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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
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% Document Info
\author{ACD Marketing Team (ACD Marketing)}
\pdfinfo{
  /Title (prostate-cancer-cheat-sheet.pdf)
  /Creator (Cheatography)
  /Author (ACD Marketing Team (ACD Marketing))
  /Subject (Prostate Cancer Cheat Sheet)
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% Header and Footer
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Prostate Cancer Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{ACD Marketing Team (ACD Marketing)} via \textcolor{DarkBackground}{\uline{cheatography.com/36805/cs/11872/}}}
\end{tabulary}
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}ACD Marketing Team (ACD Marketing) \\
  \uline{cheatography.com/acd-marketing} \\
        \uline{\seqsplit{www}.acdbio.com}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 23rd May, 2017.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
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  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
  \SetRowColor{white}
  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
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\end{multicols}}




\begin{document}
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% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{One Minute Pitch}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{The study of the tumor microenvironment expands the understanding of the role of the tumor microenvironment in cancer initiation, progression and metastases. Examination of the TME offers a more comprehensive understanding of the composition of the stroma in normal tissues, with the goal of delineating the mechanisms of tumor-stromal interactions in cancer.% Row Count 8 (+ 8)
} \tn 
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Prostate Cancer Related Probes}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{\seqsplit{ACACA	AKT1	APC	AR	ARNTL	BCL2	CAMKK1	CAMSAP1	CASP3	CAV1	CAV2	CCNA1	CCND1	CCND2	CDH1	CDKN2A	CLN3	CREB1	DAXX	DKK3	DLC1	ECT2	EDNRB	EGFR	EGR3	ERG	ETV1	FASN	FOXO1	GNRH1	GPX3	GSTP1	HAL	HMGCR	IGF1	IGFBP5	IL6	KLHL13	KLK3	LGALS4	LOXL1	MAPK1	MAX	MGMT	MKI67	MSX1}      \seqsplit{MTO1	NDRG3	NFKB1	NKX3-1	NRIP1	PDLIM4	PDPK1	PES1	PPP2R1B	PRKAB1	PTEN	PTGS1	PTGS2	RARB	RASSF1	RBM39	SCAF11	SEPT7	SFRP1	SLC5A8	SOCS3	SOX4	SREBF1	STK11	SUPT7L	TFPI2	TIMP2	TIMP3	TMPRSS2	TNFRSF10D	TP53	VEGFA	ZNF185}% Row Count 10 (+ 10)
} \tn 
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\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Applications}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Reactivation of WNT by SOX9 drives PCa:}} SOX9 has been implicated in PCa but the SOX9-dependent genes and pathways involved are not well known. Ma et al. used SOX9 ChIP-Seq and transcriptome profiling to identify the spectrum of SOX9-related genes and pathways in PCa. RNAscope® ISH validated the microarray results in human PCa samples and showed that SOX9 levels correlated with WNT pathway components. http://bit.ly/2q9JrDB} \tn 
% Row Count 9 (+ 9)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Correlation of the lncRNA SChLAP1 with PCa disease progression:}}  Mehra et al. used RNAscope® ISH to demonstrate that PCa patients with high expression of the lncRNA SChLAP1 had a significantly higher chance of developing lethal disease, suggesting SChLAP1 could be a tissue-based prostate cancer biomarker. http://bit.ly/2qHzfFn} \tn 
% Row Count 16 (+ 7)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Identification of the cellular localization of the secreted factor IL6 in PCa:}} IL6 is known to contribute to the development and/or progression of PCa. Yu et al. used RNAscope® ISH to reveal that IL6 expression was nearly exclusively restricted to the prostate stromal compartment. http://bit.ly/2qOGp93} \tn 
% Row Count 23 (+ 7)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Marketing Materials}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Recorded Webinar:}} "Elucidating tumor heterogeneity in prostate cancer by combined IHC \& novel RNA ISH"  presented by Nallasivam Palanisamy, PhD, Associate Scientist Department of Urology Henry Ford Health System, Detroit, MI.} \tn 
% Row Count 5 (+ 5)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Spotlight Interview:}} Interview with Dr Rohit Mehra: "Realising the potential of Ion noncoding RNA as a cancer biomarker - From NGS discovery to validation with RNA In Situ Hybridization"} \tn 
% Row Count 9 (+ 4)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Spotlight Interview:}} Interview with Dr Nallasivam Palanisamy: "Development of Prostate Cancer Personalized Medicine - Advancing analysis of prostate tumor molecular heterogeneity by combined immunohistochemistry and novel RNA in situ hybridization"} \tn 
% Row Count 15 (+ 6)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Related publications:}} http://bit.ly/2rtjsem} \tn 
% Row Count 16 (+ 1)
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Special Case: AR-V7 - CRPC}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Despite removal of the prostate and a reduction in androgen levels, some cases of prostate cancer still rely on androgen signaling \newline % Row Count 3 (+ 3)
-{}-\textgreater{} Known as castration-resistant prostate cancer (CRPC) \newline % Row Count 5 (+ 2)
Many drug therapies for CRPC focus on attenuating androgen pathway \newline % Row Count 7 (+ 2)
-{}-\textgreater{} Enzalutamide and Abiraterone \newline % Row Count 8 (+ 1)
20-40\% of CRPC patients have no response to these drugs \newline % Row Count 10 (+ 2)
-{}-\textgreater{} Referred to as drug-resistant CRPC or androgen-independent CRPC \newline % Row Count 12 (+ 2)
Correlation between drug-resistant CRPC patients and AR-V7 status% Row Count 14 (+ 2)
} \tn 
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{BaseScope and RNAscope probes for AR detection}}  \tn
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\mymulticolumn{1}{p{8.4cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/acd-marketing_1495532487_AR-V7 Probes.png}}} \tn 
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{AR-V7 Detection Methods}}  \tn
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\mymulticolumn{1}{p{8.4cm}}{\vspace{1px}\centerline{\includegraphics[width=5.1cm]{/web/www.cheatography.com/public/uploads/acd-marketing_1495542700_AR-V7.png}}} \tn 
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\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}