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%\usepackage{opensans}          % Can't make this work so far. Shame. Would be lovely.
\usepackage[normalem]{ulem}     % For underlining links
% Most of the following are not required for the majority
% of cheat sheets but are needed for some symbol support.
\usepackage{amsmath}            % Symbols
\usepackage{MnSymbol}           % Symbols
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% Document Info
\author{ACD Marketing Team (ACD Marketing)}
\pdfinfo{
  /Title (lung-cancer-cheat-sheet.pdf)
  /Creator (Cheatography)
  /Author (ACD Marketing Team (ACD Marketing))
  /Subject (Lung Cancer Cheat Sheet)
}

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% Commands
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% Header and Footer
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\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{C}
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    \vspace{-7pt}
    {\parbox{\dimexpr\textwidth-2\fboxsep\relax}{\noindent
        \hspace*{-6pt}\includegraphics[width=5.8cm]{/web/www.cheatography.com/public/images/cheatography_logo.pdf}}
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\begin{tabulary}{11cm}{L}
    \vspace{-2pt}\large{\bf{\textcolor{DarkBackground}{\textrm{Lung Cancer Cheat Sheet}}}} \\
    \normalsize{by \textcolor{DarkBackground}{ACD Marketing Team (ACD Marketing)} via \textcolor{DarkBackground}{\uline{cheatography.com/36805/cs/11873/}}}
\end{tabulary}
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\fancyfoot[L]{ \footnotesize
\noindent
\begin{multicols}{3}
\begin{tabulary}{5.8cm}{LL}
  \SetRowColor{FootBackground}
  \mymulticolumn{2}{p{5.377cm}}{\bf\textcolor{white}{Cheatographer}}  \\
  \vspace{-2pt}ACD Marketing Team (ACD Marketing) \\
  \uline{cheatography.com/acd-marketing} \\
        \uline{\seqsplit{www}.acdbio.com}
  \end{tabulary}
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  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Cheat Sheet}}  \\
   \vspace{-2pt}Not Yet Published.\\
   Updated 23rd May, 2017.\\
   Page {\thepage} of \pageref{LastPage}.
\end{tabulary}
\vfill
\columnbreak
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  \SetRowColor{FootBackground}
  \mymulticolumn{1}{p{5.377cm}}{\bf\textcolor{white}{Sponsor}}  \\
  \SetRowColor{white}
  \vspace{-5pt}
  %\includegraphics[width=48px,height=48px]{dave.jpeg}
  Measure your website readability!\\
  www.readability-score.com
\end{tabulary}
\end{multicols}}




\begin{document}
\raggedright
\raggedcolumns

% Set font size to small. Switch to any value
% from this page to resize cheat sheet text:
% www.emerson.emory.edu/services/latex/latex_169.html
\footnotesize % Small font.

\begin{multicols*}{2}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{One Minute Pitch}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{Lung tumors are highly heterogeneous, with great variability between individual patients, cancer types, and stages, as well as intra-tumor heterogeneity. This variability poses a considerable challenge in identifying and validating clinically relevant lung cancer biomarkers. Therefore, spatially-mapped gene expression at the cellular level is crucial to understand the cell-to-cell interactions in the tumor and the cellular makeup within the complex tumor microenvironment (TME).% Row Count 10 (+ 10)
} \tn 
\hhline{>{\arrayrulecolor{DarkBackground}}-}
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\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
\SetRowColor{DarkBackground}
\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Key Selling Point}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Assessment of predictive markers for lung cancer} \tn 
% Row Count 1 (+ 1)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{When antibodies are not available e.g. ARNTL2} \tn 
% Row Count 2 (+ 1)
% Row 2
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Characterization of secreted proteins} \tn 
% Row Count 3 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Validation of transcriptome data} \tn 
% Row Count 4 (+ 1)
% Row 4
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Detection of lncRNAs in lung cancer - e.g. LINC00473 could be used as a surrogate biomarker for LKB1 in lung cancer samples.} \tn 
% Row Count 7 (+ 3)
% Row 5
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{Detection of lncRNAs in lung cancer - ACD60 NSCLC lncRNA study} \tn 
% Row Count 9 (+ 2)
% Row 6
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{Detection of immune cell checkpoint and functional lung cancer biomarkers in the TME - ACD 60 NSCLC immuno-oncology study} \tn 
% Row Count 12 (+ 3)
\hhline{>{\arrayrulecolor{DarkBackground}}-}
\end{tabularx}
\par\addvspace{1.3em}

