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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
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% Most of the following are not required for the majority
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% Document Info
\author{Ashley.yong}
\pdfinfo{
  /Title (medicinal-chemistry.pdf)
  /Creator (Cheatography)
  /Author (Ashley.yong)
  /Subject (Medicinal chemistry Cheat Sheet)
}

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% Header and Footer
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\fancyhead[L]{
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Medicinal chemistry Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{Ashley.yong} via \textcolor{DarkBackground}{\uline{cheatography.com/149395/cs/32464/}}}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
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  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}Ashley.yong \\
  \uline{cheatography.com/ashley-yong} \\
  \end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 13th June, 2022.\\
   Page {\thepage} of \pageref{LastPage}.
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  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
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% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{3}

\begin{tabularx}{5.377cm}{X}
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{Medicinal chemistry}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{Definition:} \tn 
% Row Count 1 (+ 1)
% Row 1
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Drugs:}} A medicine or other substances which has a marked effect when taken into body.} \tn 
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% Row 2
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Medicine:}} A drug or other preparation is taken into body in order to treat or prevent disease} \tn 
% Row Count 5 (+ 2)
% Row 3
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Drug Name:}} Adopted by company during development} \tn 
% Row Count 7 (+ 2)
% Row 4
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Proprietary Name:}} Registered \& used by company exclusively} \tn 
% Row Count 9 (+ 2)
% Row 5
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Systemic Name:}} By IUPAC rules} \tn 
% Row Count 10 (+ 1)
% Row 6
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Research Code:}} Letter \& no. For company to identify the particular compound} \tn 
% Row Count 12 (+ 2)
% Row 7
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Generic Name:}} Recommended international non proprietary name by WHO when patent has expired} \tn 
% Row Count 14 (+ 2)
% Row 8
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\mymulticolumn{1}{x{5.377cm}}{Classifications of drug} \tn 
% Row Count 15 (+ 1)
% Row 9
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Chemical Structure:}}  \{\{nl\}\} Common skeleton structure  \{\{nl\}\} May have same biological activity} \tn 
% Row Count 17 (+ 2)
% Row 10
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Pharmacological effect:}} \{\{nl\}\} Same biological outcome, different pathway  \{\{nl\}\} Limit drug use eg. :anti-fungal} \tn 
% Row Count 20 (+ 3)
% Row 11
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Target System:}} \{\{nl\}\} Same biological outcome different pathway(Specific chemical messengers) \{\{nl\}\}Synthesis,mimics,blocks,degradation} \tn 
% Row Count 23 (+ 3)
% Row 12
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Target Molecule:}} \{\{nl\}\} Affects specific enzyme, neurotransmitter or receptors \{\{nl\}\}Same biological outcome, same pathways \{\{nl\}\}Similar structure} \tn 
% Row Count 27 (+ 4)
% Row 13
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\mymulticolumn{1}{x{5.377cm}}{Membrane Permeability coefficient :} \tn 
% Row Count 28 (+ 1)
% Row 14
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\mymulticolumn{1}{x{5.377cm}}{1. Depend on lipophilicity \& molecular charge \{\{nl\}\}2. Large coefficient = Good permeability ; Small coefficient = Poor permeability- highly charged (+/-) \{\{nl\}\}3. \textasciitilde{}80\% drug posses a charge, depend on pH of the medium \& pKa of a FG} \tn 
% Row Count 33 (+ 5)
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{pKa}}  \tn
% Row 0
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Bronsted-Lowry Theory}}} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{5.377cm}}{HA + B  ⇌ A\textasciicircum{}-\textasciicircum{} + HB\textasciicircum{}+\textasciicircum{} \{\{nl\}\} Acid + Base ⇌ Conjugated Base + Conjugated acid} \tn 
% Row Count 3 (+ 2)
% Row 2
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\mymulticolumn{1}{x{5.377cm}}{{\bf{Henderson-Hasselbalch}}} \tn 
% Row Count 4 (+ 1)
% Row 3
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\mymulticolumn{1}{x{5.377cm}}{pKa = pH- Log( {[}Conjugated base{]}/{[}Weak acid{]}) \{\{nl\}\} {\bf{pKa:}} pH at which 50\% of substance is ionized} \tn 
% Row Count 7 (+ 3)
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\mymulticolumn{1}{x{5.377cm}}{\bf\textcolor{white}{pKa (copy)}}  \tn
% Row 0
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% Row 1
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\mymulticolumn{1}{x{5.377cm}}{HA + B  ⇌ A\textasciicircum{}-\textasciicircum{} + HB\textasciicircum{}+\textasciicircum{} \{\{nl\}\} Acid + Base ⇌ Conjugated Base + Conjugated acid} \tn 
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\mymulticolumn{1}{x{5.377cm}}{pKa = pH- Log( {[}Conjugated base{]}/{[}Weak acid{]}) \{\{nl\}\} {\bf{pKa:}} pH at which 50\% of substance is ionized} \tn 
% Row Count 7 (+ 3)
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\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}