Count 7 (+ 3)
% Row 3
\SetRowColor{white}
\seqsplit{-Histoplasmosis} & -Necrotizing Stomamtitis (NS) \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{There are many different causes of oral ulceration in patients with HIV infection = Herpes simplex infection, Varicella zoster infection. Accurate diagnosis and appropriate management of oral ulceration in patients with HIV infection generally result in complete healing of the ulceration.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.672 cm} x{2.964 cm} x{2.964 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Aphthous Lesions Clinical Types}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Topical Therapy:}} & {\bf{Intralesional:}} & {\bf{Systemic Therapy:}} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
Topical \seqsplit{Corticosteroids} & Triamcinolone: 40 mg /ml (0.5 ml-1.0 ml injected bid) & Prednisone: 0.5-1.0 mg/kg qd x 7-10d, then taper \tn 
% Row Count 7 (+ 4)
% Row 2
\SetRowColor{LightBackground}
 &  & Thalidomide: 200 mg PO qd \tn 
% Row Count 9 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{1.76 cm} x{6.24 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Antiretroviral Cancer:}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{NRTIs:}} & Nucleoside OR Nucleotide Reverse Transcriptase Inhibitors (Nukes) \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
{\bf{NNRTIs:}} & Non-nucleoside Reverse Transcriptase Inhibitors (non-nukes) \tn 
% Row Count 5 (+ 2)
% Row 2
\SetRowColor{LightBackground}
{\bf{PIs:}} & Protase Inhibitors \tn 
% Row Count 6 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Fusion Inhibitors}}} \tn 
% Row Count 7 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Chemokine Receptor Antagonists}}} \tn 
% Row Count 8 (+ 1)
% Row 5
\SetRowColor{white}
\mymulticolumn{2}{x{8.4cm}}{{\bf{Integrase Inhibitors}}} \tn 
% Row Count 9 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{See Life cycle of HIV}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Current Antiretroviral Targets}}  \tn
\SetRowColor{LightBackground}
\mymulticolumn{1}{p{8.4cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/carmilaa_1530025246_Capture.PNG}}} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{4 cm} x{4 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{Reverse Transcriptase Inhibitors:}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Nucleoside Analogues}} Zidovudine (AZT, ZDV) Didanosine (ddI) Zalcitabine (ddC) Stavudine (d4T) Lamivudine (3TC) Abacavir (ABC) Emtricitabine (FTC) & {\bf{Non-nucleoside analogues:}}  Nevirapine (NVP)  delavirdine (DLV)                Efavirenz (EFV)  etravirine (ETV)  rilpivirine (RPV) \tn 
% Row Count 8 (+ 8)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{{\bf{ Nucleotide analogue}} \newline Tenofovir (TFV)}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Protease Inhibitors:}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{saquinavir (SQV) \newline % Row Count 1 (+ 1)
ritonavir (RTV) \newline % Row Count 2 (+ 1)
indinavir (IDV) \newline % Row Count 3 (+ 1)
nelfinavir (NFV) \newline % Row Count 4 (+ 1)
amprenavir (APV) \newline % Row Count 5 (+ 1)
lopinavir (LPV) \newline % Row Count 6 (+ 1)
fosamprenavir (FPV) \newline % Row Count 7 (+ 1)
atazanavir (ATV) \newline % Row Count 8 (+ 1)
tipranavir (TPV) \newline % Row Count 9 (+ 1)
darunavir (DRV) \newline % Row Count 10 (+ 1)
{\bf{dolutegravir (DTG)}}% Row Count 11 (+ 1)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{2.736 cm} x{2.432 cm} x{2.432 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{3}{x{8.4cm}}{\bf\textcolor{white}{Reverse Transcriptase Inhibitors:}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Integrase Inhibitors}} & {\bf{Fusion Inhibitor:}} & {\bf{Entry Inhibitors:}} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
raltegravir (RAL) & fuzeon (T20) & maraviroc (MVC) \tn 
% Row Count 4 (+ 2)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{3}{x{8.4cm}}{elvitegravir (ELV)} \tn 
% Row Count 5 (+ 1)
\hhline{>{\arrayrulecolor{DarkBackground}}---}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{x{3.68 cm} x{4.32 cm} }
\SetRowColor{DarkBackground}
\mymulticolumn{2}{x{8.4cm}}{\bf\textcolor{white}{NRTIs Mechanism of Action:}}  \tn
% Row 0
\SetRowColor{LightBackground}
{\bf{Nucleoside Analogs (like AZT):}} & Analog of thymidine, cytosine or guanine \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
 & Triphosphorylated inside lymphocytes to active compound. \tn 
% Row Count 5 (+ 3)
% Row 2
\SetRowColor{LightBackground}
 & Incorporate into growing HIV viral DNA strand by reverse transcriptase. \tn 
% Row Count 9 (+ 4)
% Row 3
\SetRowColor{white}
{\bf{Nucleotide Analogs:}} & tenofovir (TDF) \tn 
% Row Count 11 (+ 2)
% Row 4
\SetRowColor{LightBackground}
 & does NOT need to be tri-phosphorylated only di-phosphorylated to activate compound. \tn 
% Row Count 15 (+ 4)
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\SetRowColor{LightBackground}
\mymulticolumn{2}{x{8.4cm}}{After incorporation of NRTIs, viral DNA synthesis will be terminated.}  \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}--}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Non-nucleoside Reverse Transcriptase Inhibitors:}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Agents directly bind to reverse transcriptase to inhibit transcription.} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{NNRTIs do not require phosphorylation to be active.} \tn 
% Row Count 4 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Protease Inhibitors (PIs) MOA:}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Protease enzyme cleaves HIV precursor proteins into active proteins that are needed to assemble a new, mature HIV virus.} \tn 
% Row Count 3 (+ 3)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{PIs bind to protease preventing the cleavage and inhibiting the assembly of new HIV viruses.} \tn 
% Row Count 5 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Fusion Inhibitor:}}  \tn
\SetRowColor{LightBackground}
\mymulticolumn{1}{p{8.4cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/carmilaa_1530035564_Capture.PNG}}} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Chemokine Receptor Antagonists:}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Marviroc (Selzentry)} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{CCR5 or CXCR4 receptors on cell surface} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Virus will bind to one of the 2 receptors (some pt virus will bind to either receptors)} \tn 
% Row Count 4 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Marviroc blocks viral entry at CCR5} \tn 
% Row Count 5 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Dosed 300mg BID= 150mg BID with P450 inhibitors. = 600mg BID with P450 inducers} \tn 
% Row Count 7 (+ 2)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Integrase Inhibitors}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Raltegravir (Isentress)} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Dosed = 400mg BID (1tab BID)} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{No induction or inhibition on CYP450 enzymes or Pgp} \tn 
% Row Count 4 (+ 2)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Metabolized by UGT1A1 (glucuronidation) = Only affected by drugs that inhibit or induce UGTs (ie. rifampin)} \tn 
% Row Count 7 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}