\begin{tabularx}{8.4cm}{X}
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Marketing Materials}}  \tn
% Row 0
\SetRowColor{LightBackground}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Lung Cancer related publications:}} http://bit.ly/2rtGXny} \tn 
% Row Count 2 (+ 2)
% Row 1
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Scientific Poster:}}} \tn 
% Row Count 3 (+ 1)
% Row 2
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\mymulticolumn{1}{x{8.4cm}}{{\bf{lncRNA in lung Cancer:}} Coming soon} \tn 
% Row Count 4 (+ 1)
% Row 3
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{{\bf{Application note:}} "Detection of immune cell checkpoint and functional markers in the tumor microenvironment by the RNA in situ hybridization RNAscope® assay'} \tn 
% Row Count 8 (+ 4)
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\par\addvspace{1.3em}

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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Lung Cancer Related Probes}}  \tn
\SetRowColor{white}
\mymulticolumn{1}{x{8.4cm}}{\seqsplit{AGER	AGR2	AKT1	ANXA5	APBA1	APC	BCL2	BIRC5	BRAF	CA4	CADM1	CDH1	CDH13	CDKN1C	CDKN2A	CDKN2B	CEACAM5	CEACAM6	CLCA2	CLDN18	CLIC5	COL11A1	CP	CSF3	CXCL12	CXCL13	CYP1B1	DLC1	DSG3	DUSP6	EGFR	ERBB2	ERBB3	FABP4	FHIT	GPM6A	GREM1	HGF	HMMR	HRAS	IRF4	KRAS	KRT14	KRT5	LCK	LGSN	MET	MGMT	MKI67	MLH1	MMD	MMP1	MMP12	MMP9	MTHFR	NF1	NFKB1	NKX2-1	OPCML	PAX5	PRDM2	PTGS2	RASSF1	RASSF2	RB1	SCGB1A1	SFRP1	SFTA3	SFTPC	SOSTDC1	SPINK1	SPP1	SPRR1A	STAT1	STAT2	TCF21	TERT	TGFB1	TNF	TOP2A	TOX3	TP53	VEGFA	WIF1}% Row Count 10 (+ 10)
} \tn 
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{Special Case: MET-delta 14 in lung cancer}}  \tn
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\mymulticolumn{1}{x{8.4cm}}{Nearly all of the MET exon 14 mutations described to date cause skipping of MET exon 14 during pre-mRNA splicing. \newline % Row Count 3 (+ 3)
Skipping of exon 14 in the MET gene results in impaired c-Met receptor degradation, constitutive activation of the MET receptor, and oncogenic transformation of MET.  \newline % Row Count 7 (+ 4)
This variant, referred to as METΔ14, is a gain-of-function phenotype that can respond positively to some therapeutics and is present in a variety of cancer types, particularly lung cancer, where it is present in approximately 3\% of non-small cell lung carcinoma cases.  \newline % Row Count 13 (+ 6)
Detection of alterations in MET exon 14 could aid in identifying patients likely to benefit from MET inhibitors. The BaseScope assay for exon junction detection is the solution here.% Row Count 17 (+ 4)
} \tn 
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\mymulticolumn{1}{x{8.4cm}}{\bf\textcolor{white}{MET-Delta 14 probe design}}  \tn
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\par\addvspace{1.3em}


% That's all folks
\end{multicols*}

\end{document